{
    "uniprot_canonical_ac": "A2A3K4-1", 
    "sequence": {
        "header": "sp|A2A3K4-1|PTPC1_HUMAN Isoform 1 of Protein tyrosine phosphatase domain-containing protein 1  OS=Homo sapiens OX=9606 GN=PTPDC1 PE=1 SV=1 CANONICAL=A2A3K4-1", 
        "length": 754, 
        "sequence": "MAAGVLPQNEQPYSTLVNNSECVANMKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL"
    }, 
    "uniprot_id": "PTPC1_HUMAN", 
    "enzyme_annotation": [
        {
            "ec": "3.1.3.-", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "protein tyrosine phosphatase domain-containing protein 1 isoform 3", 
                "protein tyrosine phosphatase PTP9Q22; protein tyrosine phosphatase domain-containing protein 1"
            ], 
            "uniprotkb": [
                "Protein tyrosine phosphatase domain-containing protein 1", 
                "3.1.3.-"
            ]
        }, 
        "gene": {
            "refseq": [
                "PTPDC1", 
                "PTP9Q22"
            ], 
            "uniprotkb": [
                "PTPDC1", 
                "PTP9Q22"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Protein tyrosine phosphatase domain-containing protein 1; 3.1.3.-."
    }, 
    "publication": [
        {
            "title": "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24121790", 
            "journal": "Nature genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240758.1", 
                    "id": "NP_001240758.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyren O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL", 
            "date": "2013", 
            "pmid": "24121790"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 153, 
            "subjects_positive": "4", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.7", 
            "annotation": "Filters passed (2/5): patient freq. (2.7%); num. of cancers (4).", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "150", 
            "end_pos": 153, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 153, 
            "subjects_positive": "9", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.3", 
            "annotation": "Filters passed (2/5): patient freq. (1.3%); num. of cancers (4).", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "1319", 
                "url": "http://disease-ontology.org/term/DOID:1319", 
                "icd10": "", 
                "name": "Brain cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "678", 
            "end_pos": 153, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 269, 
            "subjects_positive": "4", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.7", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs376544074.", 
            "sequence_org": "R", 
            "disease": {
                "doid": "363", 
                "url": "http://disease-ontology.org/term/DOID:363", 
                "icd10": "", 
                "name": "Uterine cancer"
            }, 
            "sequence_mut": "C", 
            "subjects_tested": "558", 
            "end_pos": 269, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 657, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "K", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "50", 
            "end_pos": 657, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 221, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs547059455.", 
            "sequence_org": "R", 
            "disease": {
                "doid": "263", 
                "url": "http://disease-ontology.org/term/DOID:263", 
                "icd10": "", 
                "name": "Kidney cancer"
            }, 
            "sequence_mut": "W", 
            "subjects_tested": "756", 
            "end_pos": 221, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 153, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.2", 
            "annotation": "Filters passed (1/5): num. of cancers (4).", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "456", 
            "end_pos": 153, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 153, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.4", 
            "annotation": "Filters passed (1/5): num. of cancers (4).", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "263", 
                "url": "http://disease-ontology.org/term/DOID:263", 
                "icd10": "", 
                "name": "Kidney cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "756", 
            "end_pos": 153, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 214, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.0", 
            "annotation": "Filters passed (1/5): patient freq. (1.0%). In dbSNP: rs549853437.", 
            "sequence_org": "D", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "Urinary bladder cancer"
            }, 
            "sequence_mut": "N", 
            "subjects_tested": "103", 
            "end_pos": 214, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 208, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "50", 
