{
    "uniprot_canonical_ac": "A1A4V9-1", 
    "sequence": {
        "header": "sp|A1A4V9-1|CC189_HUMAN Isoform 1 of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
        "length": 331, 
        "sequence": "MLNRKTSHFLGMRVQSELEHLSELRREAGKDRSSVHGSAARTRASVRTQWTTAAAAKADEDPGANLFPPPLPRPRICMWKYLDVHSMHQLEKTTNAEMREVLAELLELGCPEQSLRDAITLDLFCHALIFCRQQGFSLEQTSAACALLQDLHKACIATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALEDYVVNTYFRHFKLYKYVFTPQVRLDLSLTYMGLQPPKLWPESETEKEESKEMEEQAVTPQKEELETVAPPEPEPSHIHVLRAYIKTQVNKELEQLQGLVEERLKASEERLSSKLTALERPFQLPPGKGKSKTK"
    }, 
    "uniprot_id": "CC189_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "coiled-coil domain-containing protein 189 isoform 1", 
                "coiled-coil domain-containing protein 189"
            ], 
            "uniprotkb": [
                "Coiled-coil domain-containing protein 189"
            ]
        }, 
        "gene": {
            "refseq": [
                "CCDC189", 
                "C16orf93"
            ], 
            "uniprotkb": [
                "CCDC189", 
                "C16orf93"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Coiled-coil domain-containing protein 189."
    }, 
    "publication": [
        {
            "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12477932", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014979.2", 
                    "id": "NP_001014979.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA", 
            "date": "2002", 
            "pmid": "12477932"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 271, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "50", 
            "end_pos": 271, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 7, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "S", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "end_pos": 7, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#A1A4V9-1", 
            "isoform_ac": "A1A4V9-1", 
            "locus": {
                "end_pos": 30757479, 
                "start_pos": 30761748, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000543610", 
                        "id": "ENST00000543610", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000437532", 
                        "id": "ENSP00000437532", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1A4V9-1|CC189_HUMAN Isoform 1 of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 331, 
                "sequence": "MLNRKTSHFLGMRVQSELEHLSELRREAGKDRSSVHGSAARTRASVRTQWTTAAAAKADEDPGANLFPPPLPRPRICMWKYLDVHSMHQLEKTTNAEMREVLAELLELGCPEQSLRDAITLDLFCHALIFCRQQGFSLEQTSAACALLQDLHKACIATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALEDYVVNTYFRHFKLYKYVFTPQVRLDLSLTYMGLQPPKLWPESETEKEESKEMEEQAVTPQKEELETVAPPEPEPSHIHVLRAYIKTQVNKELEQLQGLVEERLKASEERLSSKLTALERPFQLPPGKGKSKTK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#H0YGC5-1", 
            "isoform_ac": "H0YGC5-1", 
            "locus": {
                "end_pos": 30757478, 
                "start_pos": 30759724, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000535476", 
                        "id": "ENST00000535476", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000442644", 
                        "id": "ENSP00000442644", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H0YGC5-1|CC189_HUMAN Computationally mapped isoform of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=2 CANONICAL=A1A4V9-1", 
                "length": 145, 
                "sequence": "XTPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALEDYVVNTYFRHFKLYKYVFTPQVRLDLSLTYMGLQPPKLWPESETGHIHVLRAYIKTQVNKELEQLQGLVEERLKASEERLSSKLTALERPFQLPPGKGKSKTK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#A1A4V9-2", 
            "isoform_ac": "A1A4V9-2", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A1A4V9-2|CC189_HUMAN Isoform 2 of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 294, 
                "sequence": "MASYSGFSGLLEIRYGPGHRSCLPQFAFFPQPPLPRPRICMWKYLDVHSMHQLEKTTNAEMREVLAELLELGCPEQSLRDAITLDLFCHALIFCRQQGFSLEQTSAACALLQDLHKACIATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALEDYVVNTYFRHFKLYKYVFTPQVRLDLSLTYMGLQPPKLWPESETEKEESKEMEEQAVTPQKEELETVAPPEPEPSHIHVLRAYIKTQVNKELEQLQGLVEERLKASEERLSSKLTALERPFQLPPGKGKSKTK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#F5H7A8-1", 
