{ "uniprot_canonical_ac": "A2A761-1", "sequence": { "header": "sp|A2A761-1|ZFP69_MOUSE Isoform 1 of Zinc finger protein 69 OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1", "length": 587, "sequence": "MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL" }, "uniprot_id": "ZFP69_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "zinc finger protein 69", "Zfp63p; zinc finger protein 642" ], "uniprotkb": [ "Zinc finger protein 69", "Zinc finger protein 642" ] }, "gene": { "refseq": [ "Zfp69", "Gm1029", "Krab2", "Zfp63" ], "uniprotkb": [ "Zfp69", "Znf642", "Gm1029", "Krab2", "Zfp63" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Zinc finger protein 69; Zinc finger protein 642." }, "publication": [ { "title": "The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26232096", "journal": "Diabetologia", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A761/publications", "id": "A2A761", "database": "UniProtKB" } ], "authors": "Chung B, Stadion M, Schulz N, Jain D, Scherneck S, Joost HG, Schurmann A", "date": "2015", "pmid": "26232096" }, { "title": "Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23641944", "journal": "BMC genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Suto J, Satou K", "date": "2013", "pmid": "23641944" }, { "title": "Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20865372", "journal": "Results and problems in cell differentiation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Scherneck S, Vogel H, Nestler M, Kluge R, Schurmann A, Joost HG", "date": "2010", "pmid": "20865372" }, { "title": "Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19578398", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A761/publications", "id": "A2A761", "database": "UniProtKB" } ], "authors": "Scherneck S, Nestler M, Vogel H, Bluher M, Block MD, Berriel Diaz M, Herzig S, Schulz N, Teichert M, Tischer S, Al-Hasani H, Kluge R, Schurmann A, Joost HG", "date": "2009", "pmid": "19578398" }, { "title": "Identification of novel oocyte and granulosa cell markers.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19539053", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Malcuit C, Trask MC, Santiago L, Beaudoin E, Tremblay KD, Mager J", "date": "2009", "pmid": "19539053" }, { "title": "Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8662221", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Marine JC, Gilbert DJ, Bellefroid EJ, Martial JA, Ihle JN, Copeland NG, Jenkins NA", "date": "1996", "pmid": "8662221" }, { "title": "Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/7479878", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Bellefroid EJ, Marine JC, Matera AG, Bourguignon C, Desai T, Healy KC, Bray-Ward P, Martial JA, Ihle JN, Ward DC", "date": "1995", "pmid": "7479878" }, { "title": "Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/2542606", "journal": "Journal of virology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Ihle JN, Smith-White B, Sisson B, Parker D, Blair DG, Schultz A, Kozak C, Lunsford RD, Askew D, Weinstein Y, et al.", "date": "1989", "pmid": "2542606" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A761#A2A761-1", "isoform_ac": "A2A761-1", "locus": { "end_pos": 120930356, "start_pos": 120949434, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106281", "id": "ENSMUST00000106281", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101888", "id": "ENSMUSP00000101888", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A761-1|ZFP69_MOUSE Isoform 1 of Zinc finger protein 69 OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1", "length": 587, "sequence": "MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL" } }, { "url": "https://www.uniprot.org/uniprot/A2A761#G3UWJ2-1", "isoform_ac": "G3UWJ2-1", "locus": { "end_pos": 120931307, "start_pos": 120935100, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000130702", "id": "ENSMUST00000130702", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000133312", "id": "ENSMUSP00000133312", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3UWJ2-1|ZFP69_MOUSE Computationally mapped isoform of Zinc finger protein 69 OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1", "length": 110, "sequence": "MLENYRNLVSVGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:381549", "resource": "KEGG Pathway", "id": "mmu:381549", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "resource": "Reactome", "id": "R-MMU-212436", "name": "Generic Transcription Pathway" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A761#function", "annotation": "Putative transcription factor that appears to regulate lipid metabolism.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761#function", "id": "A2A761", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "annotation": "Zfp69 mediates hyperlipidaemia, liver fat accumulation and mild insulin resistance. However, it does not induce type 2 diabetes, suggesting that the diabetogenic effect of the Zfp69 locus requires synergy with other as yet unidentified genes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "annotation": "Zfp69 mRNA-expression was significantly higher in diabetic subjects than in unaffected controls. Review article", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "annotation": "Zfp69 is the most likely candidate for the diabetogenic effect of Nidd/SJL locus.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q49AA0-1", "protein_name": "Zinc finger protein 69 homolog; Zinc finger protein 642.", "sequence": { "length": 526, "sequence": "MPQQLLITLPTEASTWVKLQHPKKAVEGAPLWEDVTKMFEGEALLSQDAEDVKTQRESLEDEVTPGLPTAESQELLTFKDISIDFTQEEWGQLAPAHQNLYREVMLENYSNLVSVGYQLSKPSVISQLEKGEEPWMAEKEGPGDPSSDLKSKIETIESTAKSTISQERLYHGIMMESFMRDDIIYSTLRKVSTYDDVLERHQETCMRDVRQAILTHKKRVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSYIRTKTYECNICEKIFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLSTHQRIHTGEKPFECEECGKAFRHRSSLNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHSGEKPFTCNECGKTFRQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNSSLSRHHEIHRRNAFRNKV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/45693", "id": "45693", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "ac": "NP_001005788.2", "name": "zinc finger protein 69; Zfp63p; zinc finger protein 642.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019216", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "regulation of lipid metabolic process", "id": "GO:0019216" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "lipid metabolic process", "id": "GO:0006629" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 44, "annotation": "n_glycosylation_sequon", "start_pos": 42 }, { "end_pos": 422, "annotation": "n_glycosylation_sequon", "start_pos": 420 }, { "end_pos": 562, "annotation": "n_glycosylation_sequon", "start_pos": 560 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "id": "R-MMU-212436", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:381549", "id": "mmu:381549", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000064141", "id": "ENSMUSG00000064141", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/IHVRCVH/", "id": "IHVRCVH", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "id": "cd07765", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "id": "IPR001909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "id": "IPR036051", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01352", "id": "PF01352", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/381549", "id": "381549", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:107794", "id": "107794", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A761", "disease": [], "mass": { "monoisotopic_mass": 65725.0, "chemical_mass": 65725.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "name": "Zfp69; Znf642; Gm1029; Krab2; Zfp63.", "locus": { "end_pos": 120930137, "start_pos": 120951699, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000064141", "id": "ENSMUSG00000064141", "database": "Ensembl Gene" } ] } } ] }