{
    "uniprot_canonical_ac": "A1L157-1", 
    "sequence": {
        "header": "sp|A1L157-1|TSN11_HUMAN Isoform 1 of Tetraspanin-11  OS=Homo sapiens OX=9606 GN=TSPAN11 PE=2 SV=2 CANONICAL=A1L157-1", 
        "length": 253, 
        "sequence": "MAHYKTEQDDWLIIYLKYLLFVFNFFFWVGGAAVLAVGIWTLVEKSGYLSVLASSTFAASAYILIFAGVLVMVTGFLGFGAILWERKGCLSTYFCLLLVIFLVELVAGVLAHVYYQRLSDELKQHLNRTLAENYGQPGATQITASVDRLQQDFKCCGSNSSADWQHSTYILLREAEGRQVPDSCCKTVVVRCGQRAHPSNIYKVEGGCLTKLEQFLADHLLLMGAVGIGVACLQICGMVLTCCLHQRLQRHFY"
    }, 
    "uniprot_id": "TSN11_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "tetraspanin-11 isoform 1", 
                "tspan-11"
            ], 
            "uniprotkb": [
                "Tetraspanin-11", 
                "Tspan-11"
            ]
        }, 
        "gene": {
            "refseq": [
                "TSPAN11", 
                "VSSW1971"
            ], 
            "uniprotkb": [
                "TSPAN11", 
                "VSSW1971"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L157", 
                    "id": "A1L157", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Tetraspanin-11; Tspan-11.", 
        "short": "Tspan-11"
    }, 
    "publication": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L157", 
                    "id": "A1L157", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 127, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutation": [
        {
            "start_pos": 229, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (2/5): patient freq. (1.1%); num. of cancers (4). In dbSNP: rs140179345.", 
            "sequence_org": "G", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "93", 
            "end_pos": 229, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 229, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs140179345.", 
            "sequence_org": "G", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "1144", 
            "end_pos": 229, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 184, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "C", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "50", 
            "end_pos": 184, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 106, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "V", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "50", 
            "end_pos": 106, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 99, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "V", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "50", 
            "end_pos": 99, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 229, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs140179345.", 
            "sequence_org": "G", 
            "disease": {
                "doid": "10534", 
                "url": "http://disease-ontology.org/term/DOID:10534", 
                "icd10": "", 
                "name": "Stomach cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "1044", 
            "end_pos": 229, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 229, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.2", 
            "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs140179345.", 
            "sequence_org": "G", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "Liver cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "412", 
            "end_pos": 229, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 179, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "Q", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "50", 
            "end_pos": 179, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L157#A1L157-1", 
            "isoform_ac": "A1L157-1", 
            "locus": {
                "end_pos": 30953992, 
                "start_pos": 30991912, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000261177", 
                        "id": "ENST00000261177", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000261177", 
                        "id": "ENSP00000261177", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1L157-1|TSN11_HUMAN Isoform 1 of Tetraspanin-11  OS=Homo sapiens OX=9606 GN=TSPAN11 PE=2 SV=2 CANONICAL=A1L157-1", 
                "length": 253, 
                "sequence": "MAHYKTEQDDWLIIYLKYLLFVFNFFFWVGGAAVLAVGIWTLVEKSGYLSVLASSTFAASAYILIFAGVLVMVTGFLGFGAILWERKGCLSTYFCLLLVIFLVELVAGVLAHVYYQRLSDELKQHLNRTLAENYGQPGATQITASVDRLQQDFKCCGSNSSADWQHSTYILLREAEGRQVPDSCCKTVVVRCGQRAHPSNIYKVEGGCLTKLEQFLADHLLLMGAVGIGVACLQICGMVLTCCLHQRLQRHFY"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L157#F5H195-1", 
            "isoform_ac": "F5H195-1", 
            "locus": {
                "end_pos": 30953992, 
                "start_pos": 30954114, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000545802", 
                        "id": "ENST00000545802", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000443890", 
                        "id": "ENSP00000443890", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F5H195-1|TSN11_HUMAN Computationally mapped isoform of Tetraspanin-11  OS=Homo sapiens OX=9606 GN=TSPAN11 PE=2 SV=1 CANONICAL=A1L157-1", 