            "isoform_ac": "F5H7A8-1", 
            "locus": {
                "end_pos": 30761327, 
                "start_pos": 30761748, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000545809", 
                        "id": "ENST00000545809", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000442648", 
                        "id": "ENSP00000442648", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F5H7A8-1|CC189_HUMAN Computationally mapped isoform of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 71, 
                "sequence": "MLNRKTSHFLGMRVQSELEHLSELRREAGKDRSSVHGSAARTRASVRTQWTTAAAAKADEDPGANLFPSLR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#A1A4V9-3", 
            "isoform_ac": "A1A4V9-3", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A1A4V9-3|CC189_HUMAN Isoform 3 of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 103, 
                "sequence": "MGLQPPKLWPESETEKEESKEMEEQAVTPQKEELETVAPPEPEPSHIHVLRAYIKTQVNKELEQLQGLVEERLKASEERLSSKLTALERPFQLPPGKGKSKTK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#H3BNW1-1", 
            "isoform_ac": "H3BNW1-1", 
            "locus": {
                "end_pos": 30759228, 
                "start_pos": 30760419, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000544613", 
                        "id": "ENST00000544613", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000455034", 
                        "id": "ENSP00000455034", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H3BNW1-1|CC189_HUMAN Computationally mapped isoform of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 91, 
                "sequence": "XAEPEGRHHPGPLLPRAHFLPPAGLLTGADVSGLCPAPGSSQGLYCGLLSASTSSKRNSCWPWKTTWSTLTSATSSSINTSSHPRCGWICL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#A1A4V9-4", 
            "isoform_ac": "A1A4V9-4", 
            "locus": {
                "end_pos": 30760222, 
                "start_pos": 30761748, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000545825", 
                        "id": "ENST00000545825", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000441164", 
                        "id": "ENSP00000441164", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1A4V9-4|CC189_HUMAN Isoform 4 of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 177, 
                "sequence": "MLNRKTSHFLGMRVQSELEHLSELRREAGKDRSSVHGSAARTRASVRTQWTTAAAAKADEDPGANLFPPPLPRPRICMWKYLDVHSMHQLEKTTNAEMREVLAELLELGCPEQSLRDAITLDLFCHALIFCRQQGFSLEQTSAACALLQDLHKACIGERGQLPGLSPREKRNRAWHK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A4V9#H3BTQ9-1", 
            "isoform_ac": "H3BTQ9-1", 
            "locus": {
                "end_pos": 30757479, 
                "start_pos": 30761748, 
                "chromosome": "16", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000541260", 
                        "id": "ENST00000541260", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000457287", 
                        "id": "ENSP00000457287", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H3BTQ9-1|CC189_HUMAN Computationally mapped isoform of Coiled-coil domain-containing protein 189  OS=Homo sapiens OX=9606 GN=CCDC189 PE=2 SV=1 CANONICAL=A1A4V9-1", 
                "length": 396, 
                "sequence": "MLNRKTSHFLGMRVQSELEHLSELRREAGKDRSSVHGSAARTRASVRTQWTTAAAAKADEDPGANLFPPPLPRPRICMWKYLDVHSMHQLEKTTNAEMREVLAELLELGCPEQSLRDAITLDLFCHALIFCRQQGFSLEQTSAACALLQDLHKACIATPLGNVEECYRYFTSVLFCHGVRVSSPGTFWKLYPSPDKVSPSLSHIHHPYLLVKTPVGSPCSCCWAFGGKARAPEGSQGSNSESPPQRPPFSIDLFKEEQLLALEDYVVNTYFRHFKLYKYVFTPQVRLDLSLTYMGLQPPKLWPESETEKEESKEMEEQAVTPQKEELETVAPPEPEPSHIHVLRAYIKTQVNKELEQLQGLVEERLKASEERLSSKLTALERPFQLPPGKGKSKTK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:90835", 
            "resource": "KEGG Pathway", 
            "id": "hsa:90835", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "B0BMZ6-1", 
            "protein_name": "RCG40079, isoform CRA_a; Coiled-coil domain-containing 189; LOC691909 protein.", 
            "sequence": {
                "length": 332, 
                "sequence": "MITPRSSQSLEMKVQTELEHSPKLQEEPDRSPSLVDSSVIRIGTDEQNESPAEATSSPVEVAEDPGANLFPPPLPQPRICMWKYLDIHSMHRLEKAATVEEMREVLAELLELGGPEQSLRDAIILDLFSHALIFCRQQGFSLEQTSAACALLQDLHKACVATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALADYVVNTYFRHFKLYKYVFTPQVRLDLSLSYMGLQSLHLWPEEKEDEEATVEQAATPQEEEPEAVTEAEQQPSEVCILQTYIKCQLNKELRQLQQLVEERLKESEERLSNRLAALERPYQTPPSKGKSKAK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/79950", 
