{
    "uniprot_canonical_ac": "A1L131-1", 
    "sequence": {
        "header": "sp|A1L131-1|CUED2_RAT Isoform 1 of CUE domain-containing protein 2  OS=Rattus norvegicus OX=10116 GN=Cuedc2 PE=2 SV=1 CANONICAL=A1L131-1", 
        "length": 267, 
        "sequence": "MELERIVSSALFAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFIEMMEAYVPGFAHIHRGIIEDMVQTLSVQLSSARNKETLRRPEKLKEESRPPAATGNTQDEAAAAEEEQPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGKEEGPPGWGGPNQDLPRRLRGPRKEELKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPETEEMKATYINLKPARKYRFH"
    }, 
    "uniprot_id": "CUED2_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "CUE domain-containing protein 2"
            ], 
            "uniprotkb": [
                "CUE domain-containing protein 2"
            ]
        }, 
        "gene": {
            "refseq": [
                "Cuedc2"
            ], 
            "uniprotkb": [
                "Cuedc2"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L131", 
                    "id": "A1L131", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "CUE domain-containing protein 2."
    }, 
    "publication": [
        {
            "title": "Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24882011", 
            "journal": "Cell reports", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073355.1", 
                    "id": "NP_001073355.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Chen Y, Wang SX, Mu R, Luo X, Liu ZS, Liang B, Zhuo HL, Hao XP, Wang Q, Fang DF, Bai ZF, Wang QY, Wang HM, Jin BF, Gong WL, Zhou T, Zhang XM, Xia Q, Li T", 
            "date": "2014", 
            "pmid": "24882011"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L131#A1L131-1", 
            "isoform_ac": "A1L131-1", 
            "locus": {
                "end_pos": 266078264, 
                "start_pos": 266080259, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000026609", 
                        "id": "ENSRNOT00000026609", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000026609", 
                        "id": "ENSRNOP00000026609", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1L131-1|CUED2_RAT Isoform 1 of CUE domain-containing protein 2  OS=Rattus norvegicus OX=10116 GN=Cuedc2 PE=2 SV=1 CANONICAL=A1L131-1", 
                "length": 267, 
                "sequence": "MELERIVSSALFAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFIEMMEAYVPGFAHIHRGIIEDMVQTLSVQLSSARNKETLRRPEKLKEESRPPAATGNTQDEAAAAEEEQPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGKEEGPPGWGGPNQDLPRRLRGPRKEELKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPETEEMKATYINLKPARKYRFH"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:294009", 
            "resource": "KEGG Pathway", 
            "id": "rno:294009", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L131#function", 
            "annotation": "Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L131#function", 
                    "id": "A1L131", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9CXX9-1", 
            "protein_name": "CUE domain-containing protein 2.", 
            "sequence": {
                "length": 284, 
                "sequence": "MELERIVGSALLTFVQAHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGIIGDMMQKLSVQLSDARNKENLHPQSSCVQGQVPIFPETPRQAEKLEEESRPPAAPGNTLDEAAAAEELPGVDVLLEVFPTCSMEQAQWVLAKARGDLEEAVHMLVEGKEEGPPGWDGPSQDLPRRLRGPQKDDLKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A1L131/", 
                    "id": "A1L131", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/11430", 
                    "id": "11430", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9H467-1", 
            "protein_name": "CUE domain-containing protein 2.", 
            "sequence": {
                "length": 287, 
                "sequence": "MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/11430", 
                    "id": "11430", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073355.1", 
        "ac": "NP_001073355.1", 
        "name": "CUE domain-containing protein 2.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L131", 
                                "id": "A1L131", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L131", 
                                "id": "A1L131", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L131", 
                                "id": "A1L131", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear membrane", 
                        "id": "GO:0031965"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900016", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L131", 
                                "id": "A1L131", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cytokine production involved in inflammatory response", 
                        "id": "GO:1900016"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010936", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L131", 
                                "id": "A1L131", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of macrophage cytokine production", 
                        "id": "GO:0010936"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073355.1", 
            "id": "NP_001073355.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:294009", 
            "id": "rno:294009", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019574", 
            "id": "ENSRNOG00000019574", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EMFPACT/", 
            "id": "EMFPACT", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14367", 
            "id": "cd14367", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", 
            "id": "IPR003892", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039784", 
            "id": "IPR039784", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039805", 
            "id": "IPR039805", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12493", 
            "id": "PTHR12493", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L131", 
            "id": "PR_A1L131", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/294009", 
            "id": "294009", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308096", 
            "id": "1308096", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1L131", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 30282.0, 
        "chemical_mass": 30282.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L131", 
            "name": "Cuedc2.", 
            "locus": {
                "end_pos": 266078108, 
                "start_pos": 266086299, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019574", 
                        "id": "ENSRNOG00000019574", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}