{
    "uniprot_canonical_ac": "A1A5S3-1", 
    "sequence": {
        "header": "sp|A1A5S3-1|GPR18_RAT Isoform 1 of N-arachidonyl glycine receptor  OS=Rattus norvegicus OX=10116 GN=Gpr18 PE=1 SV=1 CANONICAL=A1A5S3-1", 
        "length": 331, 
        "sequence": "MAIPSNRDQLALSNGSHPEEYKIAALVFYSCIFLIGLLVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGDYFCHILGALVVFYPSLALWLLALISADRYMAIVQPKYAKELKNTGKAVLACVGVWIMTLTTTVPLLLLDEDPDKASSPATCLKISDIIHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIVTLLLQVLACFVPFHICFALLMLQGEENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML"
    }, 
    "uniprot_id": "GPR18_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "N-arachidonyl glycine receptor", 
                "NAGly receptor"
            ], 
            "uniprotkb": [
                "N-arachidonyl glycine receptor", 
                "NAGly receptor", 
                "G-protein coupled receptor 18"
            ]
        }, 
        "gene": {
            "refseq": [
                "Gpr18"
            ], 
            "uniprotkb": [
                "Gpr18"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                    "id": "A1A5S3", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "N-arachidonyl glycine receptor; NAGly receptor; G-protein coupled receptor 18.", 
        "short": "NAGly receptor"
    }, 
    "publication": [
        {
            "title": "The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24431468", 
            "journal": "The Journal of pharmacology and experimental therapeutics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178.1", 
                    "id": "NP_001073178.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5S3/publications", 
                    "id": "A1A5S3", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Penumarti A, Abdel-Rahman AA", 
            "date": "2014", 
            "pmid": "24431468"
        }, 
        {
            "title": "GPR18 is required for a normal CD8alphaalpha intestinal intraepithelial lymphocyte compartment.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/25348153", 
            "journal": "The Journal of experimental medicine", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178.1", 
                    "id": "NP_001073178.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang X, Sumida H, Cyster JG", 
            "date": "2014", 
            "pmid": "25348153"
        }
    ], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                    "id": "A1A5S3", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 14, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                    "id": "A1A5S3", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 188, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A5S3#A1A5S3-1", 
            "isoform_ac": "A1A5S3-1", 
            "locus": {
                "end_pos": 108323276, 
                "start_pos": 108324268, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000016848", 
                        "id": "ENSRNOT00000016848", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000016848", 
                        "id": "ENSRNOP00000016848", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1A5S3-1|GPR18_RAT Isoform 1 of N-arachidonyl glycine receptor  OS=Rattus norvegicus OX=10116 GN=Gpr18 PE=1 SV=1 CANONICAL=A1A5S3-1", 
                "length": 331, 
                "sequence": "MAIPSNRDQLALSNGSHPEEYKIAALVFYSCIFLIGLLVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGDYFCHILGALVVFYPSLALWLLALISADRYMAIVQPKYAKELKNTGKAVLACVGVWIMTLTTTVPLLLLDEDPDKASSPATCLKISDIIHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIVTLLLQVLACFVPFHICFALLMLQGEENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:679957", 
            "resource": "KEGG Pathway", 
            "id": "rno:679957", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", 
            "resource": "Reactome", 
            "id": "R-RNO-418594", 
            "name": "G alpha (i) signalling events"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-373076", 
            "resource": "Reactome", 
            "id": "R-RNO-373076", 
            "name": "Class A/1 (Rhodopsin-like receptors)"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A5S3#function", 
            "annotation": "Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:24431468). However, conflicting results about the role of NAGly as an agonist are reported (By similarity). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24431468). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity). May contribute to regulation of the immune system (By similarity). Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (PubMed:24431468). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5S3#function", 
                    "id": "A1A5S3", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178.1", 
            "annotation": "The role of a novel cannabinoid receptor GPR18, espressed in the rostral ventrolateral medulla, in central blood pressure control.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178.1", 
                    "id": "NP_001073178.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q14330-1", 
            "protein_name": "N-arachidonyl glycine receptor; NAGly receptor; G-protein coupled receptor 18.", 
            "sequence": {
                "length": 331, 
                "sequence": "MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/18814", 
                    "id": "18814", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q8K1Z6-1", 
            "protein_name": "N-arachidonyl glycine receptor; NAGly receptor; G-protein coupled receptor 18.", 
            "sequence": {
                "length": 331, 
                "sequence": "MATLSNHNQLDLSNGSHPEEYKIAALVFYSCIFLIGLFVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGEYFCHILGALVVFYPSLALWLLAFISADRYMAIVQPKYAKELKNTGKAVLACGGVWVMTLTTTVPLLLLYEDPDKASSPATCLKISDITHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIMTLLLQVLVCFVPFHICFAVLMLQGQENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/18814", 
                    "id": "18814", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1A5S3/", 
                    "id": "A1A5S3", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178.1", 
        "ac": "NP_001073178.1", 
        "name": "N-arachidonyl glycine receptor; NAGly receptor.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "G protein-coupled receptor activity", 
                        "id": "GO:0004930"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of plasma membrane", 
                        "id": "GO:0005887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasmic vesicle membrane", 
                        "id": "GO:0030659"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051482", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway", 
                        "id": "GO:0051482"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035025", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of Rho protein signal transduction", 
                        "id": "GO:0035025"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002300", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "CD8-positive, alpha-beta intraepithelial T cell differentiation", 
                        "id": "GO:0002300"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002689", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of leukocyte chemotaxis", 
                        "id": "GO:0002689"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of tumor necrosis factor production", 
                        "id": "GO:0032720"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002305", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5S3", 
                                "id": "A1A5S3", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "CD8-positive, gamma-delta intraepithelial T cell differentiation", 
                        "id": "GO:0002305"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 16, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 14
        }, 
        {
            "end_pos": 42, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 40
        }, 
        {
            "end_pos": 190, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 188
        }, 
        {
            "end_pos": 278, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 276
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178.1", 
            "id": "NP_001073178.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", 
            "id": "R-RNO-418594", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-373076", 
            "id": "R-RNO-373076", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:679957", 
            "id": "rno:679957", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012628", 
            "id": "ENSRNOG00000012628", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DLIFIMS/", 
            "id": "DLIFIMS", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028335", 
            "id": "IPR028335", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", 
            "id": "IPR000276", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", 
            "id": "IPR017452", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00001", 
            "id": "PF00001", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24232:SF1", 
            "id": "PTHR24232:SF1", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A5S3", 
            "id": "PR_A1A5S3", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/679957", 
            "id": "679957", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304889", 
            "id": "1304889", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1A5S3", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 37556.0, 
        "chemical_mass": 37556.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A5S3", 
            "name": "Gpr18.", 
            "locus": {
                "end_pos": 108323179, 
                "start_pos": 108326907, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000012628", 
                        "id": "ENSRNOG00000012628", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}