{ "uniprot_canonical_ac": "A0PJK1-1", "sequence": { "header": "sp|A0PJK1-1|SC5AA_HUMAN Isoform 1 of Sodium/glucose cotransporter 5 OS=Homo sapiens OX=9606 GN=SLC5A10 PE=1 SV=2 CANONICAL=A0PJK1-1", "length": 596, "sequence": "MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA" }, "uniprot_id": "SC5AA_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "sodium/glucose cotransporter 5 isoform 2", "sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; solute carrier family 5 (sodium/sugar cotransporter), member 10; solute carrier family 5 (sodium/glucose cotransporter), member 10" ], "uniprotkb": [ "Sodium/glucose cotransporter 5", "Na(+)/glucose cotransporter 5", "Solute carrier family 5 member 10" ] }, "gene": { "refseq": [ "SLC5A10", "SGLT-5", "SGLT5" ], "uniprotkb": [ "SLC5A10", "SGLT5", "SGLT-5" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; Solute carrier family 5 member 10.", "short": "Na(+)/glucose cotransporter 5" }, "publication": [ { "title": "Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30281872", "journal": "Cancer science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ], "authors": "Hong MJ, Yoo SS, Choi JE, Kang HG, Do SK, Lee JH, Lee WK, Lee J, Lee SY, Cha SI, Kim CH, Lee EB, Cho S, Jheon S, Park JY", "date": "2018", "pmid": "30281872" }, { "title": "Fingerprints of hSGLT5 sugar and cation selectivity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24573086", "journal": "American journal of physiology. Cell physiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ], "authors": "Ghezzi C, Gorraitz E, Hirayama BA, Loo DD, Grempler R, Mayoux E, Wright EM", "date": "2014", "pmid": "24573086" }, { "title": "Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22212718", "journal": "FEBS letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0PJK1/publications", "id": "A0PJK1", "database": "UniProtKB" } ], "authors": "Grempler R, Augustin R, Froehner S, Hildebrandt T, Simon E, Mark M, Eickelmann P", "date": "2012", "pmid": "22212718" }, { "title": "Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22127746", "journal": "Diabetes therapy : research, treatment and education of diabetes and related disorders", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ], "authors": "Chen J, Williams S, Ho S, Loraine H, Hagan D, Whaley JM, Feder JN", "date": "2010", "pmid": "22127746" }, { "title": "A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19237446", "journal": "Bioinformatics (Oxford, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ], "authors": "Lynn KS, Li LL, Lin YJ, Wang CH, Sheng SH, Lin JH, Liao W, Hsu WL, Pan WH", "date": "2009", "pmid": "19237446" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 4, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 96, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [ { "start_pos": 315, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJK1", "id": "A0PJK1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "I", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 315, "type": "Point mutation" }, { "start_pos": 404, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJK1", "id": "A0PJK1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "S", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "P", "subjects_tested": "50", "end_pos": 404, "type": "Point mutation" }, { "start_pos": 408, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJK1", "id": "A0PJK1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "E", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 408, "type": "Point mutation" }, { "start_pos": 472, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJK1", "id": "A0PJK1", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%).", "sequence_org": "A", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "S", "subjects_tested": "103", "end_pos": 472, "type": "Point mutation" }, { "start_pos": 422, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJK1", "id": "A0PJK1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 422, "type": "Point mutation" }, { "start_pos": 201, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJK1", "id": "A0PJK1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "L", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "P", "subjects_tested": "50", "end_pos": 201, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1#A0PJK1-1", "isoform_ac": "A0PJK1-1", "locus": { "end_pos": 18952206, "start_pos": 