{ "uniprot_canonical_ac": "A1A4S6-1", "sequence": { "header": "sp|A1A4S6-1|RHG10_HUMAN Isoform 1 of Rho GTPase-activating protein 10 OS=Homo sapiens OX=9606 GN=ARHGAP10 PE=1 SV=1 CANONICAL=A1A4S6-1", "length": 786, "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL" }, "uniprot_id": "RHG10_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "rho GTPase-activating protein 10", "graf-related protein 2; rho-type GTPase-activating protein 10; GTPase regulator associated with focal adhesion kinase 2" ], "uniprotkb": [ "Rho GTPase-activating protein 10", "Rho-type GTPase-activating protein 10", "GTPase regulator associated with focal adhesion kinase 2", "Graf-related protein 2" ] }, "gene": { "refseq": [ "ARHGAP10", "GRAF2", "PS-GAP", "PSGAP" ], "uniprotkb": [ "ARHGAP10", "GRAF2", "PS-GAP", "PSGAP" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10; GTPase regulator associated with focal adhesion kinase 2; Graf-related protein 2." }, "publication": [ { "title": "ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27010858", "journal": "Cell death & disease", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Luo N, Guo J, Chen L, Yang W, Qu X, Cheng Z", "date": "2016", "pmid": "27010858" }, { "title": "A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20158304", "journal": "Twin research and human genetics : the official journal of the International Society for Twin Studies", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Lind PA, Macgregor S, Vink JM, Pergadia ML, Hansell NK, de Moor MH, Smit AB, Hottenga JJ, Richter MM, Heath AC, Martin NG, Willemsen G, de Geus EJ, Vogelzangs N, Penninx BW, Whitfield JB, Montgomery GW, Boomsma DI, Madden PA", "date": "2010", "pmid": "20158304" }, { "title": "A genome-wide association study of prognosis in breast cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20332263", "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Azzato EM, Pharoah PD, Harrington P, Easton DF, Greenberg D, Caporaso NE, Chanock SJ, Hoover RN, Thomas G, Hunter DJ, Kraft P", "date": "2010", "pmid": "20332263" }, { "title": "Mutation of ARHGAP9 in patients with coronary spastic angina.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19911011", "journal": "Journal of human genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K", "date": "2010", "pmid": "19911011" }, { "title": "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20031603", "journal": "Circulation. Cardiovascular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, Wild SH, Oostra BA, Wright AF, Campbell H, Witteman JC, Kaab S, Hicks AA, Gyllensten U, Rudan I, Meitinger T, Pattaro C, van Duijn CM, Wilson JF, Pramstaller PP", "date": "2009", "pmid": "20031603" }, { "title": "Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15471851", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Koeppel MA, McCarthy CC, Moertl E, Jakobi R", "date": "2004", "pmid": "15471851" }, { "title": "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11432776", "journal": "Journal of biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A1A4S6/publications", "id": "A1A4S6", "database": "UniProtKB" } ], "authors": "Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y", "date": "2001", "pmid": "11432776" }, { "title": "Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8288572", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ], "authors": "Lancaster CA, Taylor-Harris PM, Self AJ, Brill S, van Erp HE, Hall A", "date": "1994", "pmid": "8288572" } ], "glycosylation": [], "mutation": [ { "start_pos": 681, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs758074651.", "sequence_org": "R", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "*", "subjects_tested": "499", "end_pos": 681, "type": "Point mutation" }, { "start_pos": 140, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "K", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "R", "subjects_tested": "50", "end_pos": 140, "type": "Point mutation" }, { "start_pos": 7, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "E", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 7, "type": "Point mutation" }, { "start_pos": 315, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "D", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "Liver cancer" }, "sequence_mut": "G", "subjects_tested": "412", "end_pos": 315, "type": "Point mutation" }, { "start_pos": 681, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs758074651.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "*", "subjects_tested": "456", "end_pos": 681, "type": "Point mutation" }, { "start_pos": 671, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "1.5", "annotation": "Filters passed (1/5): patient freq. (1.5%).", "sequence_org": "D", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "Y", "subjects_tested": "66", "end_pos": 671, "type": "Point mutation" }, { "start_pos": 681, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "0.4", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs758074651.", "sequence_org": "R", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "Esophageal cancer" }, "sequence_mut": "*", "subjects_tested": "228", "end_pos": 681, "type": "Point mutation" }, { "start_pos": 315, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "D", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "Prostate cancer" }, "sequence_mut": "G", "subjects_tested": "1118", "end_pos": 315, "type": "Point mutation" }, { "start_pos": 315, "subjects_positive": "3", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1A4S6", "id": "A1A4S6", "database": "BioMuta" } ], "frequency": "0.8", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "D", "disease": { "doid": "1793", "url": "http://disease-ontology.org/term/DOID:1793", "icd10": "", "name": "Pancreatic cancer" }, "sequence_mut": "G", "subjects_tested": "399", "end_pos": 315, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6#A1A4S6-1", "isoform_ac": "A1A4S6-1", "locus": { "end_pos": 147732302, "start_pos": 148072078, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000336498", "id": "ENST00000336498", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000336923", "id": "ENSP00000336923", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A4S6-1|RHG10_HUMAN Isoform 1 