{ "uniprot_canonical_ac": "A2A8U2-1", "sequence": { "header": "sp|A2A8U2-1|TM201_MOUSE Isoform 1 of Transmembrane protein 201 OS=Mus musculus OX=10090 GN=Tmem201 PE=1 SV=1 CANONICAL=A2A8U2-1", "length": 664, "sequence": "MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHTMVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILLRALAFLACAFLLFTTLYGPSEPFTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLGLLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLRRIDAFSTCLWALLLGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRYFSGDSASLFPSSPSLAVPYPSVTSSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLSRALSLGTIPPLTRTDSGYLFSGSRPPSRVSPAGEVSLSDYFSLLSSSFPASPLPSPAPSVASSVASSSGSLRHRRPLISPARLNLKGQKLLLFSSPGEAPNTPSSSEEFSPPNGSLFIESPQLPQRNHTRDTKHTMEMRSMLARDSARSSHSIKKEDESSQSSTCVVDTTTKGCSEETTPWKARVSPSLVRGLLAVSLAVNALFTSAYLYQSLR" }, "uniprot_id": "TM201_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "transmembrane protein 201 isoform c", "spindle-associated membrane protein 1" ], "uniprotkb": [ "Transmembrane protein 201", "Spindle-associated membrane protein 1" ] }, "gene": { "refseq": [ "Tmem201", "AV028368", "D4Ertd429e", "Net5", "Samp1" ], "uniprotkb": [ "Tmem201", "D4Ertd429e", "Net5", "Samp1", "AV028368" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Transmembrane protein 201; Spindle-associated membrane protein 1." }, "publication": [ { "title": "A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28301579", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ], "authors": "Menghini P, Di Martino L, Lopetuso LR, Corridoni D, Webster JC, Xin W, Arseneau KO, Lam M, Pizarro TT, Cominelli F", "date": "2017", "pmid": "28301579" }, { "title": "Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28893537", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ], "authors": "Shimizu A, Tani H, Takibuchi G, Ishikawa K, Sakurazawa R, Inoue T, Hashimoto T, Nakada K, Takenaga K, Hayashi JI", "date": "2017", "pmid": "28893537" }, { "title": "[Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice].", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25051721", "journal": "Arkhiv patologii", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ], "authors": "Khudoerkov RM, Sal'kov VN, Sal'nikova OV, Sobolev VB", "date": "2014", "pmid": "25051721" }, { "title": "Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23583482", "journal": "Brain research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ], "authors": "Aoyama Y, Kim TY, Yoshimoto T, Niimi K, Takahashi E, Itakura C", "date": "2013", "pmid": "23583482" }, { "title": "Samp1 is a component of TAN lines and is required for nuclear movement.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22349700", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A8U2/publications", "id": "A2A8U2", "database": "UniProtKB" } ], "authors": "Borrego-Pinto J, Jegou T, Osorio DS, Aurade F, Gorjanacz M, Koch B, Mattaj IW, Gomes ER", "date": "2012", "pmid": "22349700" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2#A2A8U2-1", "isoform_ac": "A2A8U2-1", "locus": { "end_pos": 149716983, "start_pos": 149737947, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105687", "id": "ENSMUST00000105687", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101312", "id": "ENSMUSP00000101312", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A8U2-1|TM201_MOUSE Isoform 1 of Transmembrane protein 201 OS=Mus musculus OX=10090 GN=Tmem201 PE=1 SV=1 CANONICAL=A2A8U2-1", "length": 664, "sequence": "MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHTMVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILLRALAFLACAFLLFTTLYGPSEPFTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLGLLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLRRIDAFSTCLWALLLGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRYFSGDSASLFPSSPSLAVPYPSVTSSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLSRALSLGTIPPLTRTDSGYLFSGSRPPSRVSPAGEVSLSDYFSLLSSSFPASPLPSPAPSVASSVASSSGSLRHRRPLISPARLNLKGQKLLLFSSPGEAPNTPSSSEEFSPPNGSLFIESPQLPQRNHTRDTKHTMEMRSMLARDSARSSHSIKKEDESSQSSTCVVDTTTKGCSEETTPWKARVSPSLVRGLLAVSLAVNALFTSAYLYQSLR" } }, { "url": "https://www.uniprot.org/uniprot/A2A8U2#A2A8U2-2", "isoform_ac": "A2A8U2-2", "locus": { "end_pos": 149727211, "start_pos": 149737947, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000103208", "id": "ENSMUST00000103208", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000099497", "id": "ENSMUSP00000099497", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A8U2-2|TM201_MOUSE Isoform 2 of Transmembrane protein 201 OS=Mus musculus OX=10090 GN=Tmem201 PE=1 SV=1 CANONICAL=A2A8U2-1", "length": 392, "sequence": "MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHTMVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILLRALAFLACAFLLFTTLYGPSEPFTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLGLLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLRRIDAFSTCLWALLLGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRSEKQQ" } }, { "url": "https://www.uniprot.org/uniprot/A2A8U2#A2A8U2-3", "isoform_ac": "A2A8U2-3", "locus": { "end_pos": 149718015, "start_pos": 149737947, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000054459", "id": "ENSMUST00000054459", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000050481", "id": "ENSMUSP00000050481", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A8U2-3|TM201_MOUSE Isoform 3 of Transmembrane protein 201 OS=Mus musculus OX=10090 GN=Tmem201 PE=1 SV=1 CANONICAL=A2A8U2-1", "length": 634, "sequence": "MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHTMVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILLRALAFLACAFLLFTTLYGPSEPFTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLGLLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLRRIDAFSTCLWALLLGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRYFSGDSASLFPSSPSLAVPYPSVTSSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLSRALSLGTIPPLTRTDSGYLFSGSRPPSRVSPAGEVSLSDYFSLLSSSFPASPLPSPAPSVASSVASSSGSLRHRRPLISPARLNLKGQKLLLFSSPGEAPNTPSSSEEFSPPNGSLFIESPQLPQRNHTRDTKHTMEMRSMLARDSARSSHSIKKEDESSQSSTCVVDTTTKGCSEETTPWKGL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:230917", "resource": "KEGG