            "end_pos": 208, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 571, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "L", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "50", 
            "end_pos": 571, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 269, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs376544074.", 
            "sequence_org": "R", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "Urinary bladder cancer"
            }, 
            "sequence_mut": "C", 
            "subjects_tested": "742", 
            "end_pos": 269, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 221, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs547059455.", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1319", 
                "url": "http://disease-ontology.org/term/DOID:1319", 
                "icd10": "", 
                "name": "Brain cancer"
            }, 
            "sequence_mut": "W", 
            "subjects_tested": "678", 
            "end_pos": 221, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 221, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs547059455.", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "W", 
            "subjects_tested": "2203", 
            "end_pos": 221, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 269, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs376544074.", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "C", 
            "subjects_tested": "1144", 
            "end_pos": 269, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A3K4#A2A3K4-1", 
            "isoform_ac": "A2A3K4-1", 
            "locus": {
                "end_pos": 94064740, 
                "start_pos": 94107941, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000650567", 
                        "id": "ENST00000650567", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000497158", 
                        "id": "ENSP00000497158", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A3K4-1|PTPC1_HUMAN Isoform 1 of Protein tyrosine phosphatase domain-containing protein 1  OS=Homo sapiens OX=9606 GN=PTPDC1 PE=1 SV=1 CANONICAL=A2A3K4-1", 
                "length": 754, 
                "sequence": "MAAGVLPQNEQPYSTLVNNSECVANMKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A3K4#A0A087WTF0-1", 
            "isoform_ac": "A0A087WTF0-1", 
            "locus": {
                "end_pos": 94084531, 
                "start_pos": 94107941, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000620992", 
                        "id": "ENST00000620992", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000477817", 
                        "id": "ENSP00000477817", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A087WTF0-1|PTPC1_HUMAN Computationally mapped isoform of Protein tyrosine phosphatase domain-containing protein 1  OS=Homo sapiens OX=9606 GN=PTPDC1 PE=1 SV=1 CANONICAL=A2A3K4-1", 
                "length": 808, 
                "sequence": "MQVQDATRRPSAVRFLSSFLQGRRHSTSDPVLRLQQARRGSGLGSGSATKLLSSSSLQVMVAVSSVSHAEGNPTFPERKSKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A3K4#A2A3K4-2", 
            "isoform_ac": "A2A3K4-2", 
            "locus": {
                "end_pos": 94084531, 
                "start_pos": 94107941, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000288976", 
                        "id": "ENST00000288976", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000288976", 
                        "id": "ENSP00000288976", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A3K4-2|PTPC1_HUMAN Isoform 2 of Protein tyrosine phosphatase domain-containing protein 1  OS=Homo sapiens OX=9606 GN=PTPDC1 PE=1 SV=1 CANONICAL=A2A3K4-1", 
                "length": 806, 
                "sequence": "MQVQDATRRPSAVRFLSSFLQGRRHSTSDPVLRLQQARRGSGLGSGSATKLLSSSSLQVMVAVSSVSHAEGNPTFPERKRNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:138639", 
            "resource": "KEGG Pathway", 
            "id": "hsa:138639", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A3K4#function", 
            "annotation": "May play roles in cilia formation and/or maintenance.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A3K4#function", 
                    "id": "A2A3K4", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2KB18-1", 
            "protein_name": "Protein tyrosine phosphatase domain-containing 1.", 
            "sequence": {
                "length": 796, 
                "sequence": "MYLALLEILESGSILFKGASIAHTSDGAEKGEKQGAKPDRSLETRMAAGVLPQNENPYSTLVNDSGHAAYMDENSGRPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIEQFLSHGIKTIINLQRPGEHASCGNSLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLMRQRHLLHGYEARLLKYVPKIVHLVCKLLLDVAENRPVVMKSVLEGPELSAEIEKTVSEMVTMQLDQELLRQNSDVPDPFNPTAEVAEFDSQDVILSNEHEFDPLWKRRNIERLQPLTHLKRQLSYSDSDLKRAKAILEQGETPWTVPAQELLDHSLQQQTPTSHCFLPPTPELGLHKDTLVRNTFSFWTESKCGGLEEPKDEGSLLLCRKDSPKEVQRSRTFSVGVSCSHNPGEPAPPNFTRTHKDSERGAHCRCEAPEGWVPGPVPKMGRSPCSPLHCDTSPKAQFSCGQETQDSTYLPEATPHAGLQSELNAEARRILAAKALANLTEFVEEEEVKRRVEMWQKELNSREGAWERICGERDPFILCSLMWSWVEQLKEPVISKEDVDMLVDRHADAAEALFLLEKGQYQTILCVLHCIVSLQTLPVEVEEACLSHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRKMAKDSPRPGLS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/17576", 
