{ "uniprot_canonical_ac": "A1L1J7-1", "sequence": { "header": "tr|A1L1J7-1|A1L1J7_RAT Isoform 1 of PDZ-binding kinase OS=Rattus norvegicus OX=10116 GN=Pbk PE=1 SV=1 CANONICAL=A1L1J7-1", "length": 337, "sequence": "MEGISNFKTPNKLSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKINPLCDDHYRTVYQKRLTDEAKILKNLNHPNIVGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADMFAFGLTLWEMMTLCIPHINLPDDDDDEDATFDESDFDDEAYYAALGTRPSINMEELDESYQKVIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKHSLYGNC" }, "uniprot_id": "A1L1J7_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "lymphokine-activated killer T-cell-originated protein kinase" ], "uniprotkb": [ "PDZ-binding kinase" ] }, "gene": { "refseq": [ "Pbk" ], "uniprotkb": [ "Pbk" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "PDZ-binding kinase." }, "publication": [ { "title": "Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25065601", "journal": "The FEBS journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "id": "NP_001073406.1", "database": "RefSeq" } ], "authors": "Zhao H, Wang R, Tao Z, Yan F, Gao L, Liu X, Wang N, Min L, Jia Y, Zhao Y, Ji X, Luo Y", "date": "2014", "pmid": "25065601" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7/publications", "id": "A1L1J7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7#A1L1J7-1", "isoform_ac": "A1L1J7-1", "locus": { "end_pos": 42492367, "start_pos": 42499822, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000064306", "id": "ENSRNOT00000064306", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000061382", "id": "ENSRNOP00000061382", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A1L1J7-1|A1L1J7_RAT Isoform 1 of PDZ-binding kinase OS=Rattus norvegicus OX=10116 GN=Pbk PE=1 SV=1 CANONICAL=A1L1J7-1", "length": 337, "sequence": "MEGISNFKTPNKLSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKINPLCDDHYRTVYQKRLTDEAKILKNLNHPNIVGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADMFAFGLTLWEMMTLCIPHINLPDDDDDEDATFDESDFDDEAYYAALGTRPSINMEELDESYQKVIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKHSLYGNC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:290326", "resource": "KEGG Pathway", "id": "rno:290326", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "annotation": "TOPK confers neuroprotection against focal cerebral ischemia-reperfusion injury by antioxidative function.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "id": "NP_001073406.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9JJ78-1", "protein_name": "Lymphokine-activated killer T-cell-originated protein kinase; 2.7.12.2; T-LAK cell-originated protein kinase; PDZ-binding kinase.", "sequence": { "length": 330, "sequence": "MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1L1J7/", "id": "A1L1J7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/32415", "id": "32415", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96KB5-1", "protein_name": "Lymphokine-activated killer T-cell-originated protein kinase; 2.7.12.2; Spermatogenesis-related protein kinase; SPK; testis antigen 84; CT84; Nori-3; MAPKK-like protein kinase; T-LAK cell-originated protein kinase; PDZ-binding kinase.", "sequence": { "length": 322, "sequence": "MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32415", "id": "32415", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "ac": "NP_001073406.1", "name": "lymphokine-activated killer T-cell-originated protein kinase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "mitotic cell cycle", "id": "GO:0000278" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of inflammatory response", "id": "GO:0050728" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "cellular response to UV", "id": "GO:0034644" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032873", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of stress-activated MAPK cascade", "id": "GO:0032873" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 198, "annotation": "n_glycosylation_sequon", "start_pos": 196 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "id": "NP_001073406.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:290326", "id": "rno:290326", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015308", "id": "ENSRNOG00000015308", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/IPPSPML/", "id": "IPPSPML", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14001", "id": "cd14001", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034368", "id": "IPR034368", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041989", "id": "IPR041989", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43289:SF14", "id": "PTHR43289:SF14", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/290326", "id": "290326", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309565", "id": "1309565", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A1L1J7", "disease": [], "mass": { "monoisotopic_mass": 37570.0, "chemical_mass": 37570.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "name": "Pbk.", "locus": { "end_pos": 42500395, "start_pos": 42489377, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015308", "id": "ENSRNOG00000015308", "database": "Ensembl Gene" } ] } } ] }