{
    "uniprot_canonical_ac": "A0PJW8-1", 
    "sequence": {
        "header": "sp|A0PJW8-1|DAPL1_HUMAN Isoform 1 of Death-associated protein-like 1  OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=2 CANONICAL=A0PJW8-1", 
        "length": 107, 
        "sequence": "MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC"
    }, 
    "uniprot_id": "DAPL1_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "death-associated protein-like 1", 
                "early epithelial differentiation-associated protein"
            ], 
            "uniprotkb": [
                "Death-associated protein-like 1", 
                "Early epithelial differentiation-associated protein"
            ]
        }, 
        "gene": {
            "refseq": [
                "DAPL1"
            ], 
            "uniprotkb": [
                "DAPL1", 
                "EEDA"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Death-associated protein-like 1; Early epithelial differentiation-associated protein."
    }, 
    "publication": [
        {
            "title": "Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death-associated protein like-1 DAPL1 by alternative MITF splice forms.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/29171181", 
            "journal": "Pigment cell & melanoma research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ma X, Hua J, Zheng G, Li F, Rao C, Li H, Wang J, Pan L, Hou L", 
            "date": "2018", 
            "pmid": "29171181"
        }, 
        {
            "title": "DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28334846", 
            "journal": "Human molecular genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ma X, Li H, Wang Y, Wang J, Zheng Q, Hua J, Yang J, Pan L, Lu F, Qu J, Hou L", 
            "date": "2017", 
            "pmid": "28334846"
        }, 
        {
            "title": "A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/25680934", 
            "journal": "Neuromolecular medicine", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Grassmann F, Friedrich U, Fauser S, Schick T, Milenkovic A, Schulz HL, von Strachwitz CN, Bettecken T, Lichtner P, Meitinger T, Arend N, Wolf A, Haritoglou C, Rudolph G, Chakravarthy U, Silvestri G, McKay GJ, Freitag-Wolf S, Krawczak M, Smith RT, Merriam JC, Merriam JE, Allikmets R, Heid IM, Weber BH", 
            "date": "2015", 
            "pmid": "25680934"
        }, 
        {
            "title": "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20800603", 
            "journal": "Mutation research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanche H, Schreiber S, Nebel A", 
            "date": "2010", 
            "pmid": "20800603"
        }, 
        {
            "title": "EEDA: a protein associated with an early stage of stratified epithelial differentiation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15920738", 
            "journal": "J. Cell. Physiol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PJW8/publications", 
                    "id": "A0PJW8", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Sun L., Zhou M., Lavker R.M., Ryan D.G., Sun T.-T.", 
            "date": "2006", 
            "pmid": "15920738"
        }, 
        {
            "title": "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12107413", 
            "journal": "Molecular vision", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K", 
            "date": "2002", 
            "pmid": "12107413"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 105, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.6", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "162", 
            "end_pos": 105, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 105, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.4", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "363", 
                "url": "http://disease-ontology.org/term/DOID:363", 
                "icd10": "", 
                "name": "Uterine cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "558", 
            "end_pos": 105, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 105, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "11934", 
                "url": "http://disease-ontology.org/term/DOID:11934", 
                "icd10": "", 
                "name": "Head and neck cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "980", 
            "end_pos": 105, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PJW8#A0PJW8-1", 
            "isoform_ac": "A0PJW8-1", 
            "locus": {
                "end_pos": 158795373, 
                "start_pos": 158815818, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000309950", 
                        "id": "ENST00000309950", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000309538", 
                        "id": "ENSP00000309538", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0PJW8-1|DAPL1_HUMAN Isoform 1 of Death-associated protein-like 1  OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=2 CANONICAL=A0PJW8-1", 
                "length": 107, 
                "sequence": "MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PJW8#B8ZZC6-1", 
            "isoform_ac": "B8ZZC6-1", 
            "locus": {
                "end_pos": 158795373, 
                "start_pos": 158853633, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000409042", 
                        "id": "ENST00000409042", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000386422", 
                        "id": "ENSP00000386422", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|B8ZZC6-1|DAPL1_HUMAN Computationally mapped isoform of Death-associated protein-like 1  OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=1 CANONICAL=A0PJW8-1", 
                "length": 113, 
                "sequence": "MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKEQVQLGVRNERQVQPFHHGCSWKETSGFDTRCPRHTEPRNLTGV"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PJW8#H0Y3U5-1", 
            "isoform_ac": "H0Y3U5-1", 
            "locus": {
                "end_pos": 158804298, 
                "start_pos": 158862705, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000343761", 
                        "id": "ENST00000343761", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000385306", 
                        "id": "ENSP00000385306", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|H0Y3U5-1|DAPL1_HUMAN Computationally mapped isoform of Death-associated protein-like 1  OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=1 CANONICAL=A0PJW8-1", 
                "length": 174, 
