{
    "uniprot_canonical_ac": "A1Y9I9-1", 
    "sequence": {
        "header": "sp|A1Y9I9-1|TOMT_MOUSE Isoform 1 of Transmembrane O-methyltransferase homolog  OS=Mus musculus OX=10090 GN=Tomt PE=1 SV=1 CANONICAL=A1Y9I9-1", 
        "length": 258, 
        "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG"
    }, 
    "uniprot_id": "TOMT_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.1.1.6", 
            "activity": "S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol."
        }, 
        {
            "ec": "2.1.1.6", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "transmembrane O-methyltransferase homolog", 
                "catechol O-methyltransferase 2"
            ], 
            "uniprotkb": [
                "Transmembrane O-methyltransferase homolog", 
                "mTOMT", 
                "2.1.1.6", 
                "Protein LRTOMT2", 
                "Catechol O-methyltransferase 2"
            ]
        }, 
        "gene": {
            "refseq": [
                "Tomt", 
                "Comt2", 
                "F930017I19Rik"
            ], 
            "uniprotkb": [
                "Tomt", 
                "Comt2", 
                "F930017I19Rik"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                    "id": "A1Y9I9", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Transmembrane O-methyltransferase homolog; mTOMT; 2.1.1.6; Protein LRTOMT2; Catechol O-methyltransferase 2.", 
        "short": "mTOMT"
    }, 
    "publication": [
        {
            "title": "The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28504928", 
            "journal": "eLife", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
                    "id": "NP_001075148.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Cunningham CL, Wu Z, Jafari A, Zhao B, Schrode K, Harkins-Perry S, Lauer A, Muller U", 
            "date": "2017", 
            "pmid": "28504928"
        }, 
        {
            "title": "Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18953341", 
            "journal": "Nature genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
                    "id": "NP_001075148.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A1Y9I9/publications", 
                    "id": "A1Y9I9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Ahmed ZM, Masmoudi S, Kalay E, Belyantseva IA, Mosrati MA, Collin RW, Riazuddin S, Hmani-Aifa M, Venselaar H, Kawar MN, Tlili A, van der Zwaag B, Khan SY, Ayadi L, Riazuddin SA, Morell RJ, Griffith AJ, Charfedine I, Caylan R, Oostrik J, Karaguzel A, Ghorbel A, Riazuddin S, Friedman TB, Ayadi H, Kremer H", 
            "date": "2008", 
            "pmid": "18953341"
        }, 
        {
            "title": "A catechol-O-methyltransferase that is essential for auditory function in mice and humans.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18794526", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
                    "id": "NP_001075148.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A1Y9I9/publications", 
                    "id": "A1Y9I9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Muller U, Beutler B", 
            "date": "2008", 
            "pmid": "18794526"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1Y9I9#A1Y9I9-1", 
            "isoform_ac": "A1Y9I9-1", 
            "locus": {
                "end_pos": 101900306, 
                "start_pos": 101902271, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000106970", 
                        "id": "ENSMUST00000106970", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000102583", 
                        "id": "ENSMUSP00000102583", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1Y9I9-1|TOMT_MOUSE Isoform 1 of Transmembrane O-methyltransferase homolog  OS=Mus musculus OX=10090 GN=Tomt PE=1 SV=1 CANONICAL=A1Y9I9-1", 
                "length": 258, 
                "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:791260", 
            "resource": "KEGG Pathway", 
            "id": "mmu:791260", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-379397", 
            "resource": "Reactome", 
            "id": "R-MMU-379397", 
            "name": "Enzymatic degradation of dopamine by COMT"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1Y9I9#function", 
            "annotation": "Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (PubMed:18794526). Required for auditory function (PubMed:18794526, PubMed:28504928). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (PubMed:28504928).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1Y9I9#function", 
                    "id": "A1Y9I9", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
            "annotation": "These studies thus suggest functional diversification between mCOMT and mTOMT, where mTOMT is critical for the assembly of the mechanotransduction machinery of hair cells. Erratum:[Elife. 2017 Nov 08;6:. PMID: 29116042] Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
                    "id": "NP_001075148.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
            "annotation": "Mice homozygous for a missense mutation in Comt2 show vestibular impairment, profound sensorineuronal deafness, and progressive degeneration of the organ of Corti", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
                    "id": "NP_001075148.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "B6CZ62-1", 
            "protein_name": "Transmembrane O-methyltransferase homolog; 2.1.1.6; Protein LRTOMT2; Catechol O-methyltransferase 2.", 
            "sequence": {
                "length": 258, 
                "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRSFRDCLSGLRIEERAFSYVITHALPGDPGHILTTLDHWSSCCEYLSHMGPIKGQILMRLVEEKAPACVLELGTHCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/19664", 
                    "id": "19664", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8WZ04-1", 
            "protein_name": "Transmembrane O-methyltransferase; 2.1.1.6; Protein LRTOMT2; Catechol O-methyltransferase 2.", 
            "sequence": {
                "length": 291, 
                "sequence": "MGTPWRKRKGIAGPGLPDLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/19664", 
                    "id": "19664", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
        "ac": "NP_001075148.1", 
        "name": "transmembrane O-methyltransferase homolog; catechol O-methyltransferase 2.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016206", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "catechol O-methyltransferase activity", 
                        "id": "GO:0016206"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102084", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "L-dopa O-methyltransferase activity", 
                        "id": "GO:0102084"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102938", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "orcinol O-methyltransferase activity", 
                        "id": "GO:0102938"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum", 
                        "id": "GO:0005783"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "apical part of cell", 
                        "id": "GO:0045177"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904591", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of protein import", 
                        "id": "GO:1904591"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "developmental process", 
                        "id": "GO:0032502"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sensory perception of sound", 
                        "id": "GO:0007605"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sensory perception of sound", 
                        "id": "GO:0007605"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042417", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "dopamine metabolic process", 
                        "id": "GO:0042417"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060117", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "auditory receptor cell development", 
                        "id": "GO:0060117"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042424", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "catecholamine catabolic process", 
                        "id": "GO:0042424"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042135", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
                                "id": "A1Y9I9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "neurotransmitter catabolic process", 
                        "id": "GO:0042135"
                    }
                ], 
                "total": 8, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075148.1", 
            "id": "NP_001075148.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-379397", 
            "id": "R-MMU-379397", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:791260", 
            "id": "mmu:791260", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078630", 
            "id": "ENSMUSG00000078630", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EERAFQY/", 
            "id": "EERAFQY", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002935", 
            "id": "IPR002935", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", 
            "id": "IPR029063", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033025", 
            "id": "IPR033025", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01596", 
            "id": "PF01596", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43836:SF1", 
            "id": "PTHR43836:SF1", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1Y9I9", 
            "id": "PR_A1Y9I9", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/791260", 
            "id": "791260", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3769724", 
            "id": "3769724", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1Y9I9", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 28846.0, 
        "chemical_mass": 28846.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1Y9I9", 
            "name": "Tomt; Comt2; F930017I19Rik.", 
            "locus": {
                "end_pos": 101898370, 
                "start_pos": 101906359, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000078630", 
                        "id": "ENSMUSG00000078630", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}