{ "uniprot_canonical_ac": "A2AGH6-1", "sequence": { "header": "sp|A2AGH6-1|MED12_MOUSE Isoform 1 of Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 CANONICAL=A2AGH6-1", "length": 2190, "sequence": "MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" }, "uniprot_id": "MED12_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "mediator of RNA polymerase II transcription subunit 12", "trinucleotide repeat containing 11 (THR-associated protein); OPA-containing protein 1; trinucleotide repeat-containing gene 11 protein; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); mediator of RNA polymerase II transcription, subunit 12 homolog" ], "uniprotkb": [ "Mediator of RNA polymerase II transcription subunit 12", "Thyroid hormone receptor-associated protein complex 230 kDa component", "Trap230", "Trinucleotide repeat-containing gene 11 protein", "Mediator complex subunit 12", "OPA-containing protein" ] }, "gene": { "refseq": [ "Med12", "230kDa", "Mopa", "OPA-1", "Tnrc11", "Trap230" ], "uniprotkb": [ "Med12", "Trap230", "Kiaa0192", "Mopa", "Tnrc11", "230kDa", "OPA-1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Mediator of RNA polymerase II transcription subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein; Mediator complex subunit 12; OPA-containing protein." }, "publication": [ { "title": "Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29126187", "journal": "Biology of reproduction", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Wang X, Mittal P, Castro CA, Rajkovic G, Rajkovic A", "date": "2017", "pmid": "29126187" }, { "title": "Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27188461", "journal": "BMC developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Kim NH, Livi CB, Yew PR, Boyer TG", "date": "2016", "pmid": "27188461" }, { "title": "MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27570068", "journal": "Cell stem cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Aranda-Orgilles B, Saldana-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sanchez-Diaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I", "date": "2016", "pmid": "27570068" }, { "title": "Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27096886", "journal": "Cell cycle (Georgetown, Tex.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Papadopoulou T, Kaymak A, Sayols S, Richly H", "date": "2016", "pmid": "27096886" }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6/publications", "id": "A2AGH6", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014", "pmid": "24129315" }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23806337", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6/publications", "id": "A2AGH6", "database": "UniProtKB" } ], "authors": "Chen Y., Park J., Zhang Y., Zhao Y., Peng C., Tan M., Xie Z., Zwaans B.M., Lombard D.B., Dai L., Tishkoff D.X., Skinner M.E.", "date": "2013", "pmid": "23806337" }, { "title": "Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15340084", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Malik S, Guermah M, Yuan CX, Wu W, Yamamura S, Roeder RG", "date": "2004", "pmid": "15340084" }, { "title": "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12037571", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG", "date": "2002", "pmid": "12037571" }, { "title": "Association of an X-chromosome dodecamer insertional variant allele with mental retardation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9702738", "journal": "Mol. Psychiatry", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6/publications", "id": "A2AGH6", "database": "UniProtKB" } ], "authors": "Palotie A., Ginns E.I., Martin B.M., Lee Y.-H., Damschroder-Williams P., Stubblefield B., Cook E.H., Dea C., King B.H., Philibert R.A., Tengstrom C.", "date": "1998", "pmid": "9702738" }, { "title": "DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/2885744", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ], "authors": "Duboule D, Haenlin M, Galliot B, Mohier E", "date": "1987", "pmid": "2885744" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6#A2AGH6-1", "isoform_ac": "A2AGH6-1", "locus": { "end_pos": 101274261, "start_pos": 101297227, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000087948", "id": "ENSMUST00000087948", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000085260", "id": "ENSMUSP00000085260", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AGH6-1|MED12_MOUSE Isoform 1 of Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 CANONICAL=A2AGH6-1", "length": 2190, "sequence": "MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" } }, { "url": "https://www.uniprot.org/uniprot/A2AGH6#A2AGH8-1", "isoform_ac": "A2AGH8-1", "locus": { "end_pos": 101274261, "start_pos": 101297227, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000117706", "id": "ENSMUST00000117706", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000112852", "id": "ENSMUSP00000112852", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AGH8-1|MED12_MOUSE Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 CANONICAL=A2AGH6-1", "length": 2157, "sequence": "MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" } }, { "url": "https://www.uniprot.org/uniprot/A2AGH6#A2AGH6-2", "isoform_ac": "A2AGH6-2", "locus": { "end_pos": 101274261, "start_pos": 101297227, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000087956", "id": "ENSMUST00000087956", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000085269", "id": "ENSMUSP00000085269", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AGH6-2|MED12_MOUSE Isoform 2 of Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 CANONICAL=A2AGH6-1", "length": 2169, "sequence": "MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQLSSPSLQGYTSYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" } }, { "url": "https://www.uniprot.org/uniprot/A2AGH6#A2AGH9-1", "isoform_ac": "A2AGH9-1", "locus": { "end_pos": 101274261, "start_pos": 101297227, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000117203", "id": "ENSMUST00000117203", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000112729", "id": "ENSMUSP00000112729", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AGH9-1|MED12_MOUSE Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 CANONICAL=A2AGH6-1", "length": 2182, "sequence": "MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" } }, { "url": "https://www.uniprot.org/uniprot/A2AGH6#A2AGH6-3", "isoform_ac": "A2AGH6-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AGH6-3|MED12_MOUSE Isoform 3 of Mediator of RNA polymerase II transcription subunit 12 OS=Mus musculus OX=10090 GN=Med12 PE=1 SV=1 CANONICAL=A2AGH6-1", "length": 866, "sequence": "MQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:59024", "resource": "KEGG Pathway", "id": "mmu:59024", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "resource": "Reactome", "id": "R-MMU-212436", "name": "Generic Transcription Pathway" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6#function", "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6#function", "id": "A2AGH6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "annotation": "Med12 is critically important in reproductive tract development, and Med12 loss of function does not cause tumorigenesis in reproductive tissues.