19020428, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000395645", "id": "ENST00000395645", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000379007", "id": "ENSP00000379007", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJK1-1|SC5AA_HUMAN Isoform 1 of Sodium/glucose cotransporter 5 OS=Homo sapiens OX=9606 GN=SLC5A10 PE=1 SV=2 CANONICAL=A0PJK1-1", "length": 596, "sequence": "MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA" } }, { "url": "https://www.uniprot.org/uniprot/A0PJK1#A0PJK1-2", "isoform_ac": "A0PJK1-2", "locus": { "end_pos": 18952206, "start_pos": 19020428, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000395643", "id": "ENST00000395643", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000379005", "id": "ENSP00000379005", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJK1-2|SC5AA_HUMAN Isoform 2 of Sodium/glucose cotransporter 5 OS=Homo sapiens OX=9606 GN=SLC5A10 PE=1 SV=2 CANONICAL=A0PJK1-1", "length": 569, "sequence": "MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA" } }, { "url": "https://www.uniprot.org/uniprot/A0PJK1#A0PJK1-3", "isoform_ac": "A0PJK1-3", "locus": { "end_pos": 18958739, "start_pos": 19020428, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000317977", "id": "ENST00000317977", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000324346", "id": "ENSP00000324346", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJK1-3|SC5AA_HUMAN Isoform 3 of Sodium/glucose cotransporter 5 OS=Homo sapiens OX=9606 GN=SLC5A10 PE=1 SV=2 CANONICAL=A0PJK1-1", "length": 566, "sequence": "MTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPGAHVYEERHQVSVSRTDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRTGIPSTPPAPQSRLSFLLPETPPLERYLLGLVVMDLWLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA" } }, { "url": "https://www.uniprot.org/uniprot/A0PJK1#A0PJK1-4", "isoform_ac": "A0PJK1-4", "locus": { "end_pos": 18952206, "start_pos": 19020428, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000395647", "id": "ENST00000395647", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000379008", "id": "ENSP00000379008", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJK1-4|SC5AA_HUMAN Isoform 4 of Sodium/glucose cotransporter 5 OS=Homo sapiens OX=9606 GN=SLC5A10 PE=1 SV=2 CANONICAL=A0PJK1-1", "length": 612, "sequence": "MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPGAHVYEERHQVSVSRTDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA" } }, { "url": "https://www.uniprot.org/uniprot/A0PJK1#A0PJK1-5", "isoform_ac": "A0PJK1-5", "locus": { "end_pos": 18952206, "start_pos": 19020428, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000417251", "id": "ENST00000417251", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000401875", "id": "ENSP00000401875", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJK1-5|SC5AA_HUMAN Isoform 5 of Sodium/glucose cotransporter 5 OS=Homo sapiens OX=9606 GN=SLC5A10 PE=1 SV=2 CANONICAL=A0PJK1-1", "length": 560, "sequence": "MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:125206", "resource": "KEGG Pathway", "id": "hsa:125206", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-189200", "resource": "Reactome", "id": "R-HSA-189200", "name": "Cellular hexose transport" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1#function", "annotation": "High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1#function", "id": "A0PJK1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "annotation": "Results show that rs2257609 C>T is located in the intron region of SLC5A10 and is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients. The rs2257609 C>T variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "annotation": "HSGLT5 is a sodium/mannose transporter that is blocked by phlorizin. Li(+) and H(+) ions were also able to drive mannose transport, and transport was electrogenic.