{ "uniprot_canonical_ac": "A1A5B6-1", "sequence": { "header": "sp|A1A5B6-1|TBC25_MOUSE Isoform 1 of TBC1 domain family member 25 OS=Mus musculus OX=10090 GN=Tbc1d25 PE=1 SV=1 CANONICAL=A1A5B6-1", "length": 742, "sequence": "MRPPAQARWEGQGPTAPLRLRSGARWGRGRPHCWVYVRVRVTIGYHLDRDDSGGMATTSAASDSACSAAPPPVGGAQAAAAVEEEEREVVRVRVKKCESFLSPEFRSFAVDPQITSLDVLQHILIRAFDLNGKKNFGISYLARDRLGQETFLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILSQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRVNPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGSHRGRPVRQRHMLRPAGGGGGAFEDAVVHLAASSQGPSGGGRLLRQASLDGLQQLRDNMGLRKDHLVQLSHPATLISSKSLSEPLLNSPDPLLSTSSRPDSPSSSSPPSTQEASPSGDIAVGSPLMQEVGSPRDPGKPVPPPPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKALFADYLQSEVWDSEEGAEATAPS" }, "uniprot_id": "TBC25_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "TBC1 domain family member 25 isoform 2", "ornithine aminotransferase-like 1" ], "uniprotkb": [ "TBC1 domain family member 25" ] }, "gene": { "refseq": [ "Tbc1d25", "6330576A08Rik", "DXHXS7927e", "Oatl1" ], "uniprotkb": [ "Tbc1d25", "6330576A08Rik", "DXHXS7927e", "Oatl1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "TBC1 domain family member 25." }, "publication": [ { "title": "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21383079", "journal": "The Journal of cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159909.1", "id": "NP_001159909.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A1A5B6/publications", "id": "A1A5B6", "database": "UniProtKB" } ], "authors": "Itoh T, Kanno E, Uemura T, Waguri S, Fukuda M", "date": "2011", "pmid": "21383079" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6#A1A5B6-1", "isoform_ac": "A1A5B6-1", "locus": { "end_pos": 8154708, "start_pos": 8175995, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000039892", "id": "ENSMUST00000039892", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000047838", "id": "ENSMUSP00000047838", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A5B6-1|TBC25_MOUSE Isoform 1 of TBC1 domain family member 25 OS=Mus musculus OX=10090 GN=Tbc1d25 PE=1 SV=1 CANONICAL=A1A5B6-1", "length": 742, "sequence": "MRPPAQARWEGQGPTAPLRLRSGARWGRGRPHCWVYVRVRVTIGYHLDRDDSGGMATTSAASDSACSAAPPPVGGAQAAAAVEEEEREVVRVRVKKCESFLSPEFRSFAVDPQITSLDVLQHILIRAFDLNGKKNFGISYLARDRLGQETFLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILSQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRVNPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGSHRGRPVRQRHMLRPAGGGGGAFEDAVVHLAASSQGPSGGGRLLRQASLDGLQQLRDNMGLRKDHLVQLSHPATLISSKSLSEPLLNSPDPLLSTSSRPDSPSSSSPPSTQEASPSGDIAVGSPLMQEVGSPRDPGKPVPPPPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKALFADYLQSEVWDSEEGAEATAPS" } }, { "url": "https://www.uniprot.org/uniprot/A1A5B6#S4R2S6-1", "isoform_ac": "S4R2S6-1", "locus": { "end_pos": 8154708, "start_pos": 8174204, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000143984", "id": "ENSMUST00000143984", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000138768", "id": "ENSMUSP00000138768", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|S4R2S6-1|TBC25_MOUSE Computationally mapped isoform of TBC1 domain family member 25 OS=Mus musculus OX=10090 GN=Tbc1d25 PE=1 SV=1 CANONICAL=A1A5B6-1", "length": 560, "sequence": "MGPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILSQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRVNPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGSHRGRPVRQRHMLRPAGGGGGAFEDAVVHLAASSQGPSGGGRLLRQASLDGLQQLRDNMGLRKDHLVQLSHPATLISSKSLSEPLLNSPDPLLSTSSRPDSPSSSSPPSTQEASPSGDIAVGSPLMQEVGSPRDPGKPVPPPPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKALFADYLQSEVWDSEEGAEATAPS" } }, { "url": "https://www.uniprot.org/uniprot/A1A5B6#E9PWX7-1", "isoform_ac": "E9PWX7-1", "locus": { "end_pos": 8154708, "start_pos": 8176145, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000172020", "id": "ENSMUST00000172020", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000131652", "id": "ENSMUSP00000131652", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PWX7-1|TBC25_MOUSE Computationally mapped isoform of TBC1 domain family member 25 OS=Mus musculus OX=10090 GN=Tbc1d25 PE=1 SV=1 CANONICAL=A1A5B6-1", "length": 