Pathway", "id": "mmu:230917", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2#function", "annotation": "Isoform 3: Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2#function", "id": "A2A8U2", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A8U2#function", "annotation": "Involved in nuclear movement during fibroblast polarization and migration (PubMed:22349700). May recruit Ran GTPase to the nuclear periphery (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2#function", "id": "A2A8U2", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A8U2#function", "annotation": "Isoform 2: May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2#function", "id": "A2A8U2", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "annotation": "These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "annotation": "Data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "annotation": "In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "annotation": "At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "annotation": "Findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration GeneRIF: Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5SNT2-1", "protein_name": "Transmembrane protein 201; Spindle-associated membrane protein 1.", "sequence": { "length": 666, "sequence": "MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTMVNCWFCNQDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSSAPSLRDPSQPQQWVSSQVLLCKRCNHHQTTKIKQLAAFAPREEGRYDEEVEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFKRREADQTHAQNFSSAVKSPVQVILLRALAFLACAFLLTTALYGASGHFAPGTTVPLALPPGGNGSATPDNGTTPGAEGWRQLLGLLPEHMAEKLCEAWAFGQSHQTGVVALGLLTCLLAMLLAGRIRLRRIDAFCTCLWALLLGLHLAEQHLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRFFPGDSAGLFPTSPSLAIPHPSVGGSPASLFIPSPPSFLPLANQQLFRSPRRTSPSSLPGRLSRALSLGTIPSLTRADSGYLFSGSRPPSQVSRSGEFPVSDYFSLLSGSCPSSPLPSPAPSVAGSVASSSGSLRHRRPLISPARLNLKGQKLLLFPSPPGEAPTTPSSSDEHSPHNGSLFTMEPPHVPRKPPLQDVKHALDLRSKLERGSACSNRSIKKEDDSSQSSTCVVDTTTRGCSEEAATWRGRFGPSLVRGLLAVSLAANALFTSVFLYQSLR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/35319", "id": "35319", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "ac": "NP_001271199.1", "name": "transmembrane protein 201 isoform c; spindle-associated membrane protein 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "actin filament binding", "id": "GO:0051015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005521", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "lamin binding", "id": "GO:0005521" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "nuclear membrane", "id": "GO:0031965" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "nuclear envelope", "id": "GO:0005635" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005639", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "integral component of nuclear inner membrane", "id": "GO:0005639" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010761", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "fibroblast migration", "id": "GO:0010761" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007097", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "nuclear migration", "id": "GO:0007097" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030473", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "nuclear migration along microtubule", "id": "GO:0030473" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090435", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "protein localization to nuclear envelope", "id": "GO:0090435" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006998", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "nuclear envelope organization", "id": "GO:0006998" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051642", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "id": "A2A8U2", "database": "UniProtKB" } ], "name": "centrosome localization", "id": "GO:0051642" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 258, "annotation": "n_glycosylation_sequon", "start_pos": 256 }, { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 }, { "end_pos": 565, "annotation": "n_glycosylation_sequon", "start_pos": 563 }, { "end_pos": 579, "annotation": "n_glycosylation_sequon", "start_pos": 577 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199.1", "id": "NP_001271199.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:230917", "id": "mmu:230917", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000044700", "id": "ENSMUSG00000044700", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/QSHQMGV/", "id": "QSHQMGV", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018617", "id": "IPR018617", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018861", "id": "IPR018861", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040041", "id": "IPR040041", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF09779", "id": "PF09779", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF10476", "id": "PF10476", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28646", "id": "PTHR28646", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A8U2", "id": "PR_A2A8U2", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A8U2*", "id": "A2A8U2", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/230917", "id": "230917", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1196277", "id": "1196277", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A8U2", "disease": [], "mass": { "monoisotopic_mass": 72500.0, "chemical_mass": 72500.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A8U2", "name": "Tmem201; D4Ertd429e; Net5; Samp1; AV028368.", "locus": { "end_pos": 149715375, "start_pos": 149738044, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000044700", "id": "ENSMUSG00000044700", "database": "Ensembl Gene" } ] } } ] }