{ "uniprot_canonical_ac": "A2A5K6-1", "sequence": { "header": "sp|A2A5K6-1|ZN335_MOUSE Isoform 1 of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1", "length": 1337, "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPLSSPGPEAPQEPAPFQSPETPPLLCPDALGGTTIIYQQGAEESTAVATQTALDLLLNMSAQRELGATALQVAVVKSEGIEAELTSTGGQPSPEDTTPRVVTLHMAESGSSVAAESQLGPSDLQQIALPSGPFGGASYSVITAPPVEGRTSASGPPYREEPPGEAAQAVVVSDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGSEVLSPTKTHHMGGSQGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSSHGVLGTERLQQALSQEHIIVAQEQTVTNQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEQIHQLQHQGIEYDVITLSDD" }, "uniprot_id": "ZN335_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "zinc finger protein 335", "NRC-interacting factor 1" ], "uniprotkb": [ "Zinc finger protein 335", "NRC-interacting factor 1", "NIF-1" ] }, "gene": { "refseq": [ "Zfp335", "1810045J01Rik", "NIF-1", "Nif1", "Znf335" ], "uniprotkb": [ "Znf335", "Zfp335", "1810045J01Rik", "NIF-1", "Nif1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Zinc finger protein 335; NRC-interacting factor 1; NIF-1." }, "publication": [ { "title": "NRC-interacting factor directs neurite outgrowth in an activity-dependent manner.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25573434", "journal": "Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ], "authors": "Zhao XS, Fu WY, Hung KW, Chien WW, Li Z, Fu AK, Ip NY", "date": "2015", "pmid": "25573434" }, { "title": "p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25329792", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ], "authors": "Zhao XS, Fu WY, Chien WW, Li Z, Fu AK, Ip NY", "date": "2014", "pmid": "25329792" }, { "title": "Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25343476", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ], "authors": "Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG", "date": "2014", "pmid": "25343476" }, { "title": "Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23178126", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A5K6/publications", "id": "A2A5K6", "database": "UniProtKB" } ], "authors": "Yang YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J, Tatarakis A, Mahajan MA, Samuels HH, Shi Y, Golden JA, Mahajnah M, Shenhav R, Walsh CA", "date": "2012", "pmid": "23178126" }, { "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003", "pmid": "12520002" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6#A2A5K6-1", "isoform_ac": "A2A5K6-1", "locus": { "end_pos": 164892167, "start_pos": 164910822, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000041361", "id": "ENSMUST00000041361", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000038298", "id": "ENSMUSP00000038298", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A5K6-1|ZN335_MOUSE Isoform 1 of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1", "length": 1337, "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPLSSPGPEAPQEPAPFQSPETPPLLCPDALGGTTIIYQQGAEESTAVATQTALDLLLNMSAQRELGATALQVAVVKSEGIEAELTSTGGQPSPEDTTPRVVTLHMAESGSSVAAESQLGPSDLQQIALPSGPFGGASYSVITAPPVEGRTSASGPPYREEPPGEAAQAVVVSDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGSEVLSPTKTHHMGGSQGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSSHGVLGTERLQQALSQEHIIVAQEQTVTNQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEQIHQLQHQGIEYDVITLSDD" } }, { "url": "https://www.uniprot.org/uniprot/A2A5K6#S4R2J0-1", "isoform_ac": "S4R2J0-1", "locus": { "end_pos": 164906383, "start_pos": 164907665, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000139247", "id": "ENSMUST00000139247", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000138664", "id": "ENSMUSP00000138664", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|S4R2J0-1|ZN335_MOUSE Computationally mapped isoform of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1", "length": 91, "sequence": "HFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEGTLLCFSLVLGLRCHALLLDMGSGRLNSDSHAPQQILH" } }, { "url": "https://www.uniprot.org/uniprot/A2A5K6#Q6P5F4-1", "isoform_ac": "Q6P5F4-1", "locus": { "end_pos": 164900023, "start_pos": 164910822, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000183830", "id": "ENSMUST00000183830", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000139133", "id": "ENSMUSP00000139133", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q6P5F4-1|ZN335_MOUSE Computationally mapped isoform of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1", "length": 598, "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKIQV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:329559", "resource": "KEGG Pathway", "id": "mmu:329559", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6#function", "annotation": "Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6#function", "id": "A2A5K6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "annotation": "Results suggest that NIF-1 directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "annotation": "Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "annotation": "P35 interacts with NIF-1 and regulates the subcellular localization of the protein independent of Cdk5-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5 Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "annotation": "Znf335 null mice are embryonically lethal, and conditional knockout leads to severely reduced cortical size.