{ "uniprot_canonical_ac": "A2A5N3-1", "sequence": { "header": "tr|A2A5N3-1|A2A5N3_MOUSE Isoform 1 of Polyadenylate-binding protein OS=Mus musculus OX=10090 GN=Pabpc1l PE=2 SV=1 CANONICAL=A2A5N3-1", "length": 607, "sequence": "MDTGGHGCSLSSLYVGDLHPDVTESMLYEMFSPIGNILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEVIKGQPIRIMWSHRDPGLRKSGMGNIFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQSVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQSELKRRFEQMKQERQNRYQGVNLYVKNLDDSINDERLKEVFSTYGVITSAKVMTESSHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRPSHPVLSSFQQPTSYLLPAVPQSTAQAVYYSSGSITPMQPDPRWTAQPHGPPSTCPPAASVVQPLSTTQHPCIHLRGASQVSSQVPHTQRVVNIGTQTTGPGGEGSSIPGQLLVPHRGTSAVHSAHGVQESAVYVPGHQPLTVSMLAAAPLHEQKQMIGERLYSLIHDACAPLTGKITGMLLELDNLELLLLLESPESLHAKIEEAVAVLQVHREMESTDRN" }, "uniprot_id": "A2A5N3_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "polyadenylate-binding protein 1-like", "embryonic poly(A)-binding protein" ], "uniprotkb": [ "Polyadenylate-binding protein", "PABP" ] }, "gene": { "refseq": [ "Pabpc1l", "1810053B01Rik", "Epab" ], "uniprotkb": [ "Pabpc1l", "Epab", "1810053B01Rik" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Polyadenylate-binding protein; PABP.", "short": "PABP" }, "publication": [ { "title": "Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30302808", "journal": "Journal of cellular biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" } ], "authors": "Uysal F, Ozturk S", "date": "2019", "pmid": "30302808" }, { "title": "Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25370180", "journal": "Journal of assisted reproduction and genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" } ], "authors": "Ozturk S, Sozen B, Demir N", "date": "2015", "pmid": "25370180" }, { "title": "Epab and Pabpc1 are differentially expressed during male germ cell development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22814100", "journal": "Reproductive sciences (Thousand Oaks, Calif.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" } ], "authors": "Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E", "date": "2012", "pmid": "22814100" }, { "title": "An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15630085", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A5N3/publications", "id": "A2A5N3", "database": "UniProtKB" } ], "authors": "Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA", "date": "2005", "pmid": "15630085" }, { "title": "Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15475267", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" } ], "authors": "Kuninger D, Kuzmickas R, Peng B, Pintar JE, Rotwein P", "date": "2004", "pmid": "15475267" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3#A2A5N3-1", "isoform_ac": "A2A5N3-1", "locus": { "end_pos": 164025481, "start_pos": 164050036, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000067715", "id": "ENSMUST00000067715", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000096701", "id": "ENSMUSP00000096701", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A5N3-1|A2A5N3_MOUSE Isoform 1 of Polyadenylate-binding protein OS=Mus musculus OX=10090 GN=Pabpc1l PE=2 SV=1 CANONICAL=A2A5N3-1", "length": 607, "sequence": "MDTGGHGCSLSSLYVGDLHPDVTESMLYEMFSPIGNILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEVIKGQPIRIMWSHRDPGLRKSGMGNIFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQSVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQSELKRRFEQMKQERQNRYQGVNLYVKNLDDSINDERLKEVFSTYGVITSAKVMTESSHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRPSHPVLSSFQQPTSYLLPAVPQSTAQAVYYSSGSITPMQPDPRWTAQPHGPPSTCPPAASVVQPLSTTQHPCIHLRGASQVSSQVPHTQRVVNIGTQTTGPGGEGSSIPGQLLVPHRGTSAVHSAHGVQESAVYVPGHQPLTVSMLAAAPLHEQKQMIGERLYSLIHDACAPLTGKITGMLLELDNLELLLLLESPESLHAKIEEAVAVLQVHREMESTDRN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:381404", "resource": "KEGG Pathway", "id": "mmu:381404", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3#function", "annotation": "Binds the poly(A) tail of mRNA.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3#function", "id": "A2A5N3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "annotation": "These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "annotation": "In mature testis the highest levels of Epab are in spermatogonia, while Pabpc1 expression is detected in spermatocytes and round spermatids.