{ "uniprot_canonical_ac": "A2A9T0-1", "sequence": { "header": "sp|A2A9T0-1|TBKB1_MOUSE Isoform 1 of TANK-binding kinase 1-binding protein 1 OS=Mus musculus OX=10090 GN=Tbkbp1 PE=1 SV=1 CANONICAL=A2A9T0-1", "length": 611, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVEKVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLRQICGLEKQLQQQQGLRDAAFSSLSPPAVPASACPDLDLHYLALRGGPALGHAGWPGPTSVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSECDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQRHSPLSQRHSPAPACPSPSPPARPPPCAPCQSPAAQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERVYAKPPSHHAKAGFQGRRSYSELAEGAAYAGASPAWLQAEAATLPKPRAYGGELYGRPLSPRRAFEGIRLRFEKQPSEEEEWAMPASPPSPEAGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI" }, "uniprot_id": "TBKB1_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "TANK-binding kinase 1-binding protein 1 isoform 1", "TANK-binding kinase 1-binding protein 1; tbkbp1" ], "uniprotkb": [ "TANK-binding kinase 1-binding protein 1", "TBK1-binding protein 1", "Similar to NAP1 TBK1 adapter" ] }, "gene": { "refseq": [ "Tbkbp1", "3110043L15Rik", "ProSAPiP2", "SINTBAD" ], "uniprotkb": [ "Tbkbp1", "Sintbad", "3110043L15Rik", "ProSAPiP2", "SINTBAD" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9T0", "id": "A2A9T0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "TANK-binding kinase 1-binding protein 1; TBK1-binding protein 1; Similar to NAP1 TBK1 adapter.", "short": "TBK1-binding protein 1" }, "publication": [ { "title": "TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30022064", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" } ], "authors": "Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, Shi J, Zhao S, Zhang B, Cheng X, Sun SC", "date": "2018", "pmid": "30022064" }, { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23610142", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" } ], "authors": "Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O", "date": "2013", "pmid": "23610142" }, { "title": "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17568778", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A9T0/publications", "id": "A2A9T0", "database": "UniProtKB" } ], "authors": "Ryzhakov G, Randow F", "date": "2007", "pmid": "17568778" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A9T0#A2A9T0-1", "isoform_ac": "A2A9T0-1", "locus": { "end_pos": 97137550, "start_pos": 97149586, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000066078", "id": "ENSMUST00000066078", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000065461", "id": "ENSMUSP00000065461", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A9T0-1|TBKB1_MOUSE Isoform 1 of TANK-binding kinase 1-binding protein 1 OS=Mus musculus OX=10090 GN=Tbkbp1 PE=1 SV=1 CANONICAL=A2A9T0-1", "length": 611, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVEKVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLRQICGLEKQLQQQQGLRDAAFSSLSPPAVPASACPDLDLHYLALRGGPALGHAGWPGPTSVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSECDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQRHSPLSQRHSPAPACPSPSPPARPPPCAPCQSPAAQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERVYAKPPSHHAKAGFQGRRSYSELAEGAAYAGASPAWLQAEAATLPKPRAYGGELYGRPLSPRRAFEGIRLRFEKQPSEEEEWAMPASPPSPEAGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI" } }, { "url": "https://www.uniprot.org/uniprot/A2A9T0#A2A9T1-1", "isoform_ac": "A2A9T1-1", "locus": { "end_pos": 97148629, "start_pos": 97149586, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000146374", "id": "ENSMUST00000146374", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114460", "id": "ENSMUSP00000114460", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A9T1-1|TBKB1_MOUSE Computationally mapped isoform of TANK-binding kinase 1-binding protein 1 OS=Mus musculus OX=10090 GN=Tbkbp1 PE=1 SV=1 CANONICAL=A2A9T0-1", "length": 151, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVEKVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEM" } }, { "url": "https://www.uniprot.org/uniprot/A2A9T0#A2A9T0-2", "isoform_ac": "A2A9T0-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2A9T0-2|TBKB1_MOUSE Isoform 2 of TANK-binding kinase 1-binding protein 1 OS=Mus musculus OX=10090 GN=Tbkbp1 PE=1 SV=1 CANONICAL=A2A9T0-1", "length": 596, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVEKVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLRQICGLEKQLQQQQGLRDAAFSSLSPPAVPASACPDLDLHYLALRGGPALGHGWPGPTSVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSECDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQRHSPLSQRHSPAPACPSPSPPARPPPCAPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERVYAKPPSHHAKAGFQGRRSYSELAEGAAYAGASPAWLQAEAATLPKPRAYGGELYGRPLSPRRAFEGIRLRFEKQPSEEEEWAMPASPPSPEAGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI" } }, { "url": "https://www.uniprot.org/uniprot/A2A9T0#G3X9S9-1", "isoform_ac": "G3X9S9-1", "locus": { "end_pos": 97147726, "start_pos": 