{ "uniprot_canonical_ac": "A2A6M5-1", "sequence": { "header": "sp|A2A6M5-1|CACO2_MOUSE Isoform 1 of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 331, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR" }, "uniprot_id": "CACO2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "calcium-binding and coiled-coil domain-containing protein 2", "nuclear domain 10 protein 52 like 1; nuclear domain 10 protein NDP52" ], "uniprotkb": [ "Calcium-binding and coiled-coil domain-containing protein 2", "Nuclear domain 10 protein NDP52", "Nuclear domain 10 protein 52" ] }, "gene": { "refseq": [ "Calcoco2", "2410154J16Rik", "C77254", "Ndp52", "Ndp52l1" ], "uniprotkb": [ "Calcoco2", "Ndp52", "Ndp52l1", "2410154J16Rik", "C77254" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Calcium-binding and coiled-coil domain-containing protein 2; Nuclear domain 10 protein NDP52; Nuclear domain 10 protein 52." }, "publication": [ { "title": "NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25450380", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" } ], "authors": "Kim S, Lee D, Song JC, Cho SJ, Yun SM, Koh YH, Song J, Johnson GV, Jo C", "date": "2014", "pmid": "25450380" }, { "title": "Functional interaction of nuclear domain 10 and its components with cytomegalovirus after infections: cross-species host cells versus native cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21552525", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" } ], "authors": "Cosme RC, Martinez FP, Tang Q", "date": "2011", "pmid": "21552525" }, { "title": "H2B homology region of major immediate-early protein 1 is essential for murine cytomegalovirus to disrupt nuclear domain 10, but is not important for viral replication in cell culture.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21632568", "journal": "The Journal of general virology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" } ], "authors": "Cosme-Cruz R, Martinez FP, Perez KJ, Tang Q", "date": "2011", "pmid": "21632568" }, { "title": "Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12620990", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5/publications", "id": "A2A6M5", "database": "UniProtKB" } ], "authors": "Page D.C., Skaletsky H., Jaenisch R., Akutsu H., Berry D.L., Bortvin A., Eggan K., Yanagimachi R.", "date": "2003", "pmid": "12620990" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5#A2A6M5-1", "isoform_ac": "A2A6M5-1", "locus": { "end_pos": 96099917, "start_pos": 96107595, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000068686", "id": "ENSMUST00000068686", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000087407", "id": "ENSMUSP00000087407", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A6M5-1|CACO2_MOUSE Isoform 1 of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 331, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR" } }, { "url": "https://www.uniprot.org/uniprot/A2A6M5#G8JL78-1", "isoform_ac": "G8JL78-1", "locus": { "end_pos": 96099917, "start_pos": 96107595, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000097162", "id": "ENSMUST00000097162", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103309", "id": "ENSMUSP00000103309", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G8JL78-1|CACO2_MOUSE Computationally mapped isoform of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 310, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR" } }, { "url": "https://www.uniprot.org/uniprot/A2A6M5#A2A6M5-2", "isoform_ac": "A2A6M5-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2A6M5-2|CACO2_MOUSE Isoform 2 of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 261, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR" } }, { "url": "https://www.uniprot.org/uniprot/A2A6M5#A2A6M5-3", "isoform_ac": "A2A6M5-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2A6M5-3|CACO2_MOUSE Isoform 3 of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 233, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEVKAYWWNDLHR" } }, { "url": "https://www.uniprot.org/uniprot/A2A6M5#A2A6M5-4", "isoform_ac": "A2A6M5-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2A6M5-4|CACO2_MOUSE Isoform 4 of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 240, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR" } }, { "url": "https://www.uniprot.org/uniprot/A2A6M5#A2A6M5-5", "isoform_ac": "A2A6M5-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2A6M5-5|CACO2_MOUSE Isoform 5 of Calcium-binding and coiled-coil domain-containing protein 2 OS=Mus musculus OX=10090 GN=Calcoco2 PE=2 SV=1 CANONICAL=A2A6M5-1", "length": 233, "sequence": "MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:76815", "resource": "KEGG Pathway", "id": "mmu:76815", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5#function", "annotation": "Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5#function", "id": "A2A6M5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "annotation": "Expression and association of NDP52 with autophagy-regulated gene proteins including LC3, as well as phosphorylated tau and amyloid-beta in brains of an Alzheimer disease model", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "annotation": "The authors conclude that the dispersion of ND10 by major immediate-early protein 1 (IE1) appears not to be important for murine cytomegalovirus replication in a mouse-cell culture.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "annotation": "ND10 and ND10 components might be important defensive factors against the CMV cross-species infection Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" } ] } ], "orthologs": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "ac": "NP_001257947.1", "name": "calcium-binding and coiled-coil domain-containing protein 2; nuclear domain 10 protein 52 like 1; nuclear domain 10 protein NDP52.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "autophagosome membrane", "id": "GO:0000421" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "autophagosome", "id": "GO:0005776" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "PML body", "id": "GO:0016605" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901098", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "positive regulation of autophagosome maturation", "id": "GO:1901098" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098792", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "id": "A2A6M5", "database": "UniProtKB" } ], "name": "xenophagy", "id": "GO:0098792" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 16, "annotation": "n_glycosylation_sequon", "start_pos": 14 }, { "end_pos": 181, "annotation": "n_glycosylation_sequon", "start_pos": 179 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257947.1", "id": "NP_001257947.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:76815", "id": "mmu:76815", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000006056", "id": "ENSMUSG00000006056", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "id": "IPR041611", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF17751", "id": "PF17751", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A6M5", "id": "PR_A2A6M5", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/76815", "id": "76815", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1343177", "id": "1343177", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A6M5", "disease": [], "mass": { "monoisotopic_mass": 40136.0, "chemical_mass": 40136.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A6M5", "name": "Calcoco2; Ndp52; Ndp52l1; 2410154J16Rik; C77254.", "locus": { "end_pos": 96099326, "start_pos": 96111964, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000006056", "id": "ENSMUSG00000006056", "database": "Ensembl Gene" } ] } } ] }