{
    "uniprot_canonical_ac": "A1EGX6-1", 
    "sequence": {
        "header": "sp|A1EGX6-1|FSCB_MOUSE Isoform 1 of Fibrous sheath CABYR-binding protein  OS=Mus musculus OX=10090 GN=Fscb PE=1 SV=1 CANONICAL=A1EGX6-1", 
        "length": 1074, 
        "sequence": "MEECEEPEEPISLGRQEYRRRRRPSQPMVDKSQQTEITEKRKAMASVQPPAPKATHSIGNIPGSKDNYSRKEYESLRLSSQLQKTLMKRKHVQDMTDKSLQTEPIVEEKVEVIFIDKTLKLEENTAGVGEIAPELPQSIPEVEIPTSRPTSHLIDRSQQTSCTGDWSLIYICPKEKVDKEQQTYFSELEIIIRSIPGSSMTKSKEETIPIAQEDPLVEINGSLEIEVLSPEELPDVMMSFTEGEISGELQALSNGEATVKGELFLTEEIPIQAPSPAEETSAAETATTTAKDVVDIQAPPADKLSSVEAPADISPTLVQGALSDKPSDQQYPQGTEMAPSELPVEDLDPFSEEVLEKVQALTTDSMLEDLGIAESTIAEETSGKVQHPLSEETSKEVPAEVHFPIAADFEESAILINEKFATDEVFEEYKPPIIEEVSADKATAEVQPPSAEDASEEVASSEVLPPSTEQGTVEDLTAEVLSTPTEEGPTEVPPQPTEEGPAEVPPPLSEEGPAEVPPAPAEEAPAEVLPPPAEEAPAEVPPPLTEEGPAEVPPPLTEEGPAEVPLAPAEEVPAEFLPPPAEEVPAEVPPPLTEEGPAEVPPPLTEEGPEEVPPLPAEEAPTKVPPSPAEKGSAEVSPPQTEEGPAEVPPPPAEEFPTEVPSSSAEEGSSEVPLPPTAERPEEAPPPATEEAPVEVLPPATEEAPVEVLPPATEEAPVEVQSPAAEEGLAEVPPPPTEESPTHDVPTEVQVPQAKESPGQVLPLSGESTAEEASAQVQPPSFEKAPLESLPLEEVEKIHLDNLPFEVQPLPTEDIAIGVPAESQALPADENPAREDTVETQPSSFEGAPIAENPIEAPLPASEADTGREDSAVHPSSLGPTDEAPAEIQILQTDDIPTEMSPVENQPLPAEEGFPEVVSEEEATAAEVRFPLSEGAPAQEATVEAQLTSVEESPKRASVDVQPLSPETPVEESPGVDLPLKTNEVTMQEFRVEKMPAEDSLPPSEQTPADQVLLKEHRLSQVADISEKELESTTLTSDKMSEGIDSVPEDVSGTKDDQISTFKIEGTIKIELKN"
    }, 
    "uniprot_id": "FSCB_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Fibrous sheath CABYR-binding protein", 
                "PKA-phosphorylated calcium and CABYR-binding protein"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "Fscb"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EGX6", 
                    "id": "A1EGX6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Fibrous sheath CABYR-binding protein; PKA-phosphorylated calcium and CABYR-binding protein."
    }, 
    "publication": [
        {
            "title": "FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/27398160", 
            "journal": "Am. J. Transl. Res.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EGX6/publications", 
                    "id": "A1EGX6", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Liu B., Liu S., Zhang X., Chen M., Yu R., Tian Z.", 
            "date": "2016", 
            "pmid": "27398160"
        }, 
        {
            "title": "FSCB phosphorylation in mouse spermatozoa capacitation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21871179", 
            "journal": "BMB Rep.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EGX6/publications", 
                    "id": "A1EGX6", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Tang J., Zhang J., Zheng Y.H., Tian Y., Wang X.W., Li Y.F., Liu S.L., Ni B., Huang Z.M., Huo W.Q., Jin F.S., Tian Z.Q.", 
            "date": "2011", 
            "pmid": "21871179"
        }, 
        {
            "title": "FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17855365", 
            "journal": "J. Biol. Chem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EGX6/publications", 
                    "id": "A1EGX6", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Herr J.C., Kim Y.-H., Mandal A., He W., Flickinger C.J., Klotz K., Jha K.N., Li Y.-F., Digilio L., Pulido S.", 
            "date": "2007", 
            "pmid": "17855365"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EGX6#A1EGX6-1", 
            "isoform_ac": "A1EGX6-1", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A1EGX6-1|FSCB_MOUSE Isoform 1 of Fibrous sheath CABYR-binding protein  OS=Mus musculus OX=10090 GN=Fscb PE=1 SV=1 CANONICAL=A1EGX6-1", 
                "length": 1074, 
                "sequence": "MEECEEPEEPISLGRQEYRRRRRPSQPMVDKSQQTEITEKRKAMASVQPPAPKATHSIGNIPGSKDNYSRKEYESLRLSSQLQKTLMKRKHVQDMTDKSLQTEPIVEEKVEVIFIDKTLKLEENTAGVGEIAPELPQSIPEVEIPTSRPTSHLIDRSQQTSCTGDWSLIYICPKEKVDKEQQTYFSELEIIIRSIPGSSMTKSKEETIPIAQEDPLVEINGSLEIEVLSPEELPDVMMSFTEGEISGELQALSNGEATVKGELFLTEEIPIQAPSPAEETSAAETATTTAKDVVDIQAPPADKLSSVEAPADISPTLVQGALSDKPSDQQYPQGTEMAPSELPVEDLDPFSEEVLEKVQALTTDSMLEDLGIAESTIAEETSGKVQHPLSEETSKEVPAEVHFPIAADFEESAILINEKFATDEVFEEYKPPIIEEVSADKATAEVQPPSAEDASEEVASSEVLPPSTEQGTVEDLTAEVLSTPTEEGPTEVPPQPTEEGPAEVPPPLSEEGPAEVPPAPAEEAPAEVLPPPAEEAPAEVPPPLTEEGPAEVPPPLTEEGPAEVPLAPAEEVPAEFLPPPAEEVPAEVPPPLTEEGPAEVPPPLTEEGPEEVPPLPAEEAPTKVPPSPAEKGSAEVSPPQTEEGPAEVPPPPAEEFPTEVPSSSAEEGSSEVPLPPTAERPEEAPPPATEEAPVEVLPPATEEAPVEVLPPATEEAPVEVQSPAAEEGLAEVPPPPTEESPTHDVPTEVQVPQAKESPGQVLPLSGESTAEEASAQVQPPSFEKAPLESLPLEEVEKIHLDNLPFEVQPLPTEDIAIGVPAESQALPADENPAREDTVETQPSSFEGAPIAENPIEAPLPASEADTGREDSAVHPSSLGPTDEAPAEIQILQTDDIPTEMSPVENQPLPAEEGFPEVVSEEEATAAEVRFPLSEGAPAQEATVEAQLTSVEESPKRASVDVQPLSPETPVEESPGVDLPLKTNEVTMQEFRVEKMPAEDSLPPSEQTPADQVLLKEHRLSQVADISEKELESTTLTSDKMSEGIDSVPEDVSGTKDDQISTFKIEGTIKIELKN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1EGX6#E9QJV1-1", 