of Rho GTPase-activating protein 10 OS=Homo sapiens OX=9606 GN=ARHGAP10 PE=1 SV=1 CANONICAL=A1A4S6-1", "length": 786, "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL" } }, { "url": "https://www.uniprot.org/uniprot/A1A4S6#H0Y8W5-1", "isoform_ac": "H0Y8W5-1", "locus": { "end_pos": 147881867, "start_pos": 148072080, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000507661", "id": "ENST00000507661", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000422358", "id": "ENSP00000422358", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H0Y8W5-1|RHG10_HUMAN Computationally mapped isoform of Rho GTPase-activating protein 10 OS=Homo sapiens OX=9606 GN=ARHGAP10 PE=1 SV=1 CANONICAL=A1A4S6-1", "length": 413, "sequence": "XCTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:79658", "resource": "KEGG Pathway", "id": "hsa:79658", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-194840", "resource": "Reactome", "id": "R-HSA-194840", "name": "Rho GTPase cycle" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211728", "resource": "Reactome", "id": "R-HSA-211728", "name": "Regulation of PAK-2p34 activity by PS-GAP/RHG10" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6#function", "annotation": "GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6#function", "id": "A1A4S6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "annotation": "ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "annotation": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "annotation": "In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)).", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "annotation": "PS-GAP is a novel regulator of caspase-activated PAK-2", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4AB50-1", "protein_name": "Rho GTPase-activating protein 10; RCG51408.", "sequence": { "length": 786, "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETERNYSLIDKHLTLSARKKDTHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKTELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHIDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNELDLENSTDWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVSAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGPDGNHLAADRGNCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECLINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1A4S6/", "id": "A1A4S6", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/12695", "id": "12695", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6Y5D8-1", "protein_name": "Rho GTPase-activating protein 10; PH and SH3 domain-containing rhoGAP protein; PS-GAP; PSGAP; Rho-type GTPase-activating protein 10.", "sequence": { "length": 786, "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12695", "id": "12695", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "ac": "NP_078881.3", "name": "rho GTPase-activating protein 10; graf-related protein 2; rho-type GTPase-activating protein 10; GTPase regulator associated with focal adhesion kinase 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "negative regulation of apoptotic process", "id": "GO:0043066" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "cytoskeleton organization", "id": "GO:0007010" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "id": "A1A4S6", "database": "UniProtKB" } ], "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 143, "annotation": "n_glycosylation_sequon", "start_pos": 141 }, { "end_pos": 152, "annotation": "n_glycosylation_sequon", "start_pos": 150 }, { "end_pos": 521, "annotation": "n_glycosylation_sequon", "start_pos": 519 }, { "end_pos": 524, "annotation": "n_glycosylation_sequon", "start_pos": 522 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881.3", "id": "NP_078881.3", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26099", "id": "26099", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A1A4S6", "id": "A1A4S6", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A1A4S6", "id": "NX_A1A4S6", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ARHGAP10", "id": "ARHGAP10", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-194840", "id": "R-HSA-194840", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211728", "id": "R-HSA-211728", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:79658", "id": "hsa:79658", "database": "KEGG Pathway" }, { "url": "https://www.rcsb.org/structure/2MIO", "id": "2MIO", "database": "PDB" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PWFRERV/", "id": "PWFRERV", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12065", "id": "cd12065", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "id": "IPR000198", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "id": "IPR001452", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "id": "IPR008936", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "id": "IPR027267", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "id": "IPR036028", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035485", "id": "IPR035485", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035486", "id": "IPR035486", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00169", "id": "PF00169", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00620", "id": "PF00620", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF14604", "id": "PF14604", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12552:SF5", "id": "PTHR12552:SF5", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A4S6", "id": "PR_A1A4S6", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A1A4S6*", "id": "A1A4S6", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/79658", "id": "79658", "database": "GeneID" } ], "expression_disease": [ { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1A4S6", "id": "A1A4S6", "database": "BioXpress" } ] } ], "uniprot_ac": "A1A4S6", "disease": [], "mass": { "monoisotopic_mass": 89375.0, "chemical_mass": 89375.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000071205", "id": "ENSG00000071205", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A4S6", "name": "ARHGAP10; GRAF2; PS-GAP; PSGAP.", "locus": { "end_pos": 148072780, "start_pos": 147732063, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000071205", "id": "ENSG00000071205", "database": "Ensembl Gene" } ] } } ] }