97149586, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107613", "id": "ENSMUST00000107613", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103238", "id": "ENSMUSP00000103238", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3X9S9-1|TBKB1_MOUSE Computationally mapped isoform of TANK-binding kinase 1-binding protein 1 OS=Mus musculus OX=10090 GN=Tbkbp1 PE=1 SV=1 CANONICAL=A2A9T0-1", "length": 153, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVEKVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEMEL" } }, { "url": "https://www.uniprot.org/uniprot/A2A9T0#Z4YKN2-1", "isoform_ac": "Z4YKN2-1", "locus": { "end_pos": 97137550, "start_pos": 97149586, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107615", "id": "ENSMUST00000107615", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103240", "id": "ENSMUSP00000103240", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YKN2-1|TBKB1_MOUSE Computationally mapped isoform of TANK-binding kinase 1-binding protein 1 OS=Mus musculus OX=10090 GN=Tbkbp1 PE=1 SV=1 CANONICAL=A2A9T0-1", "length": 610, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVEKVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLRQICGLEKQLQQQQGLRDAAFSSLSPPAVPASACPDLDLHYLALRGGPALGHGWPGPTSVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSECDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQRHSPLSQRHSPAPACPSPSPPARPPPCAPCQSPAAQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERVYAKPPSHHAKAGFQGRRSYSELAEGAAYAGASPAWLQAEAATLPKPRAYGGELYGRPLSPRRAFEGIRLRFEKQPSEEEEWAMPASPPSPEAGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:73174", "resource": "KEGG Pathway", "id": "mmu:73174", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A9T0#function", "annotation": "Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9T0#function", "id": "A2A9T0", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "annotation": "SINTBAD regulates IL-15-induced autophagy and NKT cell survival. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "annotation": "Results suggest that efficient signal transduction upon viral infection requires SINTBAD, TANK and NAP1 because they link TBK1 and IKKi to virus-activated signalling cascades", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A7MCY6-1", "protein_name": "TANK-binding kinase 1-binding protein 1; TBK1-binding protein 1.", "sequence": { "length": 615, "sequence": "MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A9T0/", "id": "A2A9T0", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8820", "id": "8820", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6DG50-1", "protein_name": "TANK-binding kinase 1-binding protein 1; TBK1-binding protein 1; Protein ProSAPiP2.", "sequence": { "length": 613, "sequence": "MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLRQICGLEKQLQQQQGLRDAAFSSLSPPAVPATACPDLDLHYLALRGGPALGHAGWPGPTSVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSECGMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQRHSPLSQRHSPAPACPSPSPPARPPPCAPCQSPAAQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERAYAKPPSHHAKAGFQGRRSYSELAEGAAYAAASPAWLQAEAATLPKPRAYGGELYGPGRPLSPRRAFEGIRLRFEKQPSEEEEWAMPASPPSPEASTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A9T0/", "id": "A2A9T0", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8820", "id": "8820", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "ac": "NP_932768.2", "name": "TANK-binding kinase 1-binding protein 1 isoform 1; TANK-binding kinase 1-binding protein 1; tbkbp1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9T0", "id": "A2A9T0", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 64, "annotation": "n_glycosylation_sequon", "start_pos": 62 }, { "end_pos": 278, "annotation": "n_glycosylation_sequon", "start_pos": 276 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768.2", "id": "NP_932768.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:73174", "id": "mmu:73174", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038517", "id": "ENSMUSG00000038517", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/EEEWAVP/", "id": "EEEWAVP", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024581", "id": "IPR024581", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF12845", "id": "PF12845", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A9T0", "id": "PR_A2A9T0", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A9T0*", "id": "A2A9T0", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/73174", "id": "73174", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1920424", "id": "1920424", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A9T0", "disease": [], "mass": { "monoisotopic_mass": 67001.0, "chemical_mass": 67001.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A9T0", "name": "Tbkbp1; Sintbad; 3110043L15Rik; ProSAPiP2; SINTBAD.", "locus": { "end_pos": 97136171, "start_pos": 97151495, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038517", "id": "ENSMUSG00000038517", "database": "Ensembl Gene" } ] } } ] }