{ "uniprot_canonical_ac": "A2A884-1", "sequence": { "header": "sp|A2A884-1|ZEP3_MOUSE Isoform 1 of Transcription factor HIVEP3 OS=Mus musculus OX=10090 GN=Hivep3 PE=1 SV=1 CANONICAL=A2A884-1", "length": 2348, "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASILPPEELPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAASGPSTDVLPKPKHPLLSSSLYSSGSHGSSQERCSLSQSSTGPSLEDPAPFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQITKAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAHNRPLGSTKSPAEASKSAPSLEGPTSFQPRTPKPGAGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLAVPAAPPPPAAPPERRKCFLVRQASLNRPPEAELEAVPKGKQESSEEPAASKPSTKSSVPQISVGTTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPASTALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSSKAHRRGLPPMSVKKEDPKEQTDLPPLAPPSSLPLSDTSPKPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPESQKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLHQDSEGQEGAEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEESQDELSGPCSEAAPPCLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDMSSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGRDLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWALAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHRAEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPHTLANLKASSFPPLDRSSSMDCLAETSTYSPPRSRNLSGEPRTRQGSPELLGRGELRTPLFLPKGSGPPSI" }, "uniprot_id": "ZEP3_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "transcription factor HIVEP3", "recombinant component; kappa-binding protein 1; zinc finger protein ZAS3; KB-binding and regognition component; kappa-B and V(D)J recombination signal sequences-binding protein; human immunodeficiency virus type I enhancer-binding protein 3 homolog; kappa B and Rss recognition component; KB-binding and recognition component" ], "uniprotkb": [ "Transcription factor HIVEP3", "Kappa-binding protein 1", "KBP-1", "Schnurri-3", "KB-binding and recognition component", "Kappa-B and V(D)J recombination signal sequences-binding protein", "Zinc finger protein ZAS3", "Recombinant component", "Human immunodeficiency virus type I enhancer-binding protein 3 homolog" ] }, "gene": { "refseq": [ "Hivep3", "2900056N03Rik", "A130075N07", "AI848000", "E030045D18Rik", "KBP-1", "KBP1", "Krc", "Rc", "Schnurri-3", "Shn3", "Zas3" ], "uniprotkb": [ "Hivep3", "KBP1", "Kiaa1555", "Krc", "Rc", "Zas3", "shn3", "2900056N03Rik", "A130075N07", "AI848000", "E030045D18Rik", "KBP-1", "Schnurri-3", "Shn3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Transcription factor HIVEP3; Kappa-binding protein 1; KBP-1; Schnurri-3; KB-binding and recognition component; Kappa-B and V(D)J recombination signal sequences-binding protein; Zinc finger protein ZAS3; Recombinant component; Human immunodeficiency virus type I enhancer-binding protein 3 homolog." }, "publication": [ { "title": "Targeting skeletal endothelium to ameliorate bone loss.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29785024", "journal": "Nature medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ], "authors": "Xu R, Yallowitz A, Qin A, Wu Z, Shin DY, Kim JM, Debnath S, Ji G, Bostrom MP, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos MG, Wach A, Zhang Y, Inoue K, Di Lorenzo A, Zhao B, Butler JM, Shim JH, Glimcher LH, Greenblatt MB", "date": "2018", "pmid": "29785024" }, { "title": "Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26091038", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ], "authors": "Wei J, Shimazu J, Makinistoglu MP, Maurizi A, Kajimura D, Zong H, Takarada T, Lezaki T, Pessin JE, Hinoi E, Karsenty G", "date": "2015", "pmid": "26091038" }, { "title": "Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24563464", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ], "authors": "Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S", "date": "2014", "pmid": "24563464" }, { "title": "Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23945236", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ], "authors": "Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC", "date": "2013", "pmid": "23945236" }, { "title": "Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16728642", "journal": "Science", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Glimcher L.H., Jones D.C., Oukka M., Wein M.N., Glimcher M.J., Hofstaetter J.G.", "date": "2006", "pmid": "16728642" }, { "title": "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15627499", "journal": "Biochim. Biophys. Acta", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Wu L.-C., Hong J.-W.", "date": "2005", "pmid": "15627499" }, { "title": "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14707112", "journal": "J. Exp. Med.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Glimcher L.H., Oukka M., Wein M.N.", "date": "2004", "pmid": "14707112" }, { "title": "Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14530385", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Hong J.W., Wu L.-C., Allen C.E.", "date": "2003", "pmid": "14530385" }, { "title": "Embryonic expression and regulation of the large zinc finger protein KRC.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12001065", "journal": "Genesis", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Wu L.