{ "uniprot_canonical_ac": "A2A8L1-1", "sequence": { "header": "sp|A2A8L1-1|CHD5_MOUSE Isoform 1 of Chromodomain-helicase-DNA-binding protein 5 OS=Mus musculus OX=10090 GN=Chd5 PE=1 SV=1 CANONICAL=A2A8L1-1", "length": 1946, "sequence": "MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDPKTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQTSSRRRDFPLFQRSFPAEPSHLPNPRGREKLQPF" }, "uniprot_id": "CHD5_MOUSE", "enzyme_annotation": [ { "ec": "3.6.4.12", "activity": "ATP + H(2)O = ADP + phosphate." }, { "ec": "3.6.4.12", "activity": "" } ], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Chromodomain-helicase-DNA-binding protein 5", "CHD-5", "3.6.4.12", "ATP-dependent helicase CHD5" ] }, "gene": { "refseq": [], "uniprotkb": [ "Chd5", "Kiaa0444" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Chromodomain-helicase-DNA-binding protein 5; CHD-5; 3.6.4.12; ATP-dependent helicase CHD5.", "short": "CHD-5" }, "publication": [ { "title": "CHD5 is required for spermiogenesis and chromatin condensation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24252660", "journal": "Mech. Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1/publications", "id": "A2A8L1", "database": "UniProtKB" } ], "authors": "Brodeur G.M., Hess R.A., Higashi M., Kolla V., Raabe T.D., Zhuang T.", "date": "2014", "pmid": "24252660" }, { "title": "Chd5 requires PHD-mediated histone 3 binding for tumor suppression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23318260", "journal": "Cell Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1/publications", "id": "A2A8L1", "database": "UniProtKB" } ], "authors": "Kuo A., McCombie W.R., Paul S., Joshua-Tor L., Vogel H., Mills A.A., Gozani O., Hammell M., Schalch T.", "date": "2013", "pmid": "23318260" }, { "title": "CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23948251", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1/publications", "id": "A2A8L1", "database": "UniProtKB" } ], "authors": "Turner S., Helin K., Bracken A.P., Streubel G., Chadderton N., Dolan M.J., Egan C.M., Farrar G.J., Hansen K., Holmberg J., Nyman U., O'Connell D.J., Rraklli V., Skotte J.", "date": "2013", "pmid": "23948251" }, { "title": "CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21931736", "journal": "PLoS ONE", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1/publications", "id": "A2A8L1", "database": "UniProtKB" } ], "authors": "Zhang P., Zhang Y., Becker K.G., Mattson M.P., Mughal M.R., Pazin M.J., Potts R.C., Precht P., Wood W.H., Wurster A.L.", "date": "2011", "pmid": "21931736" }, { "title": "CHD5 is a tumor suppressor at human 1p36.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17289567", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1/publications", "id": "A2A8L1", "database": "UniProtKB" } ], "authors": "Wu Y., Vogel H., Bagchi A., Bredel M., Brodt M., Capurso D., Francis D., Mills A.A., Papazoglu C.", "date": "2007", "pmid": "17289567" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1#A2A8L1-1", "isoform_ac": "A2A8L1-1", "locus": { "end_pos": 152338952, "start_pos": 152386962, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000005175", "id": "ENSMUST00000005175", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000005175", "id": "ENSMUSP00000005175", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A8L1-1|CHD5_MOUSE Isoform 1 of Chromodomain-helicase-DNA-binding protein 5 OS=Mus musculus OX=10090 GN=Chd5 PE=1 SV=1 CANONICAL=A2A8L1-1", "length": 1946, "sequence": "MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDPKTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQTSSRRRDFPLFQRSFPAEPSHLPNPRGREKLQPF" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L1#E9PYL1-1", "isoform_ac": "E9PYL1-1", "locus": { "end_pos": 152338952, "start_pos": 152385953, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000030775", "id": "ENSMUST00000030775", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000030775", "id": "ENSMUSP00000030775", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PYL1-1|CHD5_MOUSE Computationally mapped isoform of Chromodomain-helicase-DNA-binding protein 5 OS=Mus musculus OX=10090 GN=Chd5 PE=1 SV=1 CANONICAL=A2A8L1-1", "length": 1952, "sequence": "MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDPKTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSSQMYNNSFGPNFRGPGPGGIVNYNQMPLGPYVTDI" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L1#E9PYU4-1", "isoform_ac": "E9PYU4-1", "locus": { "end_pos": 152338952, "start_pos": 152385953, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000164662", "id": "ENSMUST00000164662", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000132600", "id": "ENSMUSP00000132600", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PYU4-1|CHD5_MOUSE Computationally mapped isoform of Chromodomain-helicase-DNA-binding protein 5 OS=Mus musculus OX=10090 GN=Chd5 PE=1 SV=1 CANONICAL=A2A8L1-1", "length": 1915, "sequence": "MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDPKTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSSQMYNNSFGPNFRGPGPGGIVNYNQMPLGPYVTDI" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1#function", "annotation": "Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1#function", "id": "A2A8L1", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8TDI0-1", "protein_name": "Chromodomain-helicase-DNA-binding protein 5; CHD-5; 3.6.4.12; ATP-dependent helicase CHD5.", "sequence": { "length": 1954, "sequence": "MRGPVGTEEELPRLFAEEMENEDEMSEEEDGGLEAFDDFFPVEPVSLPKKKKPKKLKENKCKGKRKKKEGSNDELSENEEDLEEKSESEGSDYSPNKKKKKKLKDKKEKKAKRKKKDEDEDDNDDGCLKEPKSSGQLMAEWGLDDVDYLFSEEDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTISPPLAVSPPQVPQPVPIRKAKTKEGKGPGVRKKIKGSKDGKKKGKGKKTAGLKFRFGGISNKRKKGSSSEEDEREESDFDSASIHSASVRSECSAALGKKSKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPDVEPSLPPPKPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMIHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEIDDIDIPYYDNLKQAYWGHRELMLGEDTRLPKRLLKKGKKLRDDKQEKPPDTPIVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPVTPIPDVQSSKGGNLAASAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREIIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLIPEGPEGKKSGEVISSDPNTPVPASPAHLLPAPLGLPDKMEAQLGYMDEKDPGAQKPRQPLEVQALPAALDRVESEDKHESPASKERAREERPEETEKAPPSPEQLPREEVLPEKEKILDKLELSLIHSRGDSSELRPDDTKAEEKEPIETQQNGDKEEDDEGKKEDKKGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYDIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEVHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSSQMYSNNFGPNFRGPGPGGIVNYNQMPLGPYVTDI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/56712", "id": "56712", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "histone