{ "uniprot_canonical_ac": "A2AHL1-1", "sequence": { "header": "sp|A2AHL1-1|ANO3_MOUSE Isoform 1 of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 981, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP" }, "uniprot_id": "ANO3_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "anoctamin-3 isoform 1", "ano3" ], "uniprotkb": [ "Anoctamin-3", "Transmembrane protein 16C" ] }, "gene": { "refseq": [ "Ano3", "AI838058", "B230324K02Rik", "Tmem16c" ], "uniprotkb": [ "Ano3", "Tmem16c", "AI838058", "B230324K02Rik" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Anoctamin-3; Transmembrane protein 16C." }, "publication": [ { "title": "TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23872594", "journal": "Nat. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1/publications", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Wang X., Huang F., Huang B., Jan Y.N., Basbaum A.I., Jan L.Y., Ostertag E.M., Nuwal T.", "date": "2013", "pmid": "23872594" }, { "title": "Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23532839", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1/publications", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Nagata S., Suzuki J., Fujii T., Ishihara K., Imao T., Kuba H.", "date": "2013", "pmid": "23532839" }, { "title": "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22302790", "journal": "Exp. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1/publications", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Gray M.A., Winpenny J.P.", "date": "2012", "pmid": "22302790" }, { "title": "Expression and function of epithelial anoctamins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20056604", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1/publications", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Kunzelmann K., Schreiber R., Kongsuphol P., Martins J.R., Mirza M., Uliyakina I., Warth R.", "date": "2010", "pmid": "20056604" }, { "title": "Expression patterns of the Tmem16 gene family during cephalic development in the mouse.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19059364", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ], "authors": "Gritli-Linde A, Vaziri Sani F, Rock JR, Hallberg K, Iribarne D, Harfe BD, Linde A", "date": "2009", "pmid": "19059364" }, { "title": "Expression of TMEM16 paralogs during murine embryogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18729231", "journal": "Developmental dynamics : an official publication of the American Association of Anatomists", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AHL1/publications", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Rock JR, Harfe BD", "date": "2008", "pmid": "18729231" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 425, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 448, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 455, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 866, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1#A2AHL1-1", "isoform_ac": "A2AHL1-1", "locus": { "end_pos": 110658143, "start_pos": 110950103, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099623", "id": "ENSMUST00000099623", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097219", "id": "ENSMUSP00000097219", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AHL1-1|ANO3_MOUSE Isoform 1 of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 981, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP" } }, { "url": "https://www.uniprot.org/uniprot/A2AHL1#A2AHK9-1", "isoform_ac": "A2AHK9-1", "locus": { "end_pos": 110713278, "start_pos": 110761564, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000140777", "id": "ENSMUST00000140777", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122387", "id": "ENSMUSP00000122387", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AHK9-1|ANO3_MOUSE Computationally mapped isoform of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 181, "sequence": "GAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWAPGRICRSPFHTCCGLFETQDMNTSNIPQDPWLLIGQHMKEPV" } }, { "url": "https://www.uniprot.org/uniprot/A2AHL1#A2AHL1-2", "isoform_ac": "A2AHL1-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AHL1-2|ANO3_MOUSE Isoform 2 of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 637, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLGKFIFLILLVVSK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:228432", "resource": "KEGG Pathway", "id": "mmu:228432", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2672351", "resource": "Reactome", "id": "R-MMU-2672351", "name": "Stimuli-sensing channels" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1#function", "annotation": "Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1#function", "id": "A2AHL1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "annotation": "During mouse cephalic development: detectable in the subventricular zone and differentiating fields, patent in the submandibular autonomic ganglia, detected in osteoblasts and chondrocytes, in palate, tooth and tongue", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "annotation": "Data report the expression of Tmem16c during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M0A0-1", "protein_name": "Anoctamin.", "sequence": { "length": 972, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSEFCLALGKDKDYMDESEHANYDRSRLLNDFVTKDKPESKTKLSKNDMNYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEIINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQNEWP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AHL1/", "id": "A2AHL1", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9BYT9-1", "protein_name": "Anoctamin-3; Transmembrane protein 16C.", "sequence": { "length": 981, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AHL1/", "id": "A2AHL1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/57147", "id": "57147", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "ac": "NP_001121575.1", "name": "anoctamin-3 isoform 1; ano3.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "phospholipid scramblase activity", "id": "GO:0017128" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "protein dimerization activity", "id": "GO:0046983" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061590", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "calcium activated phosphatidylcholine scrambling", "id": "GO:0061590" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061591", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "calcium activated galactosylceramide scrambling", "id": "GO:0061591" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016048", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "detection of temperature stimulus", "id": "GO:0016048" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050982", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "detection of mechanical stimulus", "id": "GO:0050982" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 20, "annotation": "n_glycosylation_sequon", "start_pos": 18 }, { "end_pos": 243, "annotation": "n_glycosylation_sequon", "start_pos": 241 }, { "end_pos": 304, "annotation": "n_glycosylation_sequon", "start_pos": 302 }, { "end_pos": 335, "annotation": "n_glycosylation_sequon", "start_pos": 333 }, { "end_pos": 427, "annotation": "n_glycosylation_sequon", "start_pos": 425 }, { "end_pos": 450, "annotation": "n_glycosylation_sequon", "start_pos": 448 }, { "end_pos": 457, "annotation": "n_glycosylation_sequon", "start_pos": 455 }, { "end_pos": 652, "annotation": "n_glycosylation_sequon", "start_pos": 650 }, { "end_pos": 868, "annotation": "n_glycosylation_sequon", "start_pos": 866 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2672351", "id": "R-MMU-2672351", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:228432", "id": "mmu:228432", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074968", "id": "ENSMUSG00000074968", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/ARIHHFT/", "id": "ARIHHFT", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007632", "id": "IPR007632", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032394", "id": "IPR032394", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031292", "id": "IPR031292", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF04547", "id": "PF04547", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16178", "id": "PF16178", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308", "id": "PTHR12308", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12308:SF16", "id": "PTHR12308:SF16", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AHL1", "id": "PR_A2AHL1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228432", "id": "228432", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3613666", "id": "3613666", "database": "MGI" }, { "url": "https://acgg.asia/gpdb2/GPDB0001651", "id": "GPDB0001651", "database": "GlycoProtDB" } ], "expression_disease": [], "uniprot_ac": "A2AHL1", "disease": [], "mass": { "monoisotopic_mass": 114568.0, "chemical_mass": 114568.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "name": "Ano3; Tmem16c; AI838058; B230324K02Rik.", "locus": { "end_pos": 110655201, "start_pos": 110950923, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074968", "id": "ENSMUSG00000074968", "database": "Ensembl Gene" } ] } } ] }