-C., Robinson M.L., Hicar M.D.", "date": "2002", "pmid": "12001065" }, { "title": "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11804591", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH", "date": "2002", "pmid": "11804591" }, { "title": "The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12193271", "journal": "BMC Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Wu L.-C., Allen C.E., Mak C.-H.", "date": "2002", "pmid": "12193271" }, { "title": "The kappaB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10625627", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Hjelmsoe I, Allen CE, Cohn MA, Tulchinsky EM, Wu LC", "date": "2000", "pmid": "10625627" }, { "title": "Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11035930", "journal": "Exp. Cell Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Wu L.-C., Allen C.E.", "date": "2000", "pmid": "11035930" }, { "title": "Regulation by phosphorylation of the zinc finger protein KRC that binds the kappaB motif and V(D)J recombination signal sequences.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9862992", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Yu C.Y., Wu L.-C., Bachmeyer C., Mak C.H.", "date": "1999", "pmid": "9862992" }, { "title": "The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8812474", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Wu LC, Liu Y, Strandtmann J, Mak CH, Lee B, Li Z, Yu CY", "date": "1996", "pmid": "8812474" }, { "title": "Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8255760", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A884/publications", "id": "A2A884", "database": "UniProtKB" } ], "authors": "Wu LC, Mak CH, Dear N, Boehm T, Foroni L, Rabbitts TH", "date": "1993", "pmid": "8255760" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A884#A2A884-1", "isoform_ac": "A2A884-1", "locus": { "end_pos": 120094489, "start_pos": 120134348, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106307", "id": "ENSMUST00000106307", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101914", "id": "ENSMUSP00000101914", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A884-1|ZEP3_MOUSE Isoform 1 of Transcription factor HIVEP3 OS=Mus musculus OX=10090 GN=Hivep3 PE=1 SV=1 CANONICAL=A2A884-1", "length": 2348, "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASILPPEELPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAASGPSTDVLPKPKHPLLSSSLYSSGSHGSSQERCSLSQSSTGPSLEDPAPFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQITKAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAHNRPLGSTKSPAEASKSAPSLEGPTSFQPRTPKPGAGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLAVPAAPPPPAAPPERRKCFLVRQASLNRPPEAELEAVPKGKQESSEEPAASKPSTKSSVPQISVGTTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPASTALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSSKAHRRGLPPMSVKKEDPKEQTDLPPLAPPSSLPLSDTSPKPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPESQKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLHQDSEGQEGAEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEESQDELSGPCSEAAPPCLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDMSSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGRDLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWALAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHRAEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPHTLANLKASSFPPLDRSSSMDCLAETSTYSPPRSRNLSGEPRTRQGSPELLGRGELRTPLFLPKGSGPPSI" } }, { "url": "https://www.uniprot.org/uniprot/A2A884#F7D7H6-1", "isoform_ac": "F7D7H6-1", "locus": { "end_pos": 119733797, "start_pos": 119734144, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000084306", "id": "ENSMUST00000084306", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000081330", "id": "ENSMUSP00000081330", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7D7H6-1|ZEP3_MOUSE Computationally mapped isoform of Transcription factor HIVEP3 OS=Mus musculus OX=10090 GN=Hivep3 PE=1 SV=1 CANONICAL=A2A884-1", "length": 116, "sequence": "VGARRRGCSHAGPLEQPQRSAQVRPPRRSANASLGTSCPRPRAVSAPHRPGGGPVAYPPPRRPADPDCPPIRRDAGLGARVPHLSPCCTRGQISETRRNPGRGKFVDIGAPRGAGS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:16656", "resource": "KEGG Pathway", "id": "mmu:16656", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A884#function", "annotation": "Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884#function", "id": "A2A884", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "annotation": "Thus, Alg2, as a downstream mediator of Hivep3, suppresses osteogenesis, whereas it promotes chondrogenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "annotation": "Knockdown of Shn3 in adult mice results in a high-bone mass phenotype.