                    "id": "17576", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q6NZK8-1", 
            "protein_name": "Protein tyrosine phosphatase domain-containing protein 1; 3.1.3.-.", 
            "sequence": {
                "length": 747, 
                "sequence": "MAAGVLPQNEDPYSTLVNSSGHAAHMDENSGRPAPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYRIIEQFLGQGIKTIINLQRPGEHASCGSALEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLIRQRHLLHGYEARLLKYVPKIIHLVCKLLLDLAENRPVVMKSMLEGPVLSAEIEKTVSEMVTLQLDQELLRQNSDVPDPFNPTAEVAEFENQDVILSTEQEFDPLWKRRDIECLQPLTHLKRQLSYSDSDLKRAKAILEQGETPWTVPAQELLDHSLQHQKPTSHCYMPPTPELGFNKEALVQNTFSFWTPSKCGGLEGLKDEGSLLLCRKDIPKEVQRSRTFSVGVSCSHNPGEPVPPNFTSIHKDPEQVTHCRCEAPGGWVPGPVHEMVRSPCSPLNCGSSPKAQFPHGQETQDSTDLSEAVPHAGLQPELSAEARRILAAKALANLNEFVEKEEVKRKVEMWQKELNSREEAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRQADAAEALFLLEKGQYQTILCVLHCIVSLQTLPMEVEEACLLHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRKMAKDSLS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/17576", 
                    "id": "17576", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240758.1", 
        "ac": "NP_001240758.1", 
        "name": "protein tyrosine phosphatase domain-containing protein 1 isoform 3; protein tyrosine phosphatase PTP9Q22; protein tyrosine phosphatase domain-containing protein 1.", 
        "summary": "The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A3K4", 
                                "id": "A2A3K4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein tyrosine phosphatase activity", 
                        "id": "GO:0004725"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008138", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A3K4", 
                                "id": "A2A3K4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein tyrosine/serine/threonine phosphatase activity", 
                        "id": "GO:0008138"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A3K4", 
                                "id": "A2A3K4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A3K4", 
                                "id": "A2A3K4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A3K4", 
                                "id": "A2A3K4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cilium assembly", 
                        "id": "GO:0060271"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 20, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 18
        }, 
        {
            "end_pos": 472, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 470
        }, 
        {
            "end_pos": 603, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 601
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240758.1", 
            "id": "NP_001240758.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30184", 
            "id": "30184", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A2A3K4", 
            "id": "A2A3K4", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A2A3K4", 
            "id": "NX_A2A3K4", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PTPDC1", 
            "id": "PTPDC1", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:138639", 
            "id": "hsa:138639", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
            "id": "ENSG00000158079", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", 
            "id": "IPR000340", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", 
            "id": "IPR000387", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", 
            "id": "IPR003595", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", 
            "id": "IPR016130", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", 
            "id": "IPR020422", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", 
            "id": "IPR029021", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00782", 
            "id": "PF00782", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A3K4", 
            "id": "PR_A2A3K4", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A3K4*", 
            "id": "A2A3K4", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/138639", 
            "id": "138639", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Up", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A3K4", 
                    "id": "A2A3K4", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A2A3K4", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 84457.0, 
        "chemical_mass": 84457.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000158079", 
                    "id": "ENSG00000158079", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A3K4", 
            "name": "PTPDC1; PTP9Q22.", 
            "locus": {
                "end_pos": 94109856, 
                "start_pos": 94030794, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000158079", 
                        "id": "ENSG00000158079", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}