{ "uniprot_canonical_ac": "A1A546-1", "sequence": { "header": "sp|A1A546-1|ISX_MOUSE Isoform 1 of Intestine-specific homeobox OS=Mus musculus OX=10090 GN=Isx PE=2 SV=2 CANONICAL=A1A546-1", "length": 240, "sequence": "MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPRPQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGEAGLALPSNMDVSGPVLTPTAMTTLVPPTECCLLSQTQLPSSWFPTQIPLVPWHPWDLQPLPGPLTQHPCVPTFMFPPLHPKWGSICATST" }, "uniprot_id": "ISX_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "intestine-specific homeobox isoform 1", "pancreas-intestine homeodomain transcription factor" ], "uniprotkb": [ "Intestine-specific homeobox" ] }, "gene": { "refseq": [ "Isx", "9130012O13Rik", "Pix-1" ], "uniprotkb": [ "Isx", "9130012O13Rik", "Pix-1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Intestine-specific homeobox." }, "publication": [ { "title": "The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24005908", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ], "authors": "Billings SE, Pierzchalski K, Butler Tjaden NE, Pang XY, Trainor PA, Kane MA, Moise AR", "date": "2013", "pmid": "24005908" }, { "title": "Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23393141", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ], "authors": "Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J", "date": "2013", "pmid": "23393141" }, { "title": "Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20932939", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ], "authors": "Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL", "date": "2011", "pmid": "20932939" }, { "title": "Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18093975", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A1A546/publications", "id": "A1A546", "database": "UniProtKB" } ], "authors": "Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S", "date": "2008", "pmid": "18093975" }, { "title": "A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16971476", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546/publications", "id": "A1A546", "database": "UniProtKB" } ], "authors": "Hu M., Krieger M., Lepourcelet M., Shivdasani R.A., Choi M.Y., Gray P.A., Mechoor A., Romer A.I., Yesilaltay A.", "date": "2006", "pmid": "16971476" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A546#A1A546-1", "isoform_ac": "A1A546-1", "locus": { "end_pos": 74873641, "start_pos": 74892901, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000034034", "id": "ENSMUST00000034034", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000034034", "id": "ENSMUSP00000034034", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A546-1|ISX_MOUSE Isoform 1 of Intestine-specific homeobox OS=Mus musculus OX=10090 GN=Isx PE=2 SV=2 CANONICAL=A1A546-1", "length": 240, "sequence": "MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPRPQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGEAGLALPSNMDVSGPVLTPTAMTTLVPPTECCLLSQTQLPSSWFPTQIPLVPWHPWDLQPLPGPLTQHPCVPTFMFPPLHPKWGSICATST" } }, { "url": "https://www.uniprot.org/uniprot/A1A546#A1A546-2", "isoform_ac": "A1A546-2", "locus": { "end_pos": 74873641, "start_pos": 74892948, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000174427", "id": "ENSMUST00000174427", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134368", "id": "ENSMUSP00000134368", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A546-2|ISX_MOUSE Isoform 2 of Intestine-specific homeobox OS=Mus musculus OX=10090 GN=Isx PE=2 SV=2 CANONICAL=A1A546-1", "length": 242, "sequence": "MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPRPQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGSCADTHCYDYIGTSHRMLPTLSDSAPFKLVPYTDSPCPMAPMGPTAPAWPSHPASLCPYLHVPTPTPQVGQHLCNFNIGTDFSLSKQATLLSQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:71597", "resource": "KEGG Pathway", "id": "mmu:71597", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A546#function", "annotation": "Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546#function", "id": "A1A546", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "annotation": "Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "annotation": "Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M478-1", "protein_name": "Intestine-specific homeobox.", "sequence": { "length": 242, "sequence": "MAGPTIQRDIEKSSGYCEAPEKLGLSFSIEAILKRPTERRNLPRPQSIGGGDSRQTTTSGSKLEKPTQDQPQEERKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGSLSAPQQPGSCTDAHCSAHIGATHRMLPPLSDSARFKLVPCPDSPCPMAPMGPAAPAWPSHPAALCPYLHPPTPKPQVGQHLCNANIRTGFSLPKQATLLPQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28312", "id": "28312", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q2M1V0-1", "protein_name": "Intestine-specific homeobox; RAX-like homeobox.", "sequence": { "length": 245, "sequence": "MCAEVGPALCRGMERNSLGCCEAPKKLSLSFSIEAILKRPARRSDMDRPEGPGEEGPGEAAASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAGPTWTSTALRRLAPPTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVPGLPIHQTCIPVLCILPPPHPKWGSICATST" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1A546/", "id": "A1A546", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/28312", "id": "28312", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "ac": "NP_001281207.1", "name": "intestine-specific homeobox isoform 1; pancreas-intestine homeodomain transcription factor.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904479", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "negative regulation of intestinal absorption", "id": "GO:1904479" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901738", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "regulation of vitamin A metabolic process", "id": "GO:1901738" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 143, "annotation": "n_glycosylation_sequon", "start_pos": 141 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:71597", "id": "mmu:71597", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031621", "id": "ENSMUSG00000031621", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WETQPLP/", "id": "WETQPLP", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "id": "cd00086", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "id": "IPR001356", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "id": "IPR017970", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00046", "id": "PF00046", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A546", "id": "PR_A1A546", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/71597", "id": "71597", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1918847", "id": "1918847", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A1A546", "disease": [], "mass": { "monoisotopic_mass": 27169.0, "chemical_mass": 27169.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "name": "Isx; 9130012O13Rik; Pix-1.", "locus": { "end_pos": 74893506, "start_pos": 74873173, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000031621", "id": "ENSMUSG00000031621", "database": "Ensembl Gene" } ] } } ] }