{ "uniprot_canonical_ac": "A2A974-1", "sequence": { "header": "tr|A2A974-1|A2A974_MOUSE Isoform 1 of Cytochrome P450, family 4, subfamily a, polypeptide 12B OS=Mus musculus OX=10090 GN=Cyp4a12b PE=1 SV=1 CANONICAL=A2A974-1", "length": 508, "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ" }, "uniprot_id": "A2A974_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "cytochrome P450, family 4, subfamily a family", "cytochrome P450, family 4, subfamily a, polypeptide 12" ], "uniprotkb": [ "Cytochrome P450, family 4, subfamily a, polypeptide 12B" ] }, "gene": { "refseq": [ "Cyp4a12b", "BC060945", "Cyp4a12" ], "uniprotkb": [ "Cyp4a12b", "BC060945", "Cyp4a12" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Cytochrome P450, family 4, subfamily a, polypeptide 12B." }, "publication": [ { "title": "Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17112342", "journal": "The Biochemical journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" } ], "authors": "Muller DN, Schmidt C, Barbosa-Sicard E, Wellner M, Gross V, Hercule H, Markovic M, Honeck H, Luft FC, Schunck WH", "date": "2007", "pmid": "17112342" }, { "title": "Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15313227", "journal": "Archives of biochemistry and biophysics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" } ], "authors": "Jeffery B, Choudhury AI, Horley N, Bruce M, Tomlinson SR, Roberts RA, Gray TJ, Barrett DA, Shaw PN, Kendall D, Bell DR", "date": "2004", "pmid": "15313227" }, { "title": "Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15066132", "journal": "Fundamental & clinical pharmacology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" } ], "authors": "Le Bouquin R, Lugnier A, Frossard N, Pons F", "date": "2004", "pmid": "15066132" }, { "title": "A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9271096", "journal": "The Biochemical journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" } ], "authors": "Heng YM, Kuo CS, Jones PS, Savory R, Schulz RM, Tomlinson SR, Gray TJ, Bell DR", "date": "1997", "pmid": "9271096" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A974#A2A974-1", "isoform_ac": "A2A974-1", "locus": { "end_pos": 115411683, "start_pos": 115438222, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000094887", "id": "ENSMUST00000094887", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000092487", "id": "ENSMUSP00000092487", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A974-1|A2A974_MOUSE Isoform 1 of Cytochrome P450, family 4, subfamily a, polypeptide 12B OS=Mus musculus OX=10090 GN=Cyp4a12b PE=1 SV=1 CANONICAL=A2A974-1", "length": 508, "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:13118", "resource": "KEGG Pathway", "id": "mmu:13118", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211979", "resource": "Reactome", "id": "R-MMU-211979", "name": "Eicosanoids" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142691", "resource": "Reactome", "id": "R-MMU-2142691", "name": "Synthesis of Leukotrienes (LT) and Eoxins (EX)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211935", "resource": "Reactome", "id": "R-MMU-211935", "name": "Fatty acids" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211958", "resource": "Reactome", "id": "R-MMU-211958", "name": "Miscellaneous substrates" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142816", "resource": "Reactome", "id": "R-MMU-2142816", "name": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "annotation": "'...Cyp4a12...is expressed in mouse lung... may be upregulated by...clofibrate and... cytokine IL-1Beta...IL-1Beta has been...associated with asthma...data raise the question...whether CYP4A expression could be altered in asthmatic conditions' p. 184-5", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P24464-1", "protein_name": "Cytochrome P450 4A12; 1.14.14.1; CYPIVA8; CYPIVA12; Cytochrome P450-PP1; Cytochrome P450-KP1.", "sequence": { "length": 508, "sequence": "MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134044", "id": "134044", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q91WL5-1", "protein_name": "Cytochrome P450 4A12A; 1.14.14.1; CYPIVA12.", "sequence": { "length": 508, "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134044", "id": "134044", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q5TCH4-1", "protein_name": "Cytochrome P450 4A22; Fatty acid omega-hydroxylase; CYPIVA22; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase; 1.14.14.80.", "sequence": { "length": 519, "sequence": "MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134044", "id": "134044", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "ac": "NP_758510.2", "name": "cytochrome P450, family 4, subfamily a family; cytochrome P450, family 4, subfamily a, polypeptide 12.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "heme binding", "id": "GO:0020037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "monooxygenase activity", "id": "GO:0004497" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102116", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "laurate hydroxylase activity", "id": "GO:0102116" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0103002", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "16-hydroxypalmitate dehydrogenase activity", "id": "GO:0103002" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" } ], "total": 2, "name": "Cellular Component" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211979", "id": "R-MMU-211979", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142691", "id": "R-MMU-2142691", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211935", "id": "R-MMU-211935", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211958", "id": "R-MMU-211958", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142816", "id": "R-MMU-2142816", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:13118", "id": "mmu:13118", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078597", "id": "ENSMUSG00000078597", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/LWTWRIV/", "id": "LWTWRIV", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "id": "IPR001128", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "id": "IPR002401", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "id": "IPR017972", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "id": "IPR036396", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00067", "id": "PF00067", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/13118", "id": "13118", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3611747", "id": "3611747", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A974", "disease": [], "mass": { "monoisotopic_mass": 58309.0, "chemical_mass": 58309.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "name": "Cyp4a12b; BC060945; Cyp4a12.", "locus": { "end_pos": 115439034, "start_pos": 115411624, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000078597", "id": "ENSMUSG00000078597", "database": "Ensembl Gene" } ] } } ] }