{ "uniprot_canonical_ac": "A1A535-1", "sequence": { "header": "sp|A1A535-1|MELT_MOUSE Isoform 1 of Ventricular zone-expressed PH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Veph1 PE=2 SV=2 CANONICAL=A1A535-1", "length": 833, "sequence": "MHQLFRLVLGQKDLSKAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIIKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKDSTYNDIILNILIEIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHPFHHILLLEIKSITDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLENSKADSSRRKTSTEVSIPEKLRELNSMEPESEDHEKLQVKIQAFEDKINAESNTPGSGRRYSLDHISKEERKSIRFSRSRSLALNTVLTNGVSVEDNEVEEKAGMHASISLSQIDPLSHGIGKLPFKTDTHGSPLRNSSASHPSIIHTEPETMPETFKENIQEEILEAATSPIEYQDKLYLHLRENLSKVKAYALEIAKKVPIPDQCTIEDTMRSCVAKLFFTCSLKGHYCLYSKSSFILVSQAPQPWIQVMFLSQQSLFPEPLSIQSGSVQFLKALWEKTQDTGAHSFEVAMTESTFPQQKDLEQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTHYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL" }, "uniprot_id": "MELT_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ventricular zone-expressed PH domain-containing protein 1", "protein melted homolog" ], "uniprotkb": [ "Ventricular zone-expressed PH domain-containing protein 1", "Protein melted homolog" ] }, "gene": { "refseq": [ "Veph1", "2810471M23Rik", "Veph" ], "uniprotkb": [ "Veph1", "Veph", "2810471M23Rik" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A535", "id": "A1A535", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Ventricular zone-expressed PH domain-containing protein 1; Protein melted homolog." }, "publication": [ { "title": "Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-beta receptor I to inhibit TGF-beta signaling.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26039994", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819.2", "id": "NP_665819.2", "database": "RefSeq" } ], "authors": "Shathasivam P, Kollara A, Ringuette MJ, Virtanen C, Wrana JL, Brown TJ", "date": "2015", "pmid": "26039994" }, { "title": "Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15388229", "journal": "Biochimie", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819.2", "id": "NP_665819.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A1A535/publications", "id": "A1A535", "database": "UniProtKB" } ], "authors": "Muto E, Tabata Y, Taneda T, Aoki Y, Muto A, Arai K, Watanabe S", "date": "2004", "pmid": "15388229" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A535#A1A535-1", "isoform_ac": "A1A535-1", "locus": { "end_pos": 66057108, "start_pos": 66264019, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000029419", "id": "ENSMUST00000029419", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000029419", "id": "ENSMUSP00000029419", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A535-1|MELT_MOUSE Isoform 1 of Ventricular zone-expressed PH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Veph1 PE=2 SV=2 CANONICAL=A1A535-1", "length": 833, "sequence": "MHQLFRLVLGQKDLSKAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIIKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKDSTYNDIILNILIEIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHPFHHILLLEIKSITDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLENSKADSSRRKTSTEVSIPEKLRELNSMEPESEDHEKLQVKIQAFEDKINAESNTPGSGRRYSLDHISKEERKSIRFSRSRSLALNTVLTNGVSVEDNEVEEKAGMHASISLSQIDPLSHGIGKLPFKTDTHGSPLRNSSASHPSIIHTEPETMPETFKENIQEEILEAATSPIEYQDKLYLHLRENLSKVKAYALEIAKKVPIPDQCTIEDTMRSCVAKLFFTCSLKGHYCLYSKSSFILVSQAPQPWIQVMFLSQQSLFPEPLSIQSGSVQFLKALWEKTQDTGAHSFEVAMTESTFPQQKDLEQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTHYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL" } }, { "url": "https://www.uniprot.org/uniprot/A1A535#A1A535-2", "isoform_ac": "A1A535-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A1A535-2|MELT_MOUSE Isoform 2 of Ventricular zone-expressed PH domain-containing protein 1 OS=Mus musculus OX=10090 GN=Veph1 PE=2 SV=2 CANONICAL=A1A535-1", "length": 253, "sequence": "MRSCVAKLFFTCSLKGHYCLYSKSSFILVSQAPQPWIQVMFLSQQSLFPEPLSIQSGSVQFLKALWEKTQDTGAHSFEVAMTESTFPQQKDLEQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTHYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:72789", "resource": "KEGG Pathway", "id": "mmu:72789", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A535#function", "annotation": "Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A535#function", "id": "A1A535", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819.2", "annotation": "Veph was strongly expressed in the ventricular zone of the embryonic brain, and its expression level gradually decreased in later stages.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819.2", "id": "NP_665819.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5PQS3-1", "protein_name": "Ventricular zone-expressed PH domain-containing protein homolog 1; Protein melted homolog.", "sequence": { "length": 832, "sequence": "MHQLFRLVLGQKDLSRAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIVKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKESTYNDIILNILIEIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHSFHHILLLEIKSLTDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLENSKAESGRRRTGTEVSFPEKFREPKTMEPKSEDHEKLQVKIQAFEDKINAESHTPGSVRRYSLDHVSKEERKNVRFSRSRSLALNTVLTNSVNVEDGEIEGKTGMHASISLSEIDPPGHGIGKVPFKTDTHGSQLRNSSASHPSIIHSEPENMPETFKENVQEEIPEAAISPVEYQDKLYLHLKENLSKVKAYALEIAKKVPIPDQCTIEDNTRSCVAKLFFTCSLKGHYCLYSKSSFTLVSQAPQPWIQIMFLFQQSLFPEPLSIQSGSVQFLKALWEKTQGTGTHSFEVAMTESTFPQQKDLDQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11624", "id": "11624", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q14D04-1", "protein_name": "Ventricular zone-expressed PH domain-containing protein homolog 1; Protein melted.", "sequence": { "length": 833, "sequence": "MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11624", "id": "11624", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819.2", "ac": "NP_665819.2", "name": "ventricular zone-expressed PH domain-containing protein 1; protein melted homolog.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A535", "id": "A1A535", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A535", "id": "A1A535", "database": "UniProtKB" } ], "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060392", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A535", "id": "A1A535", "database": "UniProtKB" } ], "name": "negative regulation of SMAD protein signal transduction", "id": "GO:0060392" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 123, "annotation": "n_glycosylation_sequon", "start_pos": 121 }, { "end_pos": 149, "annotation": "n_glycosylation_sequon", "start_pos": 147 }, { "end_pos": 507, "annotation": "n_glycosylation_sequon", "start_pos": 505 }, { "end_pos": 556, "annotation": "n_glycosylation_sequon", "start_pos": 554 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819.2", "id": "NP_665819.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:72789", "id": "mmu:72789", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027831", "id": "ENSMUSG00000027831", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/LQGNAML/", "id": "LQGNAML", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039888", "id": "IPR039888", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00169", "id": "PF00169", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21630", "id": "PTHR21630", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A535", "id": "PR_A1A535", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/72789", "id": "72789", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1920039", "id": "1920039", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A1A535", "disease": [], "mass": { "monoisotopic_mass": 94502.0, "chemical_mass": 94502.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A535", "name": "Veph1; Veph; 2810471M23Rik.", "locus": { "end_pos": 66053558, "start_pos": 66296837, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000027831", "id": "ENSMUSG00000027831", "database": "Ensembl Gene" } ] } } ] }