{ "uniprot_canonical_ac": "A2AIR5-1", "sequence": { "header": "tr|A2AIR5-1|A2AIR5_MOUSE Isoform 1 of Glutamate receptor ionotropic, NMDA3A OS=Mus musculus OX=10090 GN=Grin3a PE=1 SV=1 CANONICAL=A2AIR5-1", "length": 1135, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES" }, "uniprot_id": "A2AIR5_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "glutamate receptor ionotropic, NMDA 3A isoform 1 precursor" ], "uniprotkb": [ "Glutamate receptor ionotropic, NMDA3A" ] }, "gene": { "refseq": [ "Grin3a", "6430537F04", "A830097C19Rik", "mKIAA1973", "NMDAR-L", "NR3A" ], "uniprotkb": [ "Grin3a", "6430537F04", "A830097C19Rik", "mKIAA1973", "NMDAR-L", "NR3A" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Glutamate receptor ionotropic, NMDA3A." }, "publication": [ { "title": "Single-cell transcriptomic analysis of mouse neocortical development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30635555", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ", "date": "2019", "pmid": "30635555" }, { "title": "Unmasking GluN1/GluN3A excitatory glycine NMDA receptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30425244", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Grand T, Abi Gerges S, David M, Diana MA, Paoletti P", "date": "2018", "pmid": "30425244" }, { "title": "The siRNA-mediated knockdown of GluN3A in 46C-derived neural stem cells affects mRNA expression levels of neural genes, including known iGluR interactors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29438442", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Pachernegg S, Eilebrecht S, Eilebrecht E, Schoneborn H, Neumann S, Benecke AG, Hollmann M", "date": "2018", "pmid": "29438442" }, { "title": "Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29554474", "journal": "Experimental neurology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Lee JH, Zhang JY, Wei ZZ, Yu SP", "date": "2018", "pmid": "29554474" }, { "title": "GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27072890", "journal": "Neurobiology of disease", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Mahfooz K, Marco S, Martinez-Turrillas R, Raja MK, Perez-Otano I, Wesseling JF", "date": "2016", "pmid": "27072890" }, { "title": "Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14983056", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Kattenstroth G, Tantalaki E, Sudhof TC, Gottmann K, Missler M", "date": "2004", "pmid": "14983056" }, { "title": "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11735224", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Andersson O, Stenqvist A, Attersand A, von Euler G", "date": "2001", "pmid": "11735224" }, { "title": "Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9620802", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N", "date": "1998", "pmid": "9620802" }, { "title": "Hypomyelinated mutant mice IV: peripheral myelin in jp msd.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/7306792", "journal": "Brain research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Billings-Gagliardi S, Adcock LH", "date": "1981", "pmid": "7306792" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2354", "id": "2354", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "relation": "attached", "position": 426, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5#A2AIR4-1", "isoform_ac": "A2AIR4-1", "locus": { "end_pos": 49665229, "start_pos": 49845081, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000076674", "id": "ENSMUST00000076674", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000075970", "id": "ENSMUSP00000075970", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AIR4-1|A2AIR5_MOUSE Computationally mapped isoform of Glutamate receptor ionotropic, NMDA3A OS=Mus musculus OX=10090 GN=Grin3a PE=1 SV=1 CANONICAL=A2AIR5-1", "length": 1115, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES" } }, { "url": "https://www.uniprot.org/uniprot/A2AIR5#A2AIR5-1", "isoform_ac": "A2AIR5-1", "locus": { "end_pos": 49665229, "start_pos": 49845081, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000093859", "id": "ENSMUST00000093859", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091381", "id": "ENSMUSP00000091381", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AIR5-1|A2AIR5_MOUSE Isoform 1 of Glutamate receptor ionotropic, NMDA3A OS=Mus musculus OX=10090 GN=Grin3a PE=1 SV=1 CANONICAL=A2AIR5-1", "length": 1135, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9609736", "resource": "Reactome", "id": "R-MMU-9609736", "name": "Assembly and cell surface presentation of NMDA receptors" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "In the prefrontal cortex of GluN3A knock-out mice, the expression of the oxytocin receptor was significantly lower.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "This study for the first time provides insights into transcriptome changes upon the specific knockdown of an NMDAR subunit in NSCs, which may help to identify additional functions and downstream pathways of GluN3A and GluN3A-containing NMDARs Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "Results implicate GluN3A reactivation in a broad spectrum of early-stage synaptic transmission deficits in YAC128 mice", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "Decrease in NMDA-receptor activity in alpha-neurexin-deficient synapses", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9R1M7-1", "protein_name": "Glutamate receptor ionotropic, NMDA 3A; GluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-L1; N-methyl-D-aspartate receptor; NMDAR-L; Glutamate receptor chi-1.", "sequence": { "length": 1135, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128613", "id": "128613", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8TCU5-1", "protein_name": "Glutamate receptor ionotropic, NMDA 3A; GluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-L.", "sequence": { "length": 1115, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128613", "id": "128613", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "ac": "NP_001263284.1", "name": "glutamate receptor ionotropic, NMDA 3A isoform 1 precursor.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "calcium channel activity", "id": "GO:0005262" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential", "id": "GO:1904315" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008066", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "glutamate receptor activity", "id": "GO:0008066" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004972", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "NMDA glutamate receptor activity", "id": "GO:0004972" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051721", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "protein phosphatase 2A binding", "id": "GO:0051721" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004970", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "ionotropic glutamate receptor activity", "id": "GO:0004970" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016594", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "glycine binding", "id": "GO:0016594" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "neurotransmitter binding", "id": "GO:0042165" } ], "total": 9, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "glutamatergic synapse", "id": "GO:0098978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": 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