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "annotation": "Alterations in MED12-dependent enhancer regulation may control both physiological and malignant hematopoiesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "annotation": "The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "annotation": "Study provide evidence that Med12 regulates neural stem cell gene expression programs linked to adhesion and cell cycle progression but suppresses its adhesion by repressing the expression of cell adhesion molecules. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q93074-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Activator-recruited cofactor 240 kDa component; ARC240; Trinucleotide repeat-containing gene 11 protein; Mediator complex subunit 12; OPA-containing protein; CAG repeat protein 45.", "sequence": { "length": 2177, "sequence": "MAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68441", "id": "68441", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "A0A096MKF8-1", "protein_name": "Mediator complex subunit 12.", "sequence": { "length": 2190, "sequence": "MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGVCGSAIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVNSHSSHVISAQSTSSLPTTPAPQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGTPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFVFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDSEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQSSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQPQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68441", "id": "68441", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "ac": "NP_067496.2", "name": "mediator of RNA polymerase II transcription subunit 12; trinucleotide repeat containing 11 (THR-associated protein); OPA-containing protein 1; trinucleotide repeat-containing gene 11 protein; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); mediator of RNA polymerase II transcription, subunit 12 homolog.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "transcription coactivator activity", "id": "GO:0003713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000980", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "RNA polymerase II distal enhancer sequence-specific DNA binding", "id": "GO:0000980" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008022", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "protein C-terminus binding", "id": "GO:0008022" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "beta-catenin binding", "id": "GO:0008013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046966", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "thyroid hormone receptor binding", "id": "GO:0046966" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "transcription coregulator activity", "id": "GO:0003712" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "mediator complex", "id": "GO:0016592" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "mediator complex", "id": "GO:0016592" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "ubiquitin ligase complex", "id": "GO:0000151" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "heart development", "id": "GO:0007507" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "spinal cord development", "id": "GO:0021510" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "neural tube closure", "id": "GO:0001843" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "neural tube development", "id": "GO:0021915" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001756", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "somitogenesis", "id": "GO:0001756" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "stem cell population maintenance", "id": "GO:0019827" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "canonical Wnt signaling pathway", "id": "GO:0060070" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060071", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "Wnt signaling pathway, planar cell polarity pathway", "id": "GO:0060071" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007492", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "endoderm development", "id": "GO:0007492" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "oligodendrocyte development", "id": "GO:0014003" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048568", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "embryonic organ development", "id": "GO:0048568" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990403", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "embryonic brain development", "id": "GO:1990403" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014044", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "Schwann cell development", "id": "GO:0014044" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048702", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "embryonic neurocranium morphogenesis", "id": "GO:0048702" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036342", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "post-anal tail morphogenesis", "id": "GO:0036342" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090245", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "axis elongation involved in somitogenesis", "id": "GO:0090245" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "id": "A2AGH6", "database": "UniProtKB" } ], "name": "transcription initiation from RNA polymerase II promoter", "id": "GO:0006367" } ], "total": 21, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 74, "annotation": "n_glycosylation_sequon", "start_pos": 72 }, { "end_pos": 963, "annotation": "n_glycosylation_sequon", "start_pos": 961 }, { "end_pos": 1108, "annotation": "n_glycosylation_sequon", "start_pos": 1106 }, { "end_pos": 1270, "annotation": "n_glycosylation_sequon", "start_pos": 1268 }, { "end_pos": 1594, "annotation": "n_glycosylation_sequon", "start_pos": 1592 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496.2", "id": "NP_067496.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "id": "R-MMU-212436", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:59024", "id": "mmu:59024", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079487", "id": "ENSMUSG00000079487", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019035", "id": "IPR019035", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021989", "id": "IPR021989", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021990", "id": "IPR021990", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF09497", "id": "PF09497", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12144", "id": "PF12144", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12145", "id": "PF12145", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AGH6", "id": "PR_A2AGH6", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AGH6*", "id": "A2AGH6", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/59024", "id": "59024", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1926212", "id": "1926212", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AGH6", "disease": [], "mass": { "monoisotopic_mass": 244561.0, "chemical_mass": 244561.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AGH6", "name": "Med12; Trap230; Kiaa0192; Mopa; Tnrc11; 230kDa; OPA-1.", "locus": { "end_pos": 101297465, "start_pos": 101274030, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000079487", "id": "ENSMUSG00000079487", "database": "Ensembl Gene" } ] } } ] }