{ "uniprot_canonical_ac": "A1A5R1-1", "sequence": { "header": "sp|A1A5R1-1|RFOX2_RAT Isoform 1 of RNA binding protein fox-1 homolog 2 OS=Rattus norvegicus OX=10116 GN=Rbfox2 PE=2 SV=1 CANONICAL=A1A5R1-1", "length": 432, "sequence": "MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADEGMQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSSQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY" }, "uniprot_id": "RFOX2_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "RNA binding protein fox-1 homolog 2", "RNA-binding protein 9; fox-1 homolog B; RNA-binding motif protein 9; RNA-binding protein FOX2; RNA binding protein, fox-1 homolog 2" ], "uniprotkb": [ "RNA binding protein fox-1 homolog 2", "RNA-binding protein 9", "Fox-1 homolog B", "RNA-binding motif protein 9" ] }, "gene": { "refseq": [ "Rbfox2", "Rbm9" ], "uniprotkb": [ "Rbfox2", "Fox2", "Rbm9" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "RNA binding protein fox-1 homolog 2; RNA-binding protein 9; Fox-1 homolog B; RNA-binding motif protein 9." }, "publication": [ { "title": "Novel Rbfox2 isoforms associated with alternative exon usage in rat cortex and suprachiasmatic nucleus.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28855650", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Partridge LMM, Carter DA", "date": "2017", "pmid": "28855650" }, { "title": "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22658674", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW", "date": "2012", "pmid": "22658674" }, { "title": "The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22357600", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M Jr, Otis TS, Black DL", "date": "2012", "pmid": "22357600" }, { "title": "Fox-3 and PSF interact to activate neural cell-specific alternative splicing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21177649", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Kim KK, Kim YC, Adelstein RS, Kawamoto S", "date": "2011", "pmid": "21177649" }, { "title": "Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18381283", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Wolfrum C, Howell JJ, Ndungo E, Stoffel M", "date": "2008", "pmid": "18381283" }, { "title": "Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17715393", "journal": "Blood", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Yang G, Huang SC, Wu JY, Benz EJ Jr", "date": "2008", "pmid": "17715393" }, { "title": "A negative coregulator for the human ER.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11875103", "journal": "Molecular endocrinology (Baltimore, Md.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ], "authors": "Norris JD, Fan D, Sherk A, McDonnell DP", "date": "2002", "pmid": "11875103" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1#A1A5R1-1", "isoform_ac": "A1A5R1-1", "locus": { "end_pos": 118157265, "start_pos": 118396257, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066431", "id": "ENSRNOT00000066431", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000063462", "id": "ENSRNOP00000063462", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A5R1-1|RFOX2_RAT Isoform 1 of RNA binding protein fox-1 homolog 2 OS=Rattus norvegicus OX=10116 GN=Rbfox2 PE=2 SV=1 CANONICAL=A1A5R1-1", "length": 432, "sequence": "MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADEGMQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSSQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY" } }, { "url": "https://www.uniprot.org/uniprot/A1A5R1#A0A0G2JYY7-1", "isoform_ac": "A0A0G2JYY7-1", "locus": { "end_pos": 118157265, "start_pos": 118332385, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090370", "id": "ENSRNOT00000090370", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070842", "id": "ENSRNOP00000070842", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JYY7-1|RFOX2_RAT Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Rattus norvegicus OX=10116 GN=Rbfox2 PE=2 SV=1 CANONICAL=A1A5R1-1", "length": 400, "sequence": "MSSDSMDQPRNPCENEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSSQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGIVLQEPIISAKIPQGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:362950", "resource": "KEGG Pathway", "id": "rno:362950", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6803529", "resource": "Reactome", "id": "R-RNO-6803529", "name": "FGFR2 alternative splicing" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1#function", "annotation": "RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1#function", "id": "A1A5R1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "annotation": "Results demonstrated a distinct populations of Rbfox2 variants in the adult brain which is consistent with neuronal transcript diversity. Novel variants in PC12 cells is suggestive of a multiplicity of Rbfox2 transcript populations that may be a defining feature of individual cell types. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O43251-1", "protein_name": "RNA binding protein fox-1 homolog 2; RNA-binding protein 9; Repressor of tamoxifen transcriptional activity; Fox-1 homolog B; RNA-binding motif protein 9; Hexaribonucleotide-binding protein 2.", "sequence": { "length": 390, "sequence": "MQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/49375", "id": "49375", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BP71-1", "protein_name": "RNA binding protein fox-1 homolog 2; Fox-1 homolog Fxh; RNA-binding protein 9; Fox-1 homolog B; RNA-binding motif protein 9; Hexaribonucleotide-binding protein 2.", "sequence": { "length": 449, "sequence": "MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADGGMQNEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/49375", "id": "49375", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "ac": "NP_001073364.1", "name": "RNA binding protein fox-1 homolog 2; RNA-binding protein 9; fox-1 homolog B; RNA-binding motif protein 9; RNA-binding protein FOX2; RNA binding protein, fox-1 homolog 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "mRNA binding", "id": "GO:0003729" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "nervous system development", "id": "GO:0007399" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010724", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "regulation of definitive erythrocyte differentiation", "id": "GO:0010724" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "mRNA processing", "id": "GO:0006397" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "neuromuscular process controlling balance", "id": "GO:0050885" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "RNA splicing", "id": "GO:0008380" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "dendrite morphogenesis", "id": "GO:0048813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030520", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "intracellular estrogen receptor signaling pathway", "id": "GO:0030520" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021942", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "id": "A1A5R1", "database": "UniProtKB" } ], "name": "radial glia guided migration of Purkinje cell", "id": "GO:0021942" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 111, "annotation": "n_glycosylation_sequon", "start_pos": 109 }, { "end_pos": 133, "annotation": "n_glycosylation_sequon", "start_pos": 131 }, { "end_pos": 238, "annotation": "n_glycosylation_sequon", "start_pos": 236 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364.1", "id": "NP_001073364.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6803529", "id": "R-RNO-6803529", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:362950", "id": "rno:362950", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004688", "id": "ENSRNOG00000004688", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12407", "id": "cd12407", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "id": "IPR035979", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "id": "IPR000504", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017325", "id": "IPR017325", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR025670", "id": "IPR025670", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034237", "id": "IPR034237", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "id": "IPR012677", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00076", "id": "PF00076", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12414", "id": "PF12414", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A5R1", "id": "PR_A1A5R1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/362950", "id": "362950", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311838", "id": "1311838", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A1A5R1", "disease": [], "mass": { "monoisotopic_mass": 45550.0, "chemical_mass": 45550.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A5R1", "name": "Rbfox2; Fox2; Rbm9.", "locus": { "end_pos": 118156946, "start_pos": 118396728, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004688", "id": "ENSRNOG00000004688", "database": "Ensembl Gene" } ] } } ] }