{ "uniprot_canonical_ac": "A1L1L5-1", "sequence": { "header": "tr|A1L1L5-1|A1L1L5_RAT Isoform 1 of Ccnk protein OS=Rattus norvegicus OX=10116 GN=Ccnk PE=1 SV=1 CANONICAL=A1L1L5-1", "length": 589, "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR" }, "uniprot_id": "A1L1L5_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "cyclin-K" ], "uniprotkb": [ "Ccnk protein", "Cyclin K" ] }, "gene": { "refseq": [ "Ccnk" ], "uniprotkb": [ "Ccnk" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Ccnk protein; Cyclin K." }, "publication": [ { "title": "Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22988298", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", "id": "NP_001103142.1", "database": "RefSeq" } ], "authors": "Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB", "date": "2012", "pmid": "22988298" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5/publications", "id": "A1L1L5", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22547058", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", "id": "NP_001103142.1", "database": "RefSeq" } ], "authors": "Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang S, Song X, Li L, Li Q", "date": "2012", "pmid": "22547058" }, { "title": "The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22012619", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", "id": "NP_001103142.1", "database": "RefSeq" } ], "authors": "Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM", "date": "2011", "pmid": "22012619" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5#A1L1L5-1", "isoform_ac": "A1L1L5-1", "locus": { "end_pos": 132097081, "start_pos": 132112917, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083208", "id": "ENSRNOT00000083208", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074580", "id": "ENSRNOP00000074580", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A1L1L5-1|A1L1L5_RAT Isoform 1 of Ccnk protein OS=Rattus norvegicus OX=10116 GN=Ccnk PE=1 SV=1 CANONICAL=A1L1L5-1", "length": 589, "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:500715", "resource": "KEGG Pathway", "id": "rno:500715", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382", "resource": "Reactome", "id": "R-RNO-112382", "name": "Formation of RNA Pol II elongation complex" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", "resource": "Reactome", "id": "R-RNO-674695", "name": "RNA Polymerase II Pre-transcription Events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955", "resource": "Reactome", "id": "R-RNO-75955", "name": "RNA Polymerase II Transcription Elongation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173796", "resource": "Reactome", "id": "R-RNO-2173796", "name": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648", "resource": "Reactome", "id": "R-RNO-6796648", "name": "TP53 Regulates Transcription of DNA Repair Genes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505", "resource": "Reactome", "id": "R-RNO-6807505", "name": "RNA polymerase II transcribes snRNA genes" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O75909-3", "protein_name": "Cyclin-K.", "sequence": { "length": 580, "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14748", "id": "14748", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1L1L5/", "id": "A1L1L5", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", "ac": "NP_001103142.1", "name": "cyclin-K.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0004693" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008353", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "RNA polymerase II CTD heptapeptide repeat kinase activity", "id": "GO:0008353" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008024", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cyclin/CDK positive transcription elongation factor complex", "id": "GO:0008024" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cyclin K-CDK12 complex", "id": "GO:0002944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002945", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cyclin K-CDK13 complex", "id": "GO:0002945" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032786", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "positive regulation of DNA-templated transcription, elongation", "id": "GO:0032786" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071157", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "negative regulation of cell cycle arrest", "id": "GO:0071157" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044828", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "negative regulation by host of viral genome replication", "id": "GO:0044828" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "id": "A1L1L5", "database": "UniProtKB" } ], "name": "positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues", "id": "GO:2001165" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 9, "annotation": "n_glycosylation_sequon", "start_pos": 7 }, { "end_pos": 192, "annotation": "n_glycosylation_sequon", "start_pos": 190 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", "id": "NP_001103142.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382", "id": "R-RNO-112382", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", "id": "R-RNO-674695", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955", "id": "R-RNO-75955", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173796", "id": "R-RNO-2173796", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648", "id": "R-RNO-6796648", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505", "id": "R-RNO-6807505", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:500715", "id": "rno:500715", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006985", "id": "ENSRNOG00000006985", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/GRATWMR/", "id": "GRATWMR", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00043", "id": "cd00043", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "id": "IPR006671", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "id": "IPR013763", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "id": "IPR036915", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", "id": "IPR004367", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00134", "id": "PF00134", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02984", "id": "PF02984", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/500715", "id": "500715", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1595690", "id": "1595690", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A1L1L5", "disease": [], "mass": { "monoisotopic_mass": 65367.0, "chemical_mass": 65367.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1L1L5", "name": "Ccnk.", "locus": { "end_pos": 132113557, "start_pos": 132090218, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000006985", "id": "ENSRNOG00000006985", "database": "Ensembl Gene" } ] } } ] }