{
    "uniprot_canonical_ac": "A1L1J9-1", 
    "sequence": {
        "header": "sp|A1L1J9-1|LMF2_RAT Isoform 1 of Lipase maturation factor 2  OS=Rattus norvegicus OX=10116 GN=Lmf2 PE=2 SV=1 CANONICAL=A1L1J9-1", 
        "length": 702, 
        "sequence": "MASARVPQQLFLQGVAAVYLFAFASLYTQIPGLYGPEGILPARRTLRPQGKGRWQQLWETPTILWEAPRLGLDTAQGLDLLTLLGTVLALGALLLNSLRHPFIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAILVAPLRRPSKHKIPQGGLAGALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHRLSVVATFLIEIAVPPLFFAPIRRLRLSAFYAQALLQILIIITGNYNFFNLLTLVLTTALLDDRHLSAEPELRCHKKMPTSWPKTLLTSLSLMLELTVYGLLAYGTIYYFGLEVDWQQQIVLSKTTFTFHQFSQWLKMVTLPTVWLGTASLAWELLIALWRWIQVQGWSRKFFAGIQLSVLGTATVFLFLISLVPYSYVEPGTHGRLWTGAHRLFSSVEHLQLANSYGLFRRMTGLGGRPEVVLEGSHDGHHWTEIEFMYKPGNVSRPPPFLIPHQPRLDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLIQNQVANYPFREQPPTYLRAQRYKYWFSKPGDQSRWWHRQWVEEFFPSVSLGDPTLETLLQQFGLKDKSPPRARSSKNALAQTLNWVRAQLSPLEPSILLWGLLGAVVAIRVVRTLLTPRPLQSSKQTREEKRKQAPKKDSRAVSEQTAPNSNSNGSWAPRRKK"
    }, 
    "uniprot_id": "LMF2_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "lipase maturation factor 2", 
                "transmembrane protein 112B"
            ], 
            "uniprotkb": [
                "Lipase maturation factor 2"
            ]
        }, 
        "gene": {
            "refseq": [
                "Lmf2", 
                "RGD1306274", 
                "Tmem112b"
            ], 
            "uniprotkb": [
                "Lmf2", 
                "RGD1306274", 
                "Tmem112b"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L1J9", 
                    "id": "A1L1J9", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Lipase maturation factor 2."
    }, 
    "publication": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L1J9", 
                    "id": "A1L1J9", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 488, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J9#A1L1J9-1", 
            "isoform_ac": "A1L1J9-1", 
            "locus": {
                "end_pos": 130322480, 
                "start_pos": 130326322, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000049538", 
                        "id": "ENSRNOT00000049538", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000051363", 
                        "id": "ENSRNOP00000051363", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1L1J9-1|LMF2_RAT Isoform 1 of Lipase maturation factor 2  OS=Rattus norvegicus OX=10116 GN=Lmf2 PE=2 SV=1 CANONICAL=A1L1J9-1", 
                "length": 702, 
                "sequence": "MASARVPQQLFLQGVAAVYLFAFASLYTQIPGLYGPEGILPARRTLRPQGKGRWQQLWETPTILWEAPRLGLDTAQGLDLLTLLGTVLALGALLLNSLRHPFIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAILVAPLRRPSKHKIPQGGLAGALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHRLSVVATFLIEIAVPPLFFAPIRRLRLSAFYAQALLQILIIITGNYNFFNLLTLVLTTALLDDRHLSAEPELRCHKKMPTSWPKTLLTSLSLMLELTVYGLLAYGTIYYFGLEVDWQQQIVLSKTTFTFHQFSQWLKMVTLPTVWLGTASLAWELLIALWRWIQVQGWSRKFFAGIQLSVLGTATVFLFLISLVPYSYVEPGTHGRLWTGAHRLFSSVEHLQLANSYGLFRRMTGLGGRPEVVLEGSHDGHHWTEIEFMYKPGNVSRPPPFLIPHQPRLDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLIQNQVANYPFREQPPTYLRAQRYKYWFSKPGDQSRWWHRQWVEEFFPSVSLGDPTLETLLQQFGLKDKSPPRARSSKNALAQTLNWVRAQLSPLEPSILLWGLLGAVVAIRVVRTLLTPRPLQSSKQTREEKRKQAPKKDSRAVSEQTAPNSNSNGSWAPRRKK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:315218", 
            "resource": "KEGG Pathway", 
            "id": "rno:315218", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8963889", 
            "resource": "Reactome", 
            "id": "R-RNO-8963889", 
            "name": "Assembly of active LPL and LIPC lipase complexes"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J9#function", 
            "annotation": "Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L1J9#function", 
                    "id": "A1L1J9", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9BU23-1", 
            "protein_name": "Lipase maturation factor 2; Transmembrane protein 153; Transmembrane protein 112B.", 
            "sequence": {
                "length": 707, 
