{
    "uniprot_canonical_ac": "A0JPP7-1", 
    "sequence": {
        "header": "sp|A0JPP7-1|DDI1_RAT Isoform 1 of Protein DDI1 homolog 1  OS=Rattus norvegicus OX=10116 GN=Ddi1 PE=1 SV=1 CANONICAL=A0JPP7-1", 
        "length": 408, 
        "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGPRPPGRAPNHPRTDFTGSGSAVPGTSSSRHPHPHQHHHHQHQRIPSTQQAHGLASGENMAFAQDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLVEQQRERAMREQEMFRLYSADPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGAVQEDSSDKEVAGSIKHPVKGPGRKKH"
    }, 
    "uniprot_id": "DDI1_RAT", 
    "enzyme_annotation": [
        {
            "ec": "3.4.23.-", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "protein DDI1 homolog 1"
            ], 
            "uniprotkb": [
                "Protein DDI1 homolog 1", 
                "3.4.23.-"
            ]
        }, 
        "gene": {
            "refseq": [
                "Ddi1", 
                "RGD1559430"
            ], 
            "uniprotkb": [
                "Ddi1", 
                "RGD1559430"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP7", 
                    "id": "A0JPP7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Protein DDI1 homolog 1; 3.4.23.-."
    }, 
    "publication": [
        {
            "title": "Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/29290612", 
            "journal": "Molecular cell", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944.1", 
                    "id": "NP_001078944.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kottemann MC, Conti BA, Lach FP, Smogorzewska A", 
            "date": "2018", 
            "pmid": "29290612"
        }, 
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP7/publications", 
                    "id": "A0JPP7", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012", 
            "pmid": "22673903"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP7#A0JPP7-1", 
            "isoform_ac": "A0JPP7-1", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A0JPP7-1|DDI1_RAT Isoform 1 of Protein DDI1 homolog 1  OS=Rattus norvegicus OX=10116 GN=Ddi1 PE=1 SV=1 CANONICAL=A0JPP7-1", 
                "length": 408, 
                "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGPRPPGRAPNHPRTDFTGSGSAVPGTSSSRHPHPHQHHHHQHQRIPSTQQAHGLASGENMAFAQDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLVEQQRERAMREQEMFRLYSADPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGAVQEDSSDKEVAGSIKHPVKGPGRKKH"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:367012", 
            "resource": "KEGG Pathway", 
            "id": "rno:367012", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP7#function", 
            "annotation": "Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP7#function", 
                    "id": "A0JPP7", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9DAF3-1", 
            "protein_name": "Protein DDI1 homolog 1; 3.4.23.-.", 
            "sequence": {
                "length": 408, 
                "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGLRTPGRTPNHPRADFTGSGSAVPGTSSSRHPHQHQHHYHHHQRIPSTQQAHGLASGENMTFAQELDSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLMEQQRERTLREQEMFRLYSTNPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWGGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGTVQEESSDREVGGTIKHPVKGPGRKKH"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/100549", 
                    "id": "100549", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q8WTU0-1", 
            "protein_name": "Protein DDI1 homolog 1; 3.4.23.-.", 
            "sequence": {
                "length": 396, 
                "sequence": "MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/100549", 
                    "id": "100549", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944.1", 
        "ac": "NP_001078944.1", 
        "name": "protein DDI1 homolog 1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP7", 
                                "id": "A0JPP7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "aspartic-type endopeptidase activity", 
                        "id": "GO:0004190"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP7", 
                                "id": "A0JPP7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of protein stability", 
                        "id": "GO:0031647"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP7", 
                                "id": "A0JPP7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasomal protein catabolic process", 
                        "id": "GO:0010498"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097752", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP7", 
                                "id": "A0JPP7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of DNA stability", 
                        "id": "GO:0097752"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072711", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP7", 
                                "id": "A0JPP7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to hydroxyurea", 
                        "id": "GO:0072711"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944.1", 
            "id": "NP_001078944.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:367012", 
            "id": "rno:367012", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05479", 
            "id": "cd05479", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019103", 
            "id": "IPR019103", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", 
            "id": "IPR029071", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", 
            "id": "IPR000626", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR021109", 
            "id": "IPR021109", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF09668", 
            "id": "PF09668", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00240", 
            "id": "PF00240", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPP7", 
            "id": "PR_A0JPP7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/367012", 
            "id": "367012", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559430", 
            "id": "1559430", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0JPP7", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 45451.0, 
        "chemical_mass": 45451.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP7", 
            "name": "Ddi1; RGD1559430.", 
            "locus": {
                "end_pos": 4547725, 
                "start_pos": 4549573, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000022081", 
                        "id": "ENSRNOG00000022081", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}