{
    "uniprot_canonical_ac": "A2A2V5-1", 
    "sequence": {
        "header": "sp|A2A2V5-1|SRTM1_HUMAN Isoform 1 of Serine-rich and transmembrane domain-containing protein 1  OS=Homo sapiens OX=9606 GN=SERTM1 PE=4 SV=1 CANONICAL=A2A2V5-1", 
        "length": 107, 
        "sequence": "MSEPDTSSGFSGSVENGTFLELFPTSLSTSVDPSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS"
    }, 
    "uniprot_id": "SRTM1_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "serine-rich and transmembrane domain-containing protein 1"
            ], 
            "uniprotkb": [
                "Serine-rich and transmembrane domain-containing protein 1"
            ]
        }, 
        "gene": {
            "refseq": [
                "SERTM1", 
                "C13orf36"
            ], 
            "uniprotkb": [
                "SERTM1", 
                "C13orf36"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Serine-rich and transmembrane domain-containing protein 1."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 42, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (1/5): patient freq. (1.1%).", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "93", 
            "end_pos": 42, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 74, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "S", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "1514", 
            "end_pos": 74, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 74, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "S", 
            "disease": {
                "doid": "1319", 
                "url": "http://disease-ontology.org/term/DOID:1319", 
                "icd10": "", 
                "name": "Brain cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "678", 
            "end_pos": 74, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 74, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "S", 
            "disease": {
                "doid": "4159", 
                "url": "http://disease-ontology.org/term/DOID:4159", 
                "icd10": "", 
                "name": "Skin cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "820", 
            "end_pos": 74, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A2V5#A2A2V5-1", 
            "isoform_ac": "A2A2V5-1", 
            "locus": {
                "end_pos": 36695079, 
                "start_pos": 36695399, 
                "chromosome": "13", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000315190", 
                        "id": "ENST00000315190", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000325776", 
                        "id": "ENSP00000325776", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A2V5-1|SRTM1_HUMAN Isoform 1 of Serine-rich and transmembrane domain-containing protein 1  OS=Homo sapiens OX=9606 GN=SERTM1 PE=4 SV=1 CANONICAL=A2A2V5-1", 
                "length": 107, 
                "sequence": "MSEPDTSSGFSGSVENGTFLELFPTSLSTSVDPSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:400120", 
            "resource": "KEGG Pathway", 
            "id": "hsa:400120", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZR22-1", 
            "protein_name": "RCG50030; Serine-rich and transmembrane domain-containing 1.", 
            "sequence": {
                "length": 107, 
                "sequence": "MSEADPSSGFAGSVENGTFLELFPTSLSTSVDSSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2A2V5/", 
                    "id": "A2A2V5", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/45594", 
                    "id": "45594", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8CD78-1", 
            "protein_name": "Serine-rich and transmembrane domain-containing protein 1.", 
            "sequence": {
                "length": 107, 
                "sequence": "MSEADSSSGFAGSVENGTFLELFPTSLSTSVDSSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/45594", 
                    "id": "45594", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_982276.2", 
        "ac": "NP_982276.2", 
        "name": "serine-rich and transmembrane domain-containing protein 1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A2V5", 
                                "id": "A2A2V5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A2V5", 
                                "id": "A2A2V5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular membrane-bounded organelle", 
                        "id": "GO:0043231"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 18, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 16
        }, 
        {
            "end_pos": 106, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 104
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_982276.2", 
            "id": "NP_982276.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33792", 
            "id": "33792", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A2A2V5", 
            "id": "A2A2V5", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A2A2V5", 
            "id": "NX_A2A2V5", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SERTM1", 
            "id": "SERTM1", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:400120", 
            "id": "hsa:400120", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
            "id": "ENSG00000180440", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/VYVYVWL/", 
            "id": "VYVYVWL", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031741", 
            "id": "IPR031741", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15872", 
            "id": "PF15872", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35660", 
            "id": "PTHR35660", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A2V5", 
            "id": "PR_A2A2V5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A2V5*", 
            "id": "A2A2V5", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/400120", 
            "id": "400120", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2A2V5", 
                    "id": "A2A2V5", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A2A2V5", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 11458.0, 
        "chemical_mass": 11458.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000180440", 
                    "id": "ENSG00000180440", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A2V5", 
            "name": "SERTM1; C13orf36.", 
            "locus": {
                "end_pos": 36697839, 
                "start_pos": 36673912, 
                "chromosome": "13", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000180440", 
                        "id": "ENSG00000180440", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}