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "annotation": "SGLT-5 as a kidney mannose transporter", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5SWY8-1", "protein_name": "Sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; Solute carrier family 5 member 10.", "sequence": { "length": 596, "sequence": "MAGNSTGDAHVPGSQLSVTDIIVISVYFALNVAVGIWSACRANKNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFVGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRFGGQRIRTYLSVLSLMLSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLATVIYTDALQTIIMVVGAVILAVKAFNQIGGYEQLEAAYAQAIPSRTIPNTTCHLPRADAMHMFRDPSTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPGMISRVLFPDDVGCVVPSECLRACGAEIGCSNIAYPKLVMELMPIGLRGLMIAVMMAALLSSLTSIFNSSSTLFTMDIWRQLRPSAGERELLLVGRLVIVVLIGVSVAWIPVLQGSNSGQLFIYMQSVTSSLAPPVTAIFILGIFWRRANEQGAFWGLMAGLVVGALRLVLEFLYPEPPCGQIDTRPAPLRSLHYLHFAIALFLLTCAVMAAGSLLSPPPQQRQIENLTWWTLAPNWSLGTKTGDGQTPQKRAFWARVCNVNAIFLMCVNIFFYAYFA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/65037", "id": "65037", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "G3V8X5-1", "protein_name": "Solute carrier family 5 member 10.", "sequence": { "length": 598, "sequence": "MADNSTGDIHAPGSQLSTSDIIVISLYFALNVAVGVWTACRANKNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYVSSEIVTLPEYIQKRFGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLATVIYTDALQTAIMVVGAVILAVKAFNQIGGYEQLEAAYAQATPSRTIPNTTCHLPRADAMHMFRDPSTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPGMISRVLFPDDVGCVVPSECLRACGAEIGCSNIAYPKLVMELMPIGLRGLMIAVMMAALLSSLTSIFNSSSTLFTMDIWRQFRPGAGERELLLVGRLVIVVLVGVSVAWIPVLQGSNSGQLFIYMQSVTSSLAPPVTAIFLLGIFWRRANEQGAFWGLMAGLLVGALRLVLEFLYPEPHCGQIDTRPFPLGSIHYLHFAIALFFLTCAVMAAGSLLSPPPQQRQIENLTWWTLDPNWSLRTKTGGSFKSSGPPSFLGWTWRPQEAECAHRYTVGQYQVSD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/65037", "id": "65037", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "ac": "NP_001035915.1", "name": "sodium/glucose cotransporter 5 isoform 2; sodium/glucose cotransporter 5; Na(+)/glucose cotransporter 5; solute carrier family 5 (sodium/sugar cotransporter), member 10; solute carrier family 5 (sodium/glucose cotransporter), member 10.", "summary": "This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005412", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "glucose:sodium symporter activity", "id": "GO:0005412" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015370", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "solute:sodium symporter activity", "id": "GO:0015370" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "extracellular exosome", "id": "GO:0070062" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "extracellular exosome", "id": "GO:0070062" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008645", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "id": "A0PJK1", "database": "UniProtKB" } ], "name": "hexose transmembrane transport", "id": "GO:0008645" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 6, "annotation": "n_glycosylation_sequon", "start_pos": 4 }, { "end_pos": 98, "annotation": "n_glycosylation_sequon", "start_pos": 96 }, { "end_pos": 241, "annotation": "n_glycosylation_sequon", "start_pos": 239 }, { "end_pos": 388, "annotation": "n_glycosylation_sequon", "start_pos": 386 }, { "end_pos": 547, "annotation": "n_glycosylation_sequon", "start_pos": 545 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035915.1", "id": "NP_001035915.1", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=23155", "id": "23155", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A0PJK1", "id": "A0PJK1", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A0PJK1", "id": "NX_A0PJK1", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC5A10", "id": "SLC5A10", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-189200", "id": "R-HSA-189200", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:125206", "id": "hsa:125206", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/CWTDLIQ/", "id": "CWTDLIQ", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018212", "id": "IPR018212", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001734", "id": "IPR001734", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038377", "id": "IPR038377", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00474", "id": "PF00474", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0PJK1", "id": "PR_A0PJK1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/125206", "id": "125206", "database": "GeneID" } ], "expression_disease": [ { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJK1", "id": "A0PJK1", "database": "BioXpress" } ] } ], "uniprot_ac": "A0PJK1", "disease": [], "mass": { "monoisotopic_mass": 64342.0, "chemical_mass": 64342.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000154025", "id": "ENSG00000154025", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0PJK1", "name": "SLC5A10; SGLT5; SGLT-5.", "locus": { "end_pos": 19022595, "start_pos": 18950345, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000154025", "id": "ENSG00000154025", "database": "Ensembl Gene" } ] } } ] }