                "sequence": "XRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKEQVQLGVRNERQVQPFHHGCSWKETSGFDTSSEDPERLFLSMCLVTVLGNLLIILAVTPDSHLHIPMYFFLSNLSLPDIGFTSTTVPKMIVDIQSHSRVISYAGCLTQMSLFAIFGGMEERHAPECDGL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PJW8#M1EA23-1", 
            "isoform_ac": "M1EA23-1", 
            "locus": {
                "end_pos": 158795373, 
                "start_pos": 158815780, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000621326", 
                        "id": "ENST00000621326", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000479872", 
                        "id": "ENSP00000479872", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|M1EA23-1|DAPL1_HUMAN Computationally mapped isoform of Death-associated protein-like 1  OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=1 CANONICAL=A0PJW8-1", 
                "length": 134, 
                "sequence": "MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKSFALFAQAGKQWSDLSSLQPPPPGFKWFSCLSLPSSWDYSSTINFQQQCTWRIKNPHLLWKRLFH"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:92196", 
            "resource": "KEGG Pathway", 
            "id": "hsa:92196", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PJW8#function", 
            "annotation": "May play a role in the early stages of epithelial differentiation or in apoptosis.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PJW8#function", 
                    "id": "A0PJW8", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
            "annotation": "Human retinal pigment epithelium (RPE) cell lines that the pigment cell transcription factor MITF regulates RPE cell proliferation by upregulating DAPL1 expression.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
            "annotation": "Authors show that DAPL1 is a novel regulator of RPE cell proliferation that is important for the maintenance of the RPE as a monolayer. The findings suggest that DAPL1 dysregulation may be involved in abnormal RPE-related proliferative diseases and corresponding retinal dysfunctions in humans.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
            "annotation": "DAPL1 plays a role in epithelial differentiation and may be involved in apoptotic processes thereby suggesting a possible novel pathway in AMD pathogenesis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
            "annotation": "Observational study of gene-disease association. (HuGE Navigator)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
                    "id": "NP_001017920.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "F7FMI3-1", 
            "protein_name": "Death-associated protein-like 1.", 
            "sequence": {
                "length": 128, 
                "sequence": "MGQLQLALSLRAPTRHWHTDTMANEVQVLSSPLKGRHAPAVKAGGMRISKKQEMGVLERHTKKTGLEKTSAITNVAKIQMLDTLTDTLDKLHHKFPATVHTAHQKPTPALEKAAPLKRAYIIQQPRKC"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0PJW8/", 
                    "id": "A0PJW8", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9D757-1", 
            "protein_name": "Death-associated protein-like 1; Early epithelial differentiation-associated protein.", 
            "sequence": {
                "length": 107, 
                "sequence": "MANEVQVLPSPLKGRYAPAVKAGGMRISKKQEMGVLERHTKKTGLEKTSAITNVAKIQMLDALTDTLDKLNHKFPATVHTAHQKPTPALEKAAPMKRAYIIQQPRKC"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0PJW8/", 
                    "id": "A0PJW8", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/18947", 
                    "id": "18947", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
        "ac": "NP_001017920.2", 
        "name": "death-associated protein-like 1; early epithelial differentiation-associated protein.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070513", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PJW8", 
                                "id": "A0PJW8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "death domain binding", 
                        "id": "GO:0070513"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097190", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PJW8", 
                                "id": "A0PJW8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "apoptotic signaling pathway", 
                        "id": "GO:0097190"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010507", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PJW8", 
                                "id": "A0PJW8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of autophagy", 
                        "id": "GO:0010507"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PJW8", 
                                "id": "A0PJW8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to amino acid starvation", 
                        "id": "GO:0034198"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PJW8", 
                                "id": "A0PJW8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell differentiation", 
                        "id": "GO:0030154"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017920.2", 
            "id": "NP_001017920.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=21490", 
            "id": "21490", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A0PJW8", 
            "id": "A0PJW8", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0PJW8", 
            "id": "NX_A0PJW8", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=DAPL1", 
            "id": "DAPL1", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:92196", 
            "id": "hsa:92196", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163331", 
            "id": "ENSG00000163331", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SHDFPET/", 
            "id": "SHDFPET", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024130", 
            "id": "IPR024130", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15228", 
            "id": "PF15228", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13177", 
            "id": "PTHR13177", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0PJW8", 
            "id": "PR_A0PJW8", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A0PJW8*", 
            "id": "A0PJW8", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/92196", 
            "id": "92196", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJW8", 
                    "id": "A0PJW8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
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        "chemical_mass": 11880.0
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}