{ "uniprot_canonical_ac": "A0S5V8-1", "sequence": { "header": "tr|A0S5V8-1|A0S5V8_RAT Isoform 1 of Chitotriosidase variant 4 OS=Rattus norvegicus OX=10116 GN=Chit1 PE=2 SV=1 CANONICAL=A0S5V8-1", "length": 464, "sequence": "MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQDLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASSSDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRSPEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDSCKCCTWG" }, "uniprot_id": "A0S5V8_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "chitotriosidase-1 precursor", "chitotriosidase-1; chitinase 1 (chitotriosidase)" ], "uniprotkb": [ "Chitotriosidase variant 4", "Chitotriosidase variant 1", "Chitotriosidase", "Chitotriosidase variant 2", "Chitotriosidase variant 3", "Chitinase 1", "Chitotriosidase variant 5" ] }, "gene": { "refseq": [ "Chit1" ], "uniprotkb": [ "Chit1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Chitotriosidase variant 4; Chitotriosidase variant 1; Chitotriosidase; Chitotriosidase variant 2; Chitotriosidase variant 3; Chitinase 1; Chitotriosidase variant 5." }, "publication": [ { "title": "Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24155872", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "id": "NP_001073157.1", "database": "RefSeq" } ], "authors": "Verwer PE, ten Kate MT, Falcone FH, Morroll S, Verbrugh HA, Bakker-Woudenberg IA, van de Sande WW", "date": "2013", "pmid": "24155872" }, { "title": "Molecular cloning and characterization of rat chitotriosidase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17852345", "journal": "DNA sequence : the journal of DNA sequencing and mapping", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "id": "NP_001073157.1", "database": "RefSeq" } ], "authors": "Chen XH, Cai GP", "date": "2008", "pmid": "17852345" }, { "title": "Identification of a novel acidic mammalian chitinase distinct from chitotriosidase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11085997", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "id": "NP_001073157.1", "database": "RefSeq" } ], "authors": "Boot RG, Blommaart EF, Swart E, Ghauharali-van der Vlugt K, Bijl N, Moe C, Place A, Aerts JM", "date": "2001", "pmid": "11085997" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8#A0S5V8-1", "isoform_ac": "A0S5V8-1", "locus": { "end_pos": 50981282, "start_pos": 50994432, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000035658", "id": "ENSRNOT00000035658", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000036477", "id": "ENSRNOP00000036477", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0S5V8-1|A0S5V8_RAT Isoform 1 of Chitotriosidase variant 4 OS=Rattus norvegicus OX=10116 GN=Chit1 PE=2 SV=1 CANONICAL=A0S5V8-1", "length": 464, "sequence": "MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQDLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASSSDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRSPEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDSCKCCTWG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:289032", "resource": "KEGG Pathway", "id": "rno:289032", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "resource": "Reactome", "id": "R-RNO-6798695", "name": "Neutrophil degranulation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189085", "resource": "Reactome", "id": "R-RNO-189085", "name": "Digestion of dietary carbohydrate" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "annotation": "Invasive pulmonary aspergillosis in immunocompromised rats caused a dramatic increase in chitinase activity. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "id": "NP_001073157.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "annotation": "Expression of cloned cDNA of chitotriosidase demonstrates that the encoded protein is secreted extracellularly and has chitinolytic activity.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "id": "NP_001073157.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9D7Q1-1", "protein_name": "Chitotriosidase-1; 3.2.1.14; Chitinase-1.", "sequence": { "length": 464, "sequence": "MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPRDVDPNLCTHVIFAFAGMDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFGTQKFTDMVATASNRQTFVKSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQDLAKAFQEEAQSSGKERLLLTAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSLEKTTGHNSPLYKRQGESGAAAEQNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASSSDNGVGAPATGPGAPGPYTKDKGVLAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDDVESFKAKAAYLKQKGLGGAMVWVLDLDDFKGSFCNQGPYPLIRTLRQELNLPSETPRSPEQIIPEPRPSSMPEQGPSPGLDNFCQGKADGVYPNPGDESTYYNCGGGRLFQQSCPPGLVFRASCKCCTWS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68318", "id": "68318", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q13231-1", "protein_name": "Chitotriosidase-1; 3.2.1.14; Chitinase-1.", "sequence": { "length": 466, "sequence": "MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68318", "id": "68318", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "ac": "NP_001073157.1", "name": "chitotriosidase-1 precursor; chitotriosidase-1; chitinase 1 (chitotriosidase).", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004568", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "chitinase activity", "id": "GO:0004568" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "chitin binding", "id": "GO:0008061" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008843", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "endochitinase activity", "id": "GO:0008843" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "extracellular region", "id": "GO:0005576" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "chitin catabolic process", "id": "GO:0006032" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "id": "A0S5V8", "database": "UniProtKB" } ], "name": "carbohydrate metabolic process", "id": "GO:0005975" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", "id": "NP_001073157.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "id": "R-RNO-6798695", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189085", "id": "R-RNO-189085", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:289032", "id": "rno:289032", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000028072", "id": "ENSRNOG00000028072", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/FYYCSGG/", "id": "FYYCSGG", "database": "OMA" }, { "url": "http://www.cazy.org/fam/CBM14.html", "id": "CBM14", "database": "CAZy" }, { "url": "http://www.cazy.org/fam/GH18.html", "id": "GH18", "database": "CAZy" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "id": "IPR017853", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001579", "id": "IPR001579", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002557", "id": "IPR002557", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036508", "id": "IPR036508", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", "id": "IPR001223", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", "id": "IPR011583", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", "id": "IPR029070", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01607", "id": "PF01607", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00704", "id": "PF00704", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/289032", "id": "289032", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305646", "id": "1305646", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0S5V8", "disease": [], "mass": { "monoisotopic_mass": 50782.0, "chemical_mass": 50782.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0S5V8", "name": "Chit1.", "locus": { "end_pos": 50994643, "start_pos": 50974872, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000028072", "id": "ENSRNOG00000028072", "database": "Ensembl Gene" } ] } } ] }