{
    "uniprot_canonical_ac": "A0PK84-1", 
    "sequence": {
        "header": "sp|A0PK84-1|ZDH22_MOUSE Isoform 1 of Palmitoyltransferase ZDHHC22  OS=Mus musculus OX=10090 GN=Zdhhc22 PE=1 SV=1 CANONICAL=A0PK84-1", 
        "length": 263, 
        "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYVLVIQNSPDDLGTCQGTMSQRPQCPPPSTHFCRVCSRVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGMAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
    }, 
    "uniprot_id": "ZDH22_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.3.1.225", 
            "activity": "Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA."
        }, 
        {
            "ec": "2.3.1.225", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "palmitoyltransferase ZDHHC22", 
                "putative palmitoyltransferase ZDHHC22; DHHC-22; zinc finger DHHC domain-containing protein 22"
            ], 
            "uniprotkb": [
                "Palmitoyltransferase ZDHHC22", 
                "2.3.1.225", 
                "Zinc finger DHHC domain-containing protein 22", 
                "DHHC-22", 
                "zDHHC22"
            ]
        }, 
        "gene": {
            "refseq": [
                "Zdhhc22", 
                "Gm262"
            ], 
            "uniprotkb": [
                "Zdhhc22", 
                "Gm262"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PK84", 
                    "id": "A0PK84", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Palmitoyltransferase ZDHHC22; 2.3.1.225; Zinc finger DHHC domain-containing protein 22; DHHC-22; zDHHC22."
    }, 
    "publication": [
        {
            "title": "CCN3 secretion is regulated by palmitoylation via ZDHHC22.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/29287726", 
            "journal": "Biochemical and biophysical research communications", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
                    "id": "NP_001074412.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A0PK84/publications", 
                    "id": "A0PK84", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kim Y, Yang H, Min JK, Park YJ, Jeong SH, Jang SW, Shim S", 
            "date": "2018", 
            "pmid": "29287726"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84#A0PK84-1", 
            "isoform_ac": "A0PK84-1", 
            "locus": {
                "end_pos": 86983384, 
                "start_pos": 86988676, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000222543", 
                        "id": "ENSMUST00000222543", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152660", 
                        "id": "ENSMUSP00000152660", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0PK84-1|ZDH22_MOUSE Isoform 1 of Palmitoyltransferase ZDHHC22  OS=Mus musculus OX=10090 GN=Zdhhc22 PE=1 SV=1 CANONICAL=A0PK84-1", 
                "length": 263, 
                "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYVLVIQNSPDDLGTCQGTMSQRPQCPPPSTHFCRVCSRVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGMAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:238331", 
            "resource": "KEGG Pathway", 
            "id": "mmu:238331", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84#function", 
            "annotation": "Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (PubMed:29287726).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PK84#function", 
                    "id": "A0PK84", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
            "annotation": "Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
                    "id": "NP_001074412.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8N966-1", 
            "protein_name": "Palmitoyltransferase ZDHHC22; 2.3.1.225; Zinc finger DHHC domain-containing protein 22; DHHC-22; zDHHC22.", 
            "sequence": {
                "length": 263, 
                "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPAAARLFSPALLHGALFLFLSANALGNYVLVIQNSPDDLGACQGASARKTPCPSPSTHFCRVCARVTLRHDHHCFFTGNCIGSRNMRNFVLFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSEMFVILMLYLWFAIGLACAGFCCHQLLLILRGQTRHQVRKGVAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGSESSKQQDK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/45486", 
                    "id": "45486", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q2TGI8-1", 
            "protein_name": "Palmitoyltransferase ZDHHC22; 2.3.1.225; Zinc finger DHHC domain-containing protein 22; DHHC-22; zDHHC22.", 
            "sequence": {
                "length": 263, 
                "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYILVVQNSPDDLGACQGTSSQRPQRPPPSTHFCRVCARVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGVAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/45486", 
                    "id": "45486", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
        "ac": "NP_001074412.1", 
        "name": "palmitoyltransferase ZDHHC22; putative palmitoyltransferase ZDHHC22; DHHC-22; zinc finger DHHC domain-containing protein 22.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein-cysteine S-palmitoyltransferase activity", 
                        "id": "GO:0019706"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum", 
                        "id": "GO:0005783"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi apparatus", 
                        "id": "GO:0005794"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein localization to plasma membrane", 
                        "id": "GO:0072659"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein targeting to membrane", 
                        "id": "GO:0006612"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018345", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein palmitoylation", 
                        "id": "GO:0018345"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018230", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidyl-L-cysteine S-palmitoylation", 
                        "id": "GO:0018230"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
            "id": "NP_001074412.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:238331", 
            "id": "mmu:238331", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048483", 
            "id": "ENSMUSG00000048483", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LPSMRQD/", 
            "id": "LPSMRQD", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001594", 
            "id": "IPR001594", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", 
            "id": "IPR000731", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01529", 
            "id": "PF01529", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0PK84", 
            "id": "PR_A0PK84", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/238331", 
            "id": "238331", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2685108", 
            "id": "2685108", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0PK84", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 29318.0, 
        "chemical_mass": 29318.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "name": "Zdhhc22; Gm262.", 
            "locus": {
                "end_pos": 86980763, 
                "start_pos": 86990430, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000048483", 
                        "id": "ENSMUSG00000048483", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}