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "id": "NP_950192.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9H4Z2-1", "protein_name": "Zinc finger protein 335; NRC-interacting factor 1; NIF-1.", "sequence": { "length": 1342, "sequence": "MEENEVESSSDAAPGPGRPEEPSESGLGVGTSEAVSADSSDAAAAPGQAEADDSGVGQSSDRGSRSQEEVSESSSSADPLPNSYLPDSSSVSHGPVAGVTGGPPALVHSSALPDPNMLVSDCTASSSDLGSAIDKIIESTIGPDLIQNCITVTSAEDGGAETTRYLILQGPDDGAPMTSPMSSSTLAHSLAAIEALADGPTSTSTCLEAQGGPSSPVQLPPASGAEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPVAAAAAAAGKKGRLRKWSTSTKSQEEEGPEEEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGGTALQVAVVKSEDVEAGLASPGGQPSPEGATPQVVTLHVAEPGGGAAAESQLGPPDLPQITLAPGPFGGTGYSVITAPPMEEGTSAPGTPYSEEPAGEAAQAVVVSDTLKEAGTHYIMATDGTQLHHIELTADGSISFPSPDALASGAKWPLLQCGGLPRDGPEPPSPAKTHCVGDSQSSASSPPATSKALGLAVPPSPPSAATAASKKFSCKICAEAFPGRAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTKEKPFACHLCGQRFNRNGHLKFHIQRLHSPDGRKSGTPTARAPTQTPTQTIILNSDDETLATLHTALQSSHGVLGPERLQQALSQEHIIVAQEQTVTNQEEAAYIQEITTADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTDETVPEHIQQLQHQGIEYDVITLADD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11129", "id": "11129", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A5K6/", "id": "A2A5K6", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "G3V893-1", "protein_name": "Zinc finger protein 335; NRC-interacting factor 1; NIF-1.", "sequence": { "length": 1336, "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVGTSEAVSADSTDAATAPGLTEADDSGVGQSSDSGSRSVEEVSESISTEPLPQGYLPDSSSVSRGPVAEVPGGPPALVHSSALPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSTCLEPAEQPPGEPSSLAQPPAPVVEELDLQGLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAVAAAAAGKRGRVRKWGTSTKTTEEEGPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTLRPRRRPGRPRKLPRLETSDLHDGIGEPLVSSQSTQSPPELQDLEAPSSSDLRALGKVGRGLVETGVSQSDAENAAPSCQDEADVPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPLSSAGPEAPQEPAPFQPPETPPLLCPDALGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGATALQVAVVKSEDVEAELTSTARQPSSEDTTPRVVTLHVAESGSSVAAESQLGPSDLQQIALPPGPFSGASYSVITAPPVEGRASASGPPYREEPPGEAAQAVVVNDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGPEVLSPTKTHHTGGSQGSSTPPPATSHALGLLVPHSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSNHGTLGTERLQQALSQEHIIVAQEQTVANQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLSDD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11129", "id": "11129", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192.2", "ac": "NP_950192.2", "name": "zinc finger protein 335; NRC-interacting factor 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000979", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "RNA polymerase II core promoter sequence-specific DNA binding", "id": "GO:0000979" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035097", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "histone methyltransferase complex", "id": "GO:0035097" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "in utero embryonic development", "id": "GO:0001701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "neuron projection morphogenesis", "id": "GO:0048812" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "brain development", "id": "GO:0007420" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "regulation of gene expression", "id": "GO:0010468" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048854", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "brain morphogenesis", "id": "GO:0048854" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "regulation of neurogenesis", "id": "GO:0050767" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002052", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "positive regulation of neuroblast proliferation", "id": "GO:0002052" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021895", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6", "database": "UniProtKB" } ], "name": "cerebral cortex neuron 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