                    "id": "79950", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q6NZQ0-1", 
            "protein_name": "Coiled-coil domain-containing protein 189.", 
            "sequence": {
                "length": 333, 
                "sequence": "MITPSSSQSLGMKVQMESEQSPKLQEELDRSPSSVDGSAIRNGTDMQTESPAEATSSPVEVAEDPGANLFPPPLPQPRICMWKYLDIHSMHRLEKAATVEKMREVLAELLELGFPEQSLRDAIILDLFSHALIFCRQQGFSPEQTSAACAMLQDLHKACVATPLGNVEECYRYFTSVLFCHGIRRPPFSIDLFKEEQLLALADYVVNTYFRHFKLYKYVFTPQVRLDLSLTYTGLQPLTLWPEEKENEEMMVVEQVATPQEEEPETVTEPEQQPSEVCILQTYIKSQLSKELRQLQQLVEERLKESEERLSSKLAALEQPFQTPPSKGKTKTK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/79950", 
                    "id": "79950", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014979.2", 
        "ac": "NP_001014979.2", 
        "name": "coiled-coil domain-containing protein 189 isoform 1; coiled-coil domain-containing protein 189.", 
        "summary": ""
    }, 
    "go_annotation": {}, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014979.2", 
            "id": "NP_001014979.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=28078", 
            "id": "28078", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A1A4V9", 
            "id": "A1A4V9", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A1A4V9", 
            "id": "NX_A1A4V9", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCDC189", 
            "id": "CCDC189", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:90835", 
            "id": "hsa:90835", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196118", 
            "id": "ENSG00000196118", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032727", 
            "id": "IPR032727", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF14769", 
            "id": "PF14769", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28457", 
            "id": "PTHR28457", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A4V9", 
            "id": "PR_A1A4V9", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A1A4V9*", 
            "id": "A1A4V9", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/90835", 
            "id": "90835", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4V9", 
                    "id": "A1A4V9", 
                    "database": "BioXpress"
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        "chemical_mass": 37921.0
    }, 
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                "uberon": "0002369", 
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            "evidence": [
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        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
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                "name": "Ovary"
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            "evidence": [
                {
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                    "id": "ENSG00000196118", 
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        {
            "tissue": {
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                "name": "Vagina"
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                    "id": "ENSG00000196118", 
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        {
            "tissue": {
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            "tissue": {
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            "tissue": {
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            "tissue": {
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            "tissue": {
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        {
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        {
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    "gene": [
        {
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                        "id": "ENSG00000196118", 
                        "database": "Ensembl Gene"
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                ]
            }
        }
    ]
}