                "length": 41, 
                "sequence": "MAHYKTEQDDWLIIYLKYLLFVFNFFFWVSEFCTHILFPEH"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L157#F5H2P0-1", 
            "isoform_ac": "F5H2P0-1", 
            "locus": {
                "end_pos": 30963955, 
                "start_pos": 30991912, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000535215", 
                        "id": "ENST00000535215", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000445503", 
                        "id": "ENSP00000445503", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F5H2P0-1|TSN11_HUMAN Computationally mapped isoform of Tetraspanin-11  OS=Homo sapiens OX=9606 GN=TSPAN11 PE=2 SV=1 CANONICAL=A1L157-1", 
                "length": 182, 
                "sequence": "MVTGFLGFGAILWERKGCLSTYFCLLLVIFLVELVAGVLAHVYYQRLSDELKQHLNRTLAENYGQPGATQITASVDRLQQDFKCCGSNSSADWQHSTYILLREAEGRQVPDSCCKTVVVRCGQRAHPSNIYKVEGGCLTKLEQFLADHLLLMGAVGIGVACLQICGMVLTCCLHQRLQRHFY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:441631", 
            "resource": "KEGG Pathway", 
            "id": "hsa:441631", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9D1D1-1", 
            "protein_name": "Tetraspanin-11; Tspan-11.", 
            "sequence": {
                "length": 253, 
                "sequence": "MAHCKTEQDDWLLAHLKYLLFIFNFFFWVGGAAVMAVGIWTLVEKSGYLSILASSTFAASAYILIFVGGLVMTTGFLGFGAIIREQKSCLSTYFCLLLVIFLVELVAGVLAHVYYQRLSDELKWHLNSTLTEHYGQPRAAEITASVDRLQQDFKCCGSNSSADWQHSAYILSQEALGRQVPDSCCKTVVARCGQRAHPSNIYKVEGGCMAKLEQFVADHLLLMGAVGIGVACLQICGMVLTCCLHRRLQQQFY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/23595", 
                    "id": "23595", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q568Y5-1", 
            "protein_name": "Tetraspanin-11; Tspan-11.", 
            "sequence": {
                "length": 253, 
                "sequence": "MAHCKTEQDDWLLAHLKYLLFIFNFFFWVGGAAVMAVGIWTLVEKSVYLSILASSTFAASAYVLIFVGGLVMTTGFLGFGAIIREQKSCLSTYFCLLLAIFLVELVAGVLAHVYYQRLSDELKRHLHSTLTEHYGQPGAAEITASVDRLQQDFKCCGSNSSADWQHSVYILSQEAIGRQVPDSCCKTVVARCGQRAHPSNIYKVEGGCMAKLEQFLADHLLLMGAVGIGVACLQICGMVLTCCLHRRLQQHFY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/23595", 
                    "id": "23595", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073978.1", 
        "ac": "NP_001073978.1", 
        "name": "tetraspanin-11 isoform 1; tspan-11.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L157", 
                                "id": "A1L157", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of plasma membrane", 
                        "id": "GO:0005887"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L157", 
                                "id": "A1L157", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell migration", 
                        "id": "GO:0016477"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 129, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 127
        }, 
        {
            "end_pos": 161, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 159
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073978.1", 
            "id": "NP_001073978.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30795", 
            "id": "30795", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A1L157", 
            "id": "A1L157", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A1L157", 
            "id": "NX_A1L157", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TSPAN11", 
            "id": "TSPAN11", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:441631", 
            "id": "hsa:441631", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000110900", 
            "id": "ENSG00000110900", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KSCLSTY/", 
            "id": "KSCLSTY", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", 
            "id": "IPR000301", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", 
            "id": "IPR008952", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", 
            "id": "IPR018499", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00335", 
            "id": "PF00335", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L157", 
            "id": "PR_A1L157", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A1L157*", 
            "id": "A1L157", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/441631", 
            "id": "441631", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L157", 
                    "id": "A1L157", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A1L157", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 28245.0, 
        "chemical_mass": 28245.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000110900", 
                    "id": "ENSG00000110900", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000110900", 
                    "id": "ENSG00000110900", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
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    "gene": [
        {
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        }
    ]
}