{ "uniprot_canonical_ac": "A0JPQ4-1", "sequence": { "header": "sp|A0JPQ4-1|TRI72_RAT Isoform 1 of Tripartite motif-containing protein 72 OS=Rattus norvegicus OX=10116 GN=Trim72 PE=1 SV=1 CANONICAL=A0JPQ4-1", "length": 477, "sequence": "MSTAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPADDGTVACPCCQASTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKAQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGEAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPELEELTFDPSSAHPSLVVSASGRRVECSEQKAPPAGEDTCQFDKTVAVVAKQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLTFYDASNTDALTPLFSFHERLPGPVYPMFDVCWHDKGKNSQPLLLVGPDSEQA" }, "uniprot_id": "TRI72_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "tripartite motif-containing protein 72", "mg53; mitsugumin-53; tripartite motif containing 72, E3 ubiquitin protein ligase" ], "uniprotkb": [ "Tripartite motif-containing protein 72", "Mitsugumin-53", "Mg53" ] }, "gene": { "refseq": [ "Trim72", "RGD1562778" ], "uniprotkb": [ "Trim72", "Mg53", "RGD1562778" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Tripartite motif-containing protein 72; Mitsugumin-53; Mg53." }, "publication": [ { "title": "Potential role of MG53 in the regulation of transforming-growth-factor-beta1-induced atrial fibrosis and vulnerability to atrial fibrillation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29233682", "journal": "Experimental cell research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Guo J, Jia F, Jiang Y, Li Q, Yang Y, Xiao M, Xiao H", "date": "2018", "pmid": "29233682" }, { "title": "Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26790476", "journal": "Cardiovascular research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Lemckert FA, Bournazos A, Eckert DM, Kenzler M, Hawkes JM, Butler TL, Ceely B, North KN, Winlaw DS, Egan JR, Cooper ST", "date": "2016", "pmid": "26790476" }, { "title": "Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27843952", "journal": "Journal of diabetes research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Qi J, Yang B, Ren C, Fu J, Zhang J", "date": "2016", "pmid": "27843952" }, { "title": "Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26306047", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Li H, Duann P, Lin PH, Zhao L, Fan Z, Tan T, Zhou X, Sun M, Fu M, Orange M, Sermersheim M, Ma H, He D, Steinberg SM, Higgins R, Zhu H, John E, Zeng C, Guan J, Ma J", "date": "2015", "pmid": "26306047" }, { "title": "MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23965929", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Yi JS, Park JS, Ham YM, Nguyen N, Lee NR, Hong J, Kim BW, Lee H, Lee CS, Jeong BC, Song HK, Cho H, Kim YK, Lee JS, Park KS, Shin H, Choi I, Lee SH, Park WJ, Park SY, Choi CS, Lin P, Karunasiri M, Tan T, Duann P, Zhu H, Ma J, Ko YG", "date": "2013", "pmid": "23965929" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4/publications", "id": "A0JPQ4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "MG53 constitutes a primary determinant of cardiac ischemic preconditioning.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20516375", "journal": "Circulation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP", "date": "2010", "pmid": "20516375" }, { "title": "MG53 nucleates assembly of cell membrane repair machinery.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19043407", "journal": "Nature cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, Ko JK, Lin P, Thornton A, Zhao X, Pan Z, Komazaki S, Brotto M, Takeshima H, Ma J", "date": "2009", "pmid": "19043407" }, { "title": "MG53 regulates membrane budding and exocytosis in muscle cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19029292", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cai C, Masumiya H, Weisleder N, Pan Z, Nishi M, Komazaki S, Takeshima H, Ma J", "date": "2009", "pmid": "19029292" }, { "title": "Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19380584", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cai C, Weisleder N, Ko JK, Komazaki S, Sunada Y, Nishi M, Takeshima H, Ma J", "date": "2009", "pmid": "19380584" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4#A0JPQ4-1", "isoform_ac": "A0JPQ4-1", "locus": { "end_pos": 199450563, "start_pos": 199457092, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000029994", "id": "ENSRNOT00000029994", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000030976", "id": "ENSRNOP00000030976", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0JPQ4-1|TRI72_RAT Isoform 1 of Tripartite motif-containing protein 72 OS=Rattus norvegicus OX=10116 GN=Trim72 PE=1 SV=1 CANONICAL=A0JPQ4-1", "length": 477, "sequence": "MSTAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPADDGTVACPCCQASTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKAQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGEAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPELEELTFDPSSAHPSLVVSASGRRVECSEQKAPPAGEDTCQFDKTVAVVAKQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLTFYDASNTDALTPLFSFHERLPGPVYPMFDVCWHDKGKNSQPLLLVGPDSEQA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:365377", "resource": "KEGG Pathway", "id": "rno:365377", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445355", "resource": "Reactome", "id": "R-RNO-445355", "name": "Smooth Muscle Contraction" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4#function", "annotation": "Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4#function", "id": "A0JPQ4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "This suggests that MG53 is a potential regulator of atrial fibrosis induced by the TGF-beta1/Smad pathway in patients with atrial fibrillation .", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "MG53 is an effective biomarker of myocardial injury and dysfunction in murine hearts. However, MG53 is not expressed in human heart and therefore does not hold utility as a clinical biomarker of myocardial injury", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "These results suggest that an 8-week swimming exercise improves HFD-induced insulin resistance maybe through a reduction of TRIM72 in skeletal muscle and enhancement of AKT signal transduction.