                "sequence": "MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYGPEGILPARRTLRPQGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVALGALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRKEAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQVRGWLRKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLANSYGLFRRMTGLGGRPEVVLEGSYDGHHWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFHKQPPTYVRAQRYKYWFSQPGEQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANSTLAQALHWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPASQKDSGAASEQATAAPNPCSSSSRTTRRKK"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A1L1J9/", 
                    "id": "A1L1J9", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/11251", 
                    "id": "11251", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q8C3X8-1", 
            "protein_name": "Lipase maturation factor 2; Transmembrane protein 153; Transmembrane protein 112B.", 
            "sequence": {
                "length": 702, 
                "sequence": "MASSRVPQQLFLQGVAAVYLFAFASLYTQIPGLYGPEGILPARRTLRPQGKGLWQQLWETPTLLWEAPRLGLDTAQGLDLLTLLGTVLALGALLLNSLRHPFVYLLLWVAYRSAYQVGQVFLYFQWDSLLLETGFLAILVAPLRGPSKHKILQGRLAGALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPTWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLTAFYAQALLQVLIIITGNYNFFNLLTLVLTTALLDDRHLSAEPGLRCHKKMPTSWPKALLTALSLLLELTVYGLLAYGTVYYFGLEVDWQQHIILSKTTFTFHQFSQWLKTVTLPTVWLGTASLAWELLVVLWRWIQVQGWSRKFSAGIQLSVLGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGSVEHLQLANSYGLFRRMTGVGGRPEVVLEGSYDGQHWTEIEFMYKPGNVSRPPPFLTPHQPRLDWQMWFAALGPHTHSPWFTGLVLRLLQGKEPVIRLVQSHVANYPFHERPPTYLRAQRYKYWFSKPGDQSRWWHRQWVEEFFPSVSLGDPTLETLLQQFGLKDKSPPRARSPSNGLAQTLNWVRTQLSPLEPPILLWGLFGAVVAIRVVQTLLAPRPLQSSKQTREEKRKQTSKKDSRAASEQAAANSNSRDSWAPRRKK"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A1L1J9/", 
                    "id": "A1L1J9", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/11251", 
                    "id": "11251", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073408.1", 
        "ac": "NP_001073408.1", 
        "name": "lipase maturation factor 2; transmembrane protein 112B.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J9", 
                                "id": "A1L1J9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J9", 
                                "id": "A1L1J9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J9", 
                                "id": "A1L1J9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein maturation", 
                        "id": "GO:0051604"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 490, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 488
        }, 
        {
            "end_pos": 695, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 693
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073408.1", 
            "id": "NP_001073408.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8963889", 
            "id": "R-RNO-8963889", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:315218", 
            "id": "rno:315218", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000030633", 
            "id": "ENSRNOG00000030633", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/YKPGNVN/", 
            "id": "YKPGNVN", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009613", 
            "id": "IPR009613", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF06762", 
            "id": "PF06762", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14463", 
            "id": "PTHR14463", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L1J9", 
            "id": "PR_A1L1J9", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/315218", 
            "id": "315218", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306274", 
            "id": "1306274", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1L1J9", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 80254.0, 
        "chemical_mass": 80254.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J9", 
            "name": "Lmf2; RGD1306274; Tmem112b.", 
            "locus": {
                "end_pos": 130322020, 
                "start_pos": 130326470, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000030633", 
                        "id": "ENSRNOG00000030633", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}