{
    "uniprot_canonical_ac": "A2AA28-1", 
    "sequence": {
        "header": "sp|A2AA28-1|MET23_MOUSE Isoform 1 of Methyltransferase-like protein 23  OS=Mus musculus OX=10090 GN=Mettl23 PE=2 SV=1 CANONICAL=A2AA28-1", 
        "length": 253, 
        "sequence": "MDSVRPRAPWAPPPDPASLDSPTCEPGLMAGTQLFRFREEPVPGGNRAVLEVRVPQVLHVQYGMYVWPCAVVLAQYLWFHRRSLPGKAVLEVGAGVSLPGILAAKCGAKVILSDSSEFPHCLDICRQSCQMNNLPQVEVVGLTWGHISKDILSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKVQFWSTYQVRSADWSLEGLLYKWDMKCVHIPLESFDADKEDIAESTLPGRHTVEMLIISFAKDSF"
    }, 
    "uniprot_id": "MET23_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.1.1.-", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "methyltransferase-like protein 23"
            ], 
            "uniprotkb": [
                "Methyltransferase-like protein 23", 
                "2.1.1.-"
            ]
        }, 
        "gene": {
            "refseq": [
                "Mettl23", 
                "1110005A03Rik", 
                "1500035B17Rik", 
                "4933424L15Rik"
            ], 
            "uniprotkb": [
                "Mettl23", 
                "1110005A03Rik", 
                "1500035B17Rik", 
                "4933424L15Rik"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AA28", 
                    "id": "A2AA28", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Methyltransferase-like protein 23; 2.1.1.-."
    }, 
    "publication": [
        {
            "title": "Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18564434", 
            "journal": "BMC genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083141.3", 
                    "id": "NP_083141.3", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Hahn P, Bose J, Edler S, Lengeling A", 
            "date": "2008", 
            "pmid": "18564434"
        }, 
        {
            "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083141.3", 
                    "id": "NP_083141.3", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", 
            "date": "2003", 
            "pmid": "12520002"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AA28#A2AA28-1", 
            "isoform_ac": "A2AA28-1", 
            "locus": {
                "end_pos": 116843607, 
                "start_pos": 116849552, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000106370", 
                        "id": "ENSMUST00000106370", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000101978", 
                        "id": "ENSMUSP00000101978", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AA28-1|MET23_MOUSE Isoform 1 of Methyltransferase-like protein 23  OS=Mus musculus OX=10090 GN=Mettl23 PE=2 SV=1 CANONICAL=A2AA28-1", 
                "length": 253, 
                "sequence": "MDSVRPRAPWAPPPDPASLDSPTCEPGLMAGTQLFRFREEPVPGGNRAVLEVRVPQVLHVQYGMYVWPCAVVLAQYLWFHRRSLPGKAVLEVGAGVSLPGILAAKCGAKVILSDSSEFPHCLDICRQSCQMNNLPQVEVVGLTWGHISKDILSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKVQFWSTYQVRSADWSLEGLLYKWDMKCVHIPLESFDADKEDIAESTLPGRHTVEMLIISFAKDSF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AA28#H3BKB2-1", 
            "isoform_ac": "H3BKB2-1", 
            "locus": {
                "end_pos": 116843675, 
                "start_pos": 116845890, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000140869", 
                        "id": "ENSMUST00000140869", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000135321", 
                        "id": "ENSMUSP00000135321", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H3BKB2-1|MET23_MOUSE Computationally mapped isoform of Methyltransferase-like protein 23  OS=Mus musculus OX=10090 GN=Mettl23 PE=2 SV=1 CANONICAL=A2AA28-1", 
                "length": 76, 
                "sequence": "XCEPGLMAGTQLFRFREEPVPGGNRAVLEVRVPQINFLLELMAHALNPSFNPSIQKAEARGSLEFEANIVCTVTTQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AA28#H3BKP4-1", 
            "isoform_ac": "H3BKP4-1", 
            "locus": {
                "end_pos": 116843675, 
                "start_pos": 116845856, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000132593", 
                        "id": "ENSMUST00000132593", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000135469", 
                        "id": "ENSMUSP00000135469", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H3BKP4-1|MET23_MOUSE Computationally mapped isoform of Methyltransferase-like protein 23  OS=Mus musculus OX=10090 GN=Mettl23 PE=2 SV=1 CANONICAL=A2AA28-1", 
                "length": 46, 
                "sequence": "XCEPGLMAGTQLFRFREEPVPGGNRAVLEVRVPQHSKGRGKRITGV"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AA28#B7ZC87-1", 
            "isoform_ac": "B7ZC87-1", 
            "locus": {
                "end_pos": 116848901, 
                "start_pos": 116854091, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000143184", 