deacetylase binding", "id": "GO:0042826" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061628", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "H3K27me3 modified histone binding", "id": "GO:0061628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "DNA helicase activity", "id": "GO:0003678" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "heterochromatin", "id": "GO:0000792" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016581", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "NuRD complex", "id": "GO:0016581" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "nuclear speck", "id": "GO:0016607" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043967", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "histone H4 acetylation", "id": "GO:0043967" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045595", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "regulation of cell differentiation", "id": "GO:0045595" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901798", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "positive regulation of signal transduction by p53 class mediator", "id": "GO:1901798" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021895", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "cerebral cortex neuron differentiation", "id": "GO:0021895" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035093", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "spermatogenesis, exchange of chromosomal proteins", "id": "GO:0035093" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060850", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "regulation of transcription involved in cell fate commitment", "id": "GO:0060850" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "transcription by RNA polymerase II", "id": "GO:0006366" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098532", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "id": "A2A8L1", "database": "UniProtKB" } ], "name": "histone H3-K27 trimethylation", "id": "GO:0098532" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 307, "annotation": "n_glycosylation_sequon", "start_pos": 305 }, { "end_pos": 603, "annotation": "n_glycosylation_sequon", "start_pos": 601 }, { "end_pos": 859, "annotation": "n_glycosylation_sequon", "start_pos": 857 }, { "end_pos": 1015, "annotation": "n_glycosylation_sequon", "start_pos": 1013 }, { "end_pos": 1372, "annotation": "n_glycosylation_sequon", "start_pos": 1370 }, { "end_pos": 1813, "annotation": "n_glycosylation_sequon", "start_pos": 1811 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006538995.1", "id": "XP_006538995.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000005045", "id": "ENSMUSG00000005045", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "id": "IPR001965", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "id": "IPR011011", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "id": "IPR019786", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "id": "IPR019787", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953", "id": "IPR000953", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "id": "IPR016197", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000330", "id": "IPR000330", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "id": "IPR001650", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "id": "IPR014001", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002464", "id": "IPR002464", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028727", "id": "IPR028727", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023780", "id": "IPR023780", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009462", "id": "IPR009462", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009463", "id": "IPR009463", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012957", "id": "IPR012957", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012958", "id": "IPR012958", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038718", "id": "IPR038718", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00628", "id": "PF00628", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00176", "id": "PF00176", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00271", "id": "PF00271", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00385", "id": "PF00385", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06461", "id": "PF06461", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06465", "id": "PF06465", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08073", "id": "PF08073", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08074", "id": "PF08074", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45623:SF6", "id": "PTHR45623:SF6", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A8L1", "id": "PR_A2A8L1", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A8L1*", "id": "A2A8L1", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/269610", "id": "269610", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3036258", "id": "3036258", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A8L1", "disease": [], "mass": { "monoisotopic_mass": 222515.0, "chemical_mass": 222515.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A8L1", "name": "Chd5; Kiaa0444.", "locus": { "end_pos": 152390194, "start_pos": 152338651, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000005045", "id": "ENSMUSG00000005045", "database": "Ensembl Gene" } ] } } ] }