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAS7-1", "protein_name": "Polyadenylate-binding protein; PABP.", "sequence": { "length": 607, "sequence": "MDTRGHGCSLSSLYVGDLHPDVTEAMLYEMFSPIGTILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEMIKGQPIRIMWSHRDPGLRRSGMGNIFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLRVDMDEQGLQDLFSQFGKTQSVKVMRDSNGQSRGFGFINFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQNELKRRFEQMKQERQNRYQGVNLYVKNLDDSINDDRLKEVFSTYGVITSAKVMTESSHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRLSRSVLSSFQQPTSYLLPAVHQSTTQTMYYSSASIAPMQPDPRWTAQPHGPSSTCPPAASVVQPLSTAPHPCIHLSSASQASSQVPHTQRVVNIGTQTTGPGGEGSCIPGQPLLAHRGSSAVHSAHGVQESTVYVPGHQPLTVSMLDAAPLHEQKQMIGERLYSLIHDACAPLTGKITGMLLEMDNLELLLLLESPESLHAKIEEAVAVLKAHRAMESADSY" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A5N3/", "id": "A2A5N3", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q4VXU2-1", "protein_name": "Polyadenylate-binding protein 1-like.", "sequence": { "length": 614, "sequence": "MNASGSGYPLASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEMLKGQPIRIMWSQRDPGLRKSGVGNIFIKNLEDSIDNKALYDTFSTFGNILSCKVACDEHGSRGFGFVHFETHEAAQQAINTMNGMLLNDRKVFVGHFKSRREREAELGARALEFTNIYVKNLPVDVDEQGLQDLFSQFGKMLSVKVMRDNSGHSRCFGFVNFEKHEEAQKAVVHMNGKEVSGRLLYAGRAQKRVERQNELKRRFEQMKQDRLRRYQGVNLYVKNLDDSIDDDKLRKEFSPYGVITSAKVMTEGGHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYMQRLSTMRTLSNPLLGSFQQPSSYFLPAMPQPPAQAAYYGCGPVTPTQPAPRWTSQPPRPSCASMVRPPVVPRRPPAHISSVRQASTQVPRTVPHTQRVANIGTQTTGPSGVGCCTPGRPLLPCKCSSAAHSTYRVQEPAVHIPGQEPLTASMLAAAPLHEQKQMIGERLYPLIHDVHTQLAGKITGMLLEIDNSELLLMLESPESLHAKIDEAVAVLQAHQAMEQPKAYMH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/77989", "id": "77989", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "ac": "NP_001107551.1", "name": "polyadenylate-binding protein 1-like; embryonic poly(A)-binding protein.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "mRNA 3'-UTR binding", "id": "GO:0003730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "poly(A) binding", "id": "GO:0008143" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "poly(U) RNA binding", "id": "GO:0008266" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "cytoplasmic stress granule", "id": "GO:0010494" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "ribonucleoprotein complex", "id": "GO:1990904" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "chromatin remodeling", "id": "GO:0006338" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006378", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "mRNA polyadenylation", "id": "GO:0006378" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001556", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "oocyte maturation", "id": "GO:0001556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "chromatin-mediated maintenance of transcription", "id": "GO:0048096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051647", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "id": "A2A5N3", "database": "UniProtKB" } ], "name": "nucleus localization", "id": "GO:0051647" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551.1", "id": "NP_001107551.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:381404", "id": "mmu:381404", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000054582", "id": "ENSMUSG00000054582", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/DHMNGKE/", "id": "DHMNGKE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "id": "IPR035979", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "id": "IPR000504", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002004", "id": "IPR002004", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036053", "id": "IPR036053", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "id": "IPR003954", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006515", "id": "IPR006515", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "id": "IPR012677", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00076", "id": "PF00076", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00658", "id": "PF00658", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/381404", "id": "381404", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1922908", "id": "1922908", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2A5N3", "disease": [], "mass": { "monoisotopic_mass": 67433.0, "chemical_mass": 67433.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A5N3", "name": "Pabpc1l; Epab; 1810053B01Rik.", "locus": { "end_pos": 164050538, "start_pos": 164025450, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000054582", "id": "ENSMUSG00000054582", "database": "Ensembl Gene" } ] } } ] }