                        "id": "ENSMUST00000143184", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119131", 
                        "id": "ENSMUSP00000119131", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|B7ZC87-1|MET23_MOUSE Computationally mapped isoform of Methyltransferase-like protein 23  OS=Mus musculus OX=10090 GN=Mettl23 PE=2 SV=1 CANONICAL=A2AA28-1", 
                "length": 110, 
                "sequence": "VGAGVSLPGILAAKCGAKVILSDSSEFPHCLDICRQSCQMNNLPQVEVVGLTWGHISKDILSLPPQDIILGSDVFFEPEGLSGGSTGGEEVTVLGRCWPLSKRSQNVPGV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:74319", 
            "resource": "KEGG Pathway", 
            "id": "mmu:74319", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AA28#function", 
            "annotation": "Probable methyltransferase.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AA28#function", 
                    "id": "A2AA28", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083141.3", 
            "annotation": "Located immediately downstream of Jmjd6, with a bi-directionar promoter between the two. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083141.3", 
                    "id": "NP_083141.3", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q86XA0-1", 
            "protein_name": "Methyltransferase-like protein 23; 2.1.1.-.", 
            "sequence": {
                "length": 190, 
                "sequence": "MYVWPCAVVLAQYLWFHRRSLPGKAILEIGAGVSLPGILAAKCGAEVILSDSSELPHCLEVCRQSCQMNNLPHLQVVGLTWGHISWDLLALPPQDIILASDVFFEPEDFEDILATIYFLMHKNPKVQLWSTYQVRSADWSLEALLYKWDMKCVHIPLESFDADKEDIAESTLPGRHTVEMLVISFAKDSL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12552", 
                    "id": "12552", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q5RJL2-1", 
            "protein_name": "Methyltransferase-like protein 23; 2.1.1.-.", 
            "sequence": {
                "length": 225, 
                "sequence": "MAGARLFRFRDEPGPGADPTVLEVRVPQVLHVQYGMYVWPCAVVLAQYLWFHRRVLPGKAVLEIGAGVSLPGILAAKCGAKVTLSDSPELPHCLDICWQSCQMNNLPQVQIVGLTWGHISKDTLSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKVQFWSTYQVRSADWSLEGLLYKWDMRCVHIPLESFDADKEDIAESTLPGRHTIEMLIISFAKDSS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12552", 
                    "id": "12552", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2AA28/", 
                    "id": "A2AA28", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083141.3", 
        "ac": "NP_083141.3", 
        "name": "methyltransferase-like protein 23.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "heat shock protein binding", 
                        "id": "GO:0031072"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor binding", 
                        "id": "GO:0008134"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "methyltransferase activity", 
                        "id": "GO:0008168"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein-containing complex", 
                        "id": "GO:0032991"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050890", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AA28", 
                                "id": "A2AA28", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cognition", 
                        "id": "GO:0050890"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083141.3", 
            "id": "NP_083141.3", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:74319", 
            "id": "mmu:74319", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000090266", 
            "id": "ENSMUSG00000090266", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TWPCAPV/", 
            "id": "TWPCAPV", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", 
            "id": "IPR029063", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019410", 
            "id": "IPR019410", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF10294", 
            "id": "PF10294", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AA28", 
            "id": "PR_A2AA28", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/74319", 
            "id": "74319", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1921569", 
            "id": "1921569", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2AA28", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 28289.0, 
        "chemical_mass": 28289.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AA28", 
            "name": "Mettl23; 1110005A03Rik; 1500035B17Rik; 4933424L15Rik.", 
            "locus": {
                "end_pos": 116854263, 
                "start_pos": 116843278, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000090266", 
                        "id": "ENSMUSG00000090266", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}