{ "uniprot_canonical_ac": "A2AGX3-1", "sequence": { "header": "sp|A2AGX3-1|PRD11_MOUSE Isoform 1 of PR domain-containing protein 11 OS=Mus musculus OX=10090 GN=Prdm11 PE=1 SV=1 CANONICAL=A2AGX3-1", "length": 565, "sequence": "MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDAGGESDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGERLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKAEQALENPEDLRGPTQFPVLKQGRSPYKRSFDEGDIHPQAKKKKIDLIFKDVLEASLESGNVEARQLALSTSLVIRKVPKYQDDDYGRAALTQGICRTPGEGDWKVPQRVAKELGPLEDEEEEPTSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPSLLPPQVLELPEFSDPAGKFLRMRLLLKGRVCSATRAHCVEGGPERSALSQPPARRPEECNSAEAAPSWGGSPVPQVTEAGWLEDRGREGIACANLYILLVNKICPICRRAVCCVLDLVFSLGGGAHCCLP" }, "uniprot_id": "PRD11_MOUSE", "enzyme_annotation": [ { "ec": "2.1.1.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "PR domain-containing protein 11 isoform 3", "PR domain-containing protein 11; zinc finger protein 862 pseudogene" ], "uniprotkb": [ "PR domain-containing protein 11", "2.1.1.-" ] }, "gene": { "refseq": [ "Prdm11", "8030443D09Rik", "AA163972", "Gm29694", "Gm707" ], "uniprotkb": [ "Prdm11", "8030443D09Rik", "AA163972", "Gm29694", "Gm707" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "PR domain-containing protein 11; 2.1.1.-." }, "publication": [ { "title": "Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26263558", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "id": "NP_001171007.1", "database": "RefSeq" } ], "authors": "Horsch M, Aguilar-Pimentel JA, Bonisch C, Come C, Kolster-Fog C, Jensen KT, Lund AH, Lee I, Grossman LI, Sinkler C, Huttemann M, Bohn E, Fuchs H, Ollert M, Gailus-Durner V, de Angelis MH, Beckers J", "date": "2015", "pmid": "26263558" }, { "title": "Loss of PRDM11 promotes MYC-driven lymphomagenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25499759", "journal": "Blood", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "id": "NP_001171007.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AGX3/publications", "id": "A2AGX3", "database": "UniProtKB" } ], "authors": "Fog CK, Asmar F, Come C, Jensen KT, Johansen JV, Kheir TB, Jacobsen L, Friis C, Louw A, Rosgaard L, Obro NF, Marquart HV, Anthonsen K, Braat AK, van Lohuizen M, Ralfkiaer E, Gronbaek K, Lund AH", "date": "2015", "pmid": "25499759" }, { "title": "PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23978475", "journal": "Stem cell research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "id": "NP_001171007.1", "database": "RefSeq" } ], "authors": "Thoren LA, Fog CK, Jensen KT, Buza-Vidas N, Come C, Lund AH, Porse BT", "date": "2013", "pmid": "23978475" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3#A2AGX3-1", "isoform_ac": "A2AGX3-1", "locus": { "end_pos": 92974909, "start_pos": 93013883, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000178666", "id": "ENSMUST00000178666", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000136795", "id": "ENSMUSP00000136795", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AGX3-1|PRD11_MOUSE Isoform 1 of PR domain-containing protein 11 OS=Mus musculus OX=10090 GN=Prdm11 PE=1 SV=1 CANONICAL=A2AGX3-1", "length": 565, "sequence": "MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDAGGESDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGERLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKAEQALENPEDLRGPTQFPVLKQGRSPYKRSFDEGDIHPQAKKKKIDLIFKDVLEASLESGNVEARQLALSTSLVIRKVPKYQDDDYGRAALTQGICRTPGEGDWKVPQRVAKELGPLEDEEEEPTSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPSLLPPQVLELPEFSDPAGKFLRMRLLLKGRVCSATRAHCVEGGPERSALSQPPARRPEECNSAEAAPSWGGSPVPQVTEAGWLEDRGREGIACANLYILLVNKICPICRRAVCCVLDLVFSLGGGAHCCLP" } }, { "url": "https://www.uniprot.org/uniprot/A2AGX3#A0A0A0MQD9-1", "isoform_ac": "A0A0A0MQD9-1", "locus": { "end_pos": 92986236, "start_pos": 93013391, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000111272", "id": "ENSMUST00000111272", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106903", "id": "ENSMUSP00000106903", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MQD9-1|PRD11_MOUSE Computationally mapped isoform of PR domain-containing protein 11 OS=Mus musculus OX=10090 GN=Prdm11 PE=1 SV=1 CANONICAL=A2AGX3-1", "length": 461, "sequence": "MEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDAGGESDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRNVLPLAERKRKPKFSKEELDILVTEVTRHEAVLFGRETMRLSHADRDKIWEGIARKITSVSQVPRSIKDIKHRWDDMKRRTKDKLAFMRQSLSGPGIGGHTYPIMLAAHERAIEAALLTTRAGHGFPRAELDGTDSPSTSYDEDEEAPGPSQQPLRMPLLRPPEEEAPLARPTLLYSSSSDPSKMLDPKPEVLPHPSLQARRTPEPHPSSPTLGLDWHLLHAHAHQTEMFQKFCQELMTVHRDMAGSMHVISQAMAELNSRVGQMCETLMEIRDAVQASQRGPEGAAPMDHTFQSQAPLLGPTPAPPEPAPIRTTRSRKRKHNF" } }, { "url": "https://www.uniprot.org/uniprot/A2AGX3#A0A0A0MQL7-1", "isoform_ac": "A0A0A0MQL7-1", "locus": { "end_pos": 93012627, "start_pos": 93013883, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000147339", "id": "ENSMUST00000147339", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122809", "id": "ENSMUSP00000122809", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MQL7-1|PRD11_MOUSE Computationally mapped isoform of PR domain-containing protein 11 OS=Mus musculus OX=10090 GN=Prdm11 PE=1 SV=1 CANONICAL=A2AGX3-1", "length": 162, "sequence": "MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDAGGESDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100042784", "resource": "KEGG Pathway", "id": "mmu:100042784", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3#function", "annotation": "May be involved in transcription regulation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3#function", "id": "A2AGX3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "annotation": "We characterize PRDM11 as a putative novel tumor suppressor that controls the expression of key oncogenes, and we add new mechanistic insight into B-cell lymphomagenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "id": "NP_001171007.