723, "sequence": "MNPEVNCQNNGATDRARQDLDRHLHTGSKKDDSGGMATTSAASDSACSAAPPPVGGAQAAAAVEEEEREVVRVRVKKCESFLSPEFRSFAVDPQITSLDVLQHILIRAFDLNGKKNFGISYLARDRLGQETFLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILSQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRVNPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGSHRGRPVRQRHMLRPAGGGGGAFEDAVVHLAASSQGPSGGGRLLRQASLDGLQQLRDNMGLRKDHLVQLSHPATLISSKSLSEPLLNSPDPLLSTSSRPDSPSSSSPPSTQEASPSGDIAVGSPLMQEVGSPRDPGKPVPPPPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKALFADYLQSEVWDSEEGAEATAPS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:209815", "resource": "KEGG Pathway", "id": "mmu:209815", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854214", "resource": "Reactome", "id": "R-MMU-8854214", "name": "TBC/RABGAPs" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6#function", "annotation": "Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6#function", "id": "A1A5B6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159909.1", "annotation": "OATL1 has a role in autophagy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159909.1", "id": "NP_001159909.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3MII6-1", "protein_name": "TBC1 domain family member 25.", "sequence": { "length": 688, "sequence": "MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQITSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADYLQSEVWDSEEGAEATAAS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1A5B6/", "id": "A1A5B6", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/16173", "id": "16173", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "B1WBS1-1", "protein_name": "TBC1 domain family, member 25; Ornithine aminotransferase-like 1 (Predicted).", "sequence": { "length": 688, "sequence": "MATTSAASDLACSAAPSPVGGASAAAAVEEEEREVVRVRVKKCESFLSPEFRSFAVDPQITSLDVLQHILIRAFDLNGKKNFGISYLARDRLGQEAFLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLADKRSSLTTAALPFTQSILSQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRVNPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGSHRGRPVRQRHMLRPAGGGSSAFEDAVVHLATSSQGPSSGGRLLRQASLDGLQQLRDNMSPRKDLLVQLSHPATLISSKSLSEPLLNSPDPLLSSSSRPDSPSSSSPPSTQEASPSGDVAVGSPSMPEVGSPRDPGKSVPPPPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKALFADYLQSEVWDSEEGAEATAPS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1A5B6/", "id": "A1A5B6", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/16173", "id": "16173", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159909.1", "ac": "NP_001159909.1", "name": "TBC1 domain family member 25 isoform 2; ornithine aminotransferase-like 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017137", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "Rab GTPase binding", "id": "GO:0017137" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "autophagosome", "id": "GO:0005776" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "intracellular protein transport", "id": "GO:0006886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "activation of GTPase activity", "id": "GO:0090630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "autophagy", "id": "GO:0006914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "id": "A1A5B6", "database": "UniProtKB" } ], "name": "regulation of autophagosome maturation", "id": "GO:1901096" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159909.1", "id": "NP_001159909.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854214", "id": "R-MMU-8854214", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:209815", "id": "mmu:209815", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039201", "id": "ENSMUSG00000039201", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/VKVKKCD/", "id": "VKVKKCD", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "id": "IPR035969", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "id": "IPR000195", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00566", "id": "PF00566", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A5B6", "id": "PR_A1A5B6", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/209815", "id": "209815", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2444862", "id": "2444862", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A1A5B6", "disease": [], "mass": { "monoisotopic_mass": 82575.0, "chemical_mass": 82575.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A5B6", "name": "Tbc1d25; 6330576A08Rik; DXHXS7927e; Oatl1.", "locus": { "end_pos": 8154472, "start_pos": 8176181, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000039201", "id": "ENSMUSG00000039201", "database": "Ensembl Gene" } ] } } ] }