{ "uniprot_canonical_ac": "A2ACJ2-1", "sequence": { "header": "sp|A2ACJ2-1|FP100_MOUSE Isoform 1 of Fanconi anemia core complex-associated protein 100 OS=Mus musculus OX=10090 GN=Faap100 PE=2 SV=1 CANONICAL=A2ACJ2-1", "length": 879, "sequence": "MAGASSRVHYLSDFCCPLGGRAAGKPFVLRHEAEVFLSTGREFVYVYDQEGGLLTAVYQFPDQVWHLQLLAIRRALYVLCARTGIYCLSLDSLDRSGSQACEDKEEAAPPYPVIHVDPDACVLPDAALCAFTVLDDMLVTLAQGPTQWKMQLFERPCAGEEPLPRGQIGEVELSTCTPPGGVPEKPAAPRFLPVLCCVFPPDSRAPHGHPQGCGCFTLEEALFGLLFGVDATLLQSPVILCGLPDGQLCCVVLKALVTSGLAPGDPKVLVKILHHLEEPVIFIGALRAEPHEEEAAGELLPGQHEHSDCLVALGHQGRTLAIKASWSESGNLVPELREYCLPGPVLCAACDRDGHVYHSTPSDLCVVDLTRRDSPWNPEKPDGAIGGLPSVLCPASLNICSALALCVTARAPTGSTELLALSSKGRLITCSLDLNSEAPVPAKMAMANAGQKIKELLLDIGDVSERVSFLKKAVDQRNKAITSLNEAMNVSCALLSHPEGDRPIACTITTSWSRLELRDMLMATCTLENSSSFSLDQGWTLCIQVLTSSSALDLDGTGSAFTYTIPVDRLGPGSRREVTLPLGPSESGVLDLPVTMSCWLFYSLREVVGAALAPSDPLEAPYLEQFPLSLPKQEGVCLPLCKRTVDMLQCLRFAGAATHPAQAPCMPGPACEPVETFLKTCQAPGSEPTGAASLRAKYLPPSTASIRVSAGLLRAALEDSHSGFHLCSATLRWLLAENAAVDVVRAQTLSSIQGIAPDGTDVNLTVHEVAVTDLSPAGPIQAVEIQVESSSLANMCRAHHAIIRRIQTMVTEQAALGSSPPDLRMQYLQQIHANHQELLREVQALRDQLCTEDELSSCSTAQKLLHIYKQLRNPSLVLL" }, "uniprot_id": "FP100_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "Fanconi anemia core complex-associated protein 100", "fanconi anemia-associated protein of 100 kDa" ], "uniprotkb": [ "Fanconi anemia core complex-associated protein 100", "Fanconi anemia-associated protein of 100 kDa" ] }, "gene": { "refseq": [ "Faap100", "2310003H01Rik" ], "uniprotkb": [ "Faap100", "2310003H01Rik" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Fanconi anemia core complex-associated protein 100; Fanconi anemia-associated protein of 100 kDa." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2#A2ACJ2-1", "isoform_ac": "A2ACJ2-1", "locus": { "end_pos": 120370291, "start_pos": 120378706, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000026448", "id": "ENSMUST00000026448", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000026448", "id": "ENSMUSP00000026448", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ACJ2-1|FP100_MOUSE Isoform 1 of Fanconi anemia core complex-associated protein 100 OS=Mus musculus OX=10090 GN=Faap100 PE=2 SV=1 CANONICAL=A2ACJ2-1", "length": 879, "sequence": "MAGASSRVHYLSDFCCPLGGRAAGKPFVLRHEAEVFLSTGREFVYVYDQEGGLLTAVYQFPDQVWHLQLLAIRRALYVLCARTGIYCLSLDSLDRSGSQACEDKEEAAPPYPVIHVDPDACVLPDAALCAFTVLDDMLVTLAQGPTQWKMQLFERPCAGEEPLPRGQIGEVELSTCTPPGGVPEKPAAPRFLPVLCCVFPPDSRAPHGHPQGCGCFTLEEALFGLLFGVDATLLQSPVILCGLPDGQLCCVVLKALVTSGLAPGDPKVLVKILHHLEEPVIFIGALRAEPHEEEAAGELLPGQHEHSDCLVALGHQGRTLAIKASWSESGNLVPELREYCLPGPVLCAACDRDGHVYHSTPSDLCVVDLTRRDSPWNPEKPDGAIGGLPSVLCPASLNICSALALCVTARAPTGSTELLALSSKGRLITCSLDLNSEAPVPAKMAMANAGQKIKELLLDIGDVSERVSFLKKAVDQRNKAITSLNEAMNVSCALLSHPEGDRPIACTITTSWSRLELRDMLMATCTLENSSSFSLDQGWTLCIQVLTSSSALDLDGTGSAFTYTIPVDRLGPGSRREVTLPLGPSESGVLDLPVTMSCWLFYSLREVVGAALAPSDPLEAPYLEQFPLSLPKQEGVCLPLCKRTVDMLQCLRFAGAATHPAQAPCMPGPACEPVETFLKTCQAPGSEPTGAASLRAKYLPPSTASIRVSAGLLRAALEDSHSGFHLCSATLRWLLAENAAVDVVRAQTLSSIQGIAPDGTDVNLTVHEVAVTDLSPAGPIQAVEIQVESSSLANMCRAHHAIIRRIQTMVTEQAALGSSPPDLRMQYLQQIHANHQELLREVQALRDQLCTEDELSSCSTAQKLLHIYKQLRNPSLVLL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:71885", "resource": "KEGG Pathway", "id": "mmu:71885", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6783310", "resource": "Reactome", "id": "R-MMU-6783310", "name": "Fanconi Anemia Pathway" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2#function", "annotation": "Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2#function", "id": "A2ACJ2", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q0VG06-1", "protein_name": "Fanconi anemia core complex-associated protein 100; Fanconi anemia-associated protein of 100 kDa.", "sequence": { "length": 881, "sequence": "MAGAAPRVRYLAGFCCPLGGLAAGKPRVLCHEAEVFLSTGSELVYVYDQEGGLLTAAFRFPDQVWHLELLAPRRLLYALCARRGLYCLSLDHPGRSRSTSQDDRDSEDGDQPSPVIPVDPDACILPDAALCAFTLLDSVLVTLVQGPARWKMQLFEQPCPGEDPRPGGQIGEVELSSYTPPAGVPGKPAAPHFLPVLCSVSPSGSRVPHDLLGGSGGFTLEDALFGLLFGADATLLQSPVVLCGLPDGQLCCVILKALVTSRSAPGDPNALVKILHHLEEPVIFIGALKTEPQAAEAAENFLPDEDVHCDCLVAFGHHGRMLAIKASWDESGKLVPELREYCLPGPVLCAACGGGGRVYHSTPSDLCVVDLSRGSTPLGPEQPEEGPGGLPPMLCPASLNICSVVSLSASPRTHEGGTKLLALSAKGRLMTCSLDLDSEMPGPARMTTESAGQKIKELLSGIGNISERVSFLKKAVDQRNKALTSLNEAMNVSCALLSSGTGPRPISCTTSTTWSRLQTQDVLMATCVLENSSSFSLDQGWTLCIQVLTSSCALDLDSACSAITYTIPVDQLGPGARREVTLPLGPGENGGLDLPVTVSCTLFYSLREVVGGALAPSDSEDPFLDECPSDVLPEQEGVCLPLSRHTVDMLQCLRFPGLAPPHTRAPSPLGPTRDPVATFLETCREPGSQPAGPASLRAEYLPPSVASIKVSAELLRAALKDGHSGVPLCCATLQWLLAENAAVDVVRARALSSIQGVAPDGANVHLIVREVAMTDLCPAGPIQAVEIQVESSSLADICRAHHAVVGRMQTMVTEQATQGSSAPDLRVQYLRQIHANHETLLREVQTLRDRLCTEDEASSCATAQRLLQVYRQLRHPSLILL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2ACJ2/", "id": "A2ACJ2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/69394", "id": "69394", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZX03-1", "protein_name": "FA core complex-associated protein 100.", "sequence": { "length": 882, "sequence": "MAGASSRVHYLSDFCCPLGGRAAGKPHVLRHDAEVFLSTGREFVYVYDQEGGLLTAVYQFPDQVWHLQLLATRRALYVLCARTGIYCLSLDSLDRSGSQACEDKEDETHPYPVIHVDPDACVLPDAALCAFTVLDDVLVTLAQGPTQWKMQLFECPHAGEEPRPGGQVGEVQLSTCTPPGGVPGEPTAPCFLPVLCCVFPPDSRAPHGHPQGCGCFMLEEALFGLLFGVDASLLQSPVVLCGLPDGQLCCVALKALVTSELAPGDPKVLVKILHHLEEPVIFIGALRAEPQEEEEEEAVRELLPVENVHSDCLVALGHQGRTLAIRASWSESGNLVPELREYYLPGPVLCAACGRDGHMYHSTPSDLCVVDLTRRDSTWNPEKPDGAIGSLPSTLCPASLNICSALALCVTARAPTGGTELLVLSSKGRLITCSLDLNPEAPVPTKMAVANAGQKIKELLLDIGDVSERVSFLKKAVDQRNKAITSLNEAMNVSCALLSSQEGDRPISCTITTSWSRLELRDMLMATCTLDNSSSFSLDQGWTLCIQVLTSSSALDLDGTGSAFTYTIPVDRLGPGSRREVTLPLGPSESGVLDLPVTMSCWLFYSLREVIGEALAPSDPLEVPYLEKLPLNLPKQEGVCLPLCKRTVDMLQCLRFPGVASHPAQAPSVPGPACDPVETFLKTCQGPGSEPTGAASLRAKYLPPSTASIRVSAGLLRAALEDGHSGFHLCSATLCWLLAENAAVDVLRAQALSSIQGIAPDGTDVNLIVHEVAVTDLSPAGPIQAVEIQVESSSLANMCRAHHAIIRRIKTMVTEQAAQGSSPPDLRMQYLQQIHANHQELLREVQTLRDQLCTEDEVSSCSTAQKLLQIYKQLRNPSLVLL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2ACJ2/", "id": "A2ACJ2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/69394", "id": "69394", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082256.2", "ac": "NP_082256.2", "name": "Fanconi anemia core complex-associated protein 100; fanconi anemia-associated protein of 100 kDa.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "intermediate filament cytoskeleton", "id": "GO:0045111" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "id": "A2ACJ2", "database": "UniProtKB" } ], "name": "interstrand cross-link repair", "id": "GO:0036297" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 491, "annotation": "n_glycosylation_sequon", "start_pos": 489 }, { "end_pos": 531, "annotation": "n_glycosylation_sequon", "start_pos": 529 }, { "end_pos": 765, "annotation": "n_glycosylation_sequon", "start_pos": 763 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082256.2", "id": "NP_082256.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6783310", "id": "R-MMU-6783310", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:71885", "id": "mmu:71885", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025384", "id": "ENSMUSG00000025384", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/MQLFERP/", "id": "MQLFERP", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029251", "id": "IPR029251", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF15146", "id": "PF15146", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14890", "id": "PTHR14890", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ACJ2", "id": "PR_A2ACJ2", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ACJ2*", "id": "A2ACJ2", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/71885", "id": "71885", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1919135", "id": "1919135", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2ACJ2", "disease": [], "mass": { "monoisotopic_mass": 94281.0, "chemical_mass": 94281.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ACJ2", "name": "Faap100; 2310003H01Rik.", "locus": { "end_pos": 120369055, "start_pos": 120378764, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000025384", "id": "ENSMUSG00000025384", "database": "Ensembl Gene" } ] } } ] }