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "MG53 is a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "MG53, a member of the muscle-specific transmembrane adaptor molecule (TRIM) protein family, is a crucial component of the cardiac ischemic preconditioning response.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q1XH17-1", "protein_name": "Tripartite motif-containing protein 72; Mitsugumin-53; Mg53.", "sequence": { "length": 477, "sequence": "MSAAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPAADGTVACPCCQAPTRPQALSTNLQLSRLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAQARLKTQLPQQKMQLQEACMRKEKTVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGDAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSDQKAPPAGEDTRQFDKAVAVVAQQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLAFYDASNPDVLTPIFSFHERLPGPVYPIFDVCWHDKGKNAQPLLLVGPEQEQA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66924", "id": "66924", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0JPQ4/", "id": "A0JPQ4", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6ZMU5-1", "protein_name": "Tripartite motif-containing protein 72; Mitsugumin-53; Mg53.", "sequence": { "length": 477, "sequence": "MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQVWRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAEA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66924", "id": "66924", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0JPQ4/", "id": "A0JPQ4", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "ac": "NP_001071143.1", "name": "tripartite motif-containing protein 72; mg53; mitsugumin-53; tripartite motif containing 72, E3 ubiquitin protein ligase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "phosphatidylserine binding", "id": "GO:0001786" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle membrane", "id": "GO:0030659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "sarcolemma", "id": "GO:0042383" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001778", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "plasma membrane repair", "id": "GO:0001778" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "protein homooligomerization", "id": "GO:0051260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "muscle organ development", "id": "GO:0007517" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "exocytosis", "id": "GO:0006887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010832", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "negative regulation of myotube differentiation", "id": "GO:0010832" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003012", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "muscle system process", "id": "GO:0003012" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043569", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "negative regulation of insulin-like growth factor receptor signaling pathway", "id": "GO:0043569" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445355", "id": "R-RNO-445355", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:365377", "id": "rno:365377", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022099", "id": "ENSRNOG00000022099", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/CQFDKAV/", "id": "CQFDKAV", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00021", "id": "cd00021", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "id": "IPR013320", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": "IPR001841", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "id": "IPR001870", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "id": "IPR003877", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "id": "IPR017907", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "id": "IPR003879", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "id": "IPR006574", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "id": "IPR000315", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "id": "IPR027370", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035038", "id": "IPR035038", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00622", "id": "PF00622", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13765", "id": "PF13765", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00643", "id": "PF00643", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13445", "id": "PF13445", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103:SF11", "id": "PTHR24103:SF11", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPQ4", "id": "PR_A0JPQ4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/365377", "id": "365377", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562778", "id": "1562778", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0JPQ4", "disease": [], "mass": { "monoisotopic_mass": 52832.0, "chemical_mass": 52832.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "name": "Trim72; Mg53; RGD1562778.", "locus": { "end_pos": 199457895, "start_pos": 199449973, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000022099", "id": "ENSRNOG00000022099", "database": "Ensembl Gene" } ] } } ] }