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "annotation": "PRDM11, in contrast to PRDM3 and PRDM16, is not directly involved in regulation of HSPCs in mice.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "id": "NP_001171007.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9NQV5-1", "protein_name": "PR domain-containing protein 11; 2.1.1.-.", "sequence": { "length": 511, "sequence": "MLKMAEPIASLMIVECRACLRCSPLFLYQREKDRMTENMKECLAQTNAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRPDSSAMEVEPKKLKGKRDLIVPKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKSEQVLDNPEDLRGPIHLSVLRQGKSPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKVPKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELPEFSDPAGKLVWMRLLSEGRVRSGLCGG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/82511", "id": "82511", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4A985-1", "protein_name": "PR/SET domain 11.", "sequence": { "length": 1172, "sequence": "MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPTHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKEVGGESDVRCINEVVPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGERLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKAEQALDNPEDLRGPSHFPVLKQGRSPYKRSFDEGDLHPQAKKKKIDLIFKDVLEASLESANAEGRQLALSTSLVIRKVPKYQDDDYGRAALTQGICRTPGEGDWKVPQKVAKELGPLEDEEEEHTSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKVPEPPILPQQVLELPEFSDPAASESMVSCPAIMEDDDQEVDSADESVSNDVMTATDEPSKLSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEMCRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAFAALGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAVRWIIGEQNVLNALIKDYLEVVAHLKDVSSQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYIFQGEYLLVSQVDDKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAEAKFQSIREKICQKTQVILAQRFDSRSRVFVKACQVFDLAAWPRNNEELLSFGKEDMVQIFDHLEAIPAFSRDVCREGMDPRGSLLMEWRDLKADYYTKNGFKDLISHICKYKQRFPLLNKIIQVLKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIASFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALEQKPMLQAVDHGSEFYPDM" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/82511", "id": "82511", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "ac": "NP_001171007.1", "name": "PR domain-containing protein 11 isoform 3; PR domain-containing protein 11; zinc finger protein 862 pseudogene.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "chromatin DNA binding", "id": "GO:0031490" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "methyltransferase activity", "id": "GO:0008168" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001047", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "core promoter binding", "id": "GO:0001047" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "negative regulation of cell growth", "id": "GO:0030308" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000271", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "positive regulation of fibroblast apoptotic process", "id": "GO:2000271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "regulation of cell cycle", "id": "GO:0051726" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "id": "A2AGX3", "database": "UniProtKB" } ], "name": "regulation of MAPK cascade", "id": "GO:0043408" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007.1", "id": "NP_001171007.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100042784", "id": "mmu:100042784", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000075028", "id": "ENSMUSG00000075028", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WMRYVII/", "id": "WMRYVII", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "id": "IPR001214", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00856", "id": "PF00856", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AGX3", "id": "PR_A2AGX3", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/100042784", "id": "100042784", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2685553", "id": "2685553", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AGX3", "disease": [], "mass": { "monoisotopic_mass": 63383.0, "chemical_mass": 63383.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AGX3", "name": "Prdm11; 8030443D09Rik; AA163972; Gm29694; Gm707.", "locus": { "end_pos": 92965151, "start_pos": 93046167, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000075028", "id": "ENSMUSG00000075028", "database": "Ensembl Gene" } ] } } ] }