            "isoform_ac": "E9QJV1-1", 
            "locus": {
                "end_pos": 64471505, 
                "start_pos": 64474690, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000059833", 
                        "id": "ENSMUST00000059833", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000051554", 
                        "id": "ENSMUSP00000051554", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E9QJV1-1|FSCB_MOUSE Computationally mapped isoform of Fibrous sheath CABYR-binding protein  OS=Mus musculus OX=10090 GN=Fscb PE=1 SV=1 CANONICAL=A1EGX6-1", 
                "length": 1062, 
                "sequence": "MEECEEPEEPISLGRQEYRRRRRPSQPMVDKSQQTEITEKRKAMASVQPPAPKATHSIGNIPGSKDNYSRKEYESLRLSSQLQKTLMKRKHVQDMTDKSLQTEPIVEEKVEVIFIDKTLKLEENTAGVGEIAPELPQSIPEVEIPTSRPTSHLIDRSQQTSCTGDWSLIYICPKEKVDKEQQTYFSELEIIIRSIPGSSMTKSKEETIPIAQEDPLVEINGSLEIEVLSPEELPDVMMSFTEGEISGELQALSNGEATVKGELFLTEEIPIQAPSPAEETSAAETATTTAKDVVDIQAPPADKLSSVEAPADISPTLVQGALSDKPSDQQYPQGTEMAPSELPVEDLDPFSEEVLEKVQALTTDSMLEDLGIAESTIAEETSGKVQHPLSEETSKEVPAEVHFPIAADFEESAILINEKFATDEVFEEYKPPIIEEVSADKATAEVQPPSAEDASEEVAPSEVLPPSTEQGTVEDLTAEVLSTPTEEGPTEVPPQPTEEGPAEVPPPLSEEGPAEVPPAPAEEAPAEVLPPPAEEAPAEVPPPLTEEGPAEVPPTLTEEGPAEVPLAPAEEVPAEVLPPPAEEVPAEVPPPLTEEGPAEVPPPLTEEGPEEVPPLPAEEAPTKVPPSPAEKGSAEVSPPQTEEGPAEVPPPPAEEFPTEVPSSSAEEGSSEVPLPPTAERPEEAPPPATEEAPVEVLPPATEEAPVEVQSPAAEEGLAEVPPPPTEESPTHDVPTEVQVPQAKESPGQVLPLSGESTAEEASAQVQPPSFEKAPLESLPLEEVEKIHLDNLPFEVQPLPTEDIAIGVPAESQALPADENPAREDTVETQPSSFEGAPIAENPIEAPLPASEADTGREDSAVHPSSLAPTDEAPAEIQILQTDDIPTEMSPVENQPLPAEEGFPEVVSEEEATAAEVRFPLSEGAPAQEATVEAQLTSVEESPKRASVDVQPLSPETPVEESPGVDLPLKTNEVTMQEFRVEKMPAEDPLPPSEQTPADQVLLKEHRLSQVADISEKELESTTLTSDKMSEGIDSVPEDVSGTKDDQISTFKIEGTIKIELKN"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EGX6#function", 
            "annotation": "May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EGX6#function", 
                    "id": "A1EGX6", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EGX6", 
                                "id": "A1EGX6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "calcium ion binding", 
                        "id": "GO:0005509"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035686", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EGX6", 
                                "id": "A1EGX6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sperm fibrous sheath", 
                        "id": "GO:0035686"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EGX6", 
                                "id": "A1EGX6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sperm principal piece", 
                        "id": "GO:0097228"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033234", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EGX6", 
                                "id": "A1EGX6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of protein sumoylation", 
                        "id": "GO:0033234"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 69, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 67
        }, 
        {
            "end_pos": 222, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 220
        }
    ], 
    "crossref": [
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1EGX6", 
            "id": "PR_A1EGX6", 
            "database": "PRO"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3646964", 
            "id": "3646964", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1EGX6", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 114979.0, 
        "chemical_mass": 114979.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EGX6", 
            "name": "Fscb.", 
            "locus": {
                "end_pos": 64471330, 
                "start_pos": 64474690, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000043060", 
                        "id": "ENSMUSG00000043060", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}