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "annotation": "KRC overexpression inhibits while antisense or dominant-negative KRC enhances NFkappaB-dependent transactivation and JNK phosphorylation and consequently, apoptosis and cytokine gene expression", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZRB5-1", "protein_name": "Human immunodeficiency virus type I enhancer-binding protein 3; Immunodeficiency virus type I enhancer binding protein 3 (Predicted).", "sequence": { "length": 2350, "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSTPYPGSSTTASSEGASQELLAPQPFSGPSVALREGAQEKTGQQQKPPRRPSIEASAHIPKLPQHPLTPAFMSPSKPEHLLEGSTWQLVDPTRPGPSGSFVAPGLHPQSQLLPSHASILPPEDLPGIPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGATSGPSTDVLPKSKHPLLSSSLYSSGSHGSSQERCSQSSTAPSLEDPTPFAEASSEHPLSHKLEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSAEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRESLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHIADPEVPSRSTPVFTSHPRMLKRQPAIELPLGAEYSSEEPGPSSKDPITKPSDEPEPKESDLTKKTKKGLKTKGVNYECTICGARYKKRDNYEAHKKYYCSELQITKAHPAGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPGFSSPGPSDAAHNLPLESTKSPAEASKSVPTLEGPTSFQPRTPKPGSGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPGSLEEDKPLAPFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAETPGPLSDTRSKTLGTHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSVAVPAAPPPPAAPPERRKCFLVRQASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPVSLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSASPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSSTSMALTKYEEPSSKSMTVCGADVYEAEPGPSSISKEQSRGFQTPYLRVPERKGTALSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCNVVLTSTEDRKKTEKPHVGSQGRSRRETETLSCLSSDVSDPKELSPLSQSTLSHGTAPGSEALKEYAQPSSKAHRRCLPPLSVKKEDPKEQTDLPPLAPPSSLPLSDTSPRPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSMVSLESQKDPARVEKEEKAEEGTPTSKRGEPTRVKIFEGGYKSNEEYIYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCRHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLLQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEEESQDELSRPSSEAAPLCLPATLQEDSSLIRGPQPPDATSDAAPRGSSISEATRLTASSCSTPSQGTQGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKTDSSPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPELSCLTPYPIGREVPAGLESATVTGTPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDKYGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWKTESRSPSAGPAPLSSRPSSAPHDFHGHLPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMGTHSPCPPQLPQGHPLAPSWRGLLESPHALANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNLSGEPRTRPDSPELLGSGELRTPLFLSKDSGPPSI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A884/", "id": "A2A884", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/7803", "id": "7803", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5T1R4-1", "protein_name": "Transcription factor HIVEP3; Kappa-binding protein 1; KBP-1; Kappa-B and V(D)J recombination signal sequences-binding protein; Zinc finger protein ZAS3; Human immunodeficiency virus type I enhancer-binding protein 3.", "sequence": { "length": 2406, "sequence": "MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGPQPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSALSYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVDPGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSPGQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCASPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASARFPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A884/", "id": "A2A884", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/7803", "id": "7803", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "ac": "NP_034787.2", "name": "transcription factor HIVEP3; recombinant component; kappa-binding protein 1; zinc finger protein ZAS3; KB-binding and regognition component; kappa-B and V(D)J recombination signal sequences-binding protein; human immunodeficiency virus type I enhancer-binding protein 3 homolog; kappa B and Rss recognition component; KB-binding and recognition component.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035914", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884", "database": "UniProtKB" } ], "name": "skeletal muscle cell differentiation", "id": "GO:0035914" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 1572, "annotation": "n_glycosylation_sequon", "start_pos": 1570 }, { "end_pos": 1764, "annotation": "n_glycosylation_sequon", "start_pos": 1762 }, { "end_pos": 1863, "annotation": "n_glycosylation_sequon", "start_pos": 1861 }, { "end_pos": 1955, "annotation": "n_glycosylation_sequon", "start_pos": 1953 }, { "end_pos": 2315, "annotation": "n_glycosylation_sequon", "start_pos": 2313 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787.2", "id": "NP_034787.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:16656", "id": "mmu:16656", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028634", "id": "ENSMUSG00000028634", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/AQLPLHE/", "id": "AQLPLHE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034729", "id": "IPR034729", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A884", "id": "PR_A2A884", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/16656", "id": "16656", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:106589", "id": "106589", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A884", "disease": [], "mass": { "monoisotopic_mass": 253413.0, "chemical_mass": 253413.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A884", "name": "Hivep3; KBP1; Kiaa1555; Krc; Rc; Zas3; shn3; 2900056N03Rik; A130075N07; AI848000; E030045D18Rik; KBP-1; Schnurri-3; Shn3.", "locus": { "end_pos": 120138045, "start_pos": 119733784, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000028634", "id": "ENSMUSG00000028634", "database": "Ensembl Gene" } ] } } ] }