{ "uniprot_canonical_ac": "A1L1I3-1", "sequence": { "header": "sp|A1L1I3-1|NUMBL_RAT Isoform 1 of Numb-like protein OS=Rattus norvegicus OX=10116 GN=Numbl PE=1 SV=1 CANONICAL=A1L1I3-1", "length": 614, "sequence": "MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL" }, "uniprot_id": "NUMBL_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "numb-like protein isoform X3" ], "uniprotkb": [ "Numb-like protein" ] }, "gene": { "refseq": [ "Numbl" ], "uniprotkb": [ "Numbl", "Nbl" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Numb-like protein." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3/publications", "id": "A1L1I3", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20079715", "journal": "Biochem. Biophys. Res. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3/publications", "id": "A1L1I3", "database": "UniProtKB" } ], "authors": "Ma Q., Zhou L., Huo K., Shi H.", "date": "2010", "pmid": "20079715" }, { "title": "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18299187", "journal": "Cell. Signal.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3/publications", "id": "A1L1I3", "database": "UniProtKB" } ], "authors": "Ma Q., Zhou L., Huo K., Shi H.", "date": "2008", "pmid": "18299187" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3#A1L1I3-1", "isoform_ac": "A1L1I3-1", "locus": { "end_pos": 84068048, "start_pos": 84090899, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000057213", "id": "ENSRNOT00000057213", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000054039", "id": "ENSRNOP00000054039", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1L1I3-1|NUMBL_RAT Isoform 1 of Numb-like protein OS=Rattus norvegicus OX=10116 GN=Numbl PE=1 SV=1 CANONICAL=A1L1I3-1", "length": 614, "sequence": "MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL" } }, { "url": "https://www.uniprot.org/uniprot/A1L1I3#A0A0G2K9C5-1", "isoform_ac": "A0A0G2K9C5-1", "locus": { "end_pos": 84071180, "start_pos": 84090899, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090478", "id": "ENSRNOT00000090478", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074945", "id": "ENSRNOP00000074945", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K9C5-1|NUMBL_RAT Computationally mapped isoform of Numb-like protein OS=Rattus norvegicus OX=10116 GN=Numbl PE=1 SV=1 CANONICAL=A1L1I3-1", "length": 641, "sequence": "MTTRFPTREPEMEGAEEGTKSPAPTNFSLSHSLEQGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3#function", "annotation": "Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3#function", "id": "A1L1I3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9Y6R0-1", "protein_name": "Numb-like protein; Numb-related protein; Numb-R.", "sequence": { "length": 609, "sequence": "MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68413", "id": "68413", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "O08919-1", "protein_name": "Numb-like protein.", "sequence": { "length": 604, "sequence": "MSRSAAASGGPRRPDQHLSPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGINALCTQISSSFASAGAPASGPPPATTGTSAWGEPSVPAAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSAPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68413", "id": "68413", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006228629.1", "ac": "XP_006228629.1", "name": "numb-like protein isoform X3.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "cadherin binding", "id": "GO:0045296" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050775", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "positive regulation of dendrite morphogenesis", "id": "GO:0050775" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021670", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "lateral ventricle development", "id": "GO:0021670" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "cytokine-mediated signaling pathway", "id": "GO:0019221" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050769", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "positive regulation of neurogenesis", "id": "GO:0050769" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019538", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "protein metabolic process", "id": "GO:0019538" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021849", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "id": "A1L1I3", "database": "UniProtKB" } ], "name": "neuroblast division in subventricular zone", "id": "GO:0021849" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006228629.1", "id": "XP_006228629.1", "database": "RefSeq" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020867", "id": "ENSRNOG00000020867", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "id": "IPR006020", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010449", "id": "IPR010449", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016698", "id": "IPR016698", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00640", "id": "PF00640", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06311", "id": "PF06311", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L1I3", "id": "PR_A1L1I3", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/292732", "id": "292732", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307579", "id": "1307579", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A1L1I3", "disease": [], "mass": { "monoisotopic_mass": 65513.0, "chemical_mass": 65513.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1L1I3", "name": "Numbl; Nbl.", "locus": { "end_pos": 84091671, "start_pos": 84067938, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020867", "id": "ENSRNOG00000020867", "database": "Ensembl Gene" } ] } } ] }