{
    "uniprot_canonical_ac": "A0JPP4-1", 
    "sequence": {
        "header": "sp|A0JPP4-1|SPESP_RAT Isoform 1 of Sperm equatorial segment protein 1  OS=Rattus norvegicus OX=10116 GN=Spesp1 PE=2 SV=1 CANONICAL=A0JPP4-1", 
        "length": 409, 
        "sequence": "MKPVVLVALLWLWPSSFLAYPTATVLPDEEQNLNHYVQILQNLIMSVPTKEQGFGRKFRSSRTVDGAEARSLSSEMLLTPGLVSAQEVTTPETEVMLTSMVEKTTFPSSGFTMESEKRRTHSKAFWSIQPNNVSIVLHTEEPYIEKEPEPEPELETEEESRRLATEPEPEPESESAPETETRQTAESEEEVETSTAQNKVRTGTSRMSTVITQTTNTQGTPNTVTVKTINNLDVSTESEDVPQLSGQSEILNVEDLPGHHSLSTRHENILRKISNINSQIHQGLLSDHSSPAYKEFIKASREHLKRSLALAAAAEHKLQQMYGSNVFLDGHTSDPDDDMEVIINMLYNSRSKLSDYFTINHVPSELREKATVVIAVLKKILCVDQVEMQSLIRKLLSNNMKILNILNVP"
    }, 
    "uniprot_id": "SPESP_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "sperm equatorial segment protein 1 precursor"
            ], 
            "uniprotkb": [
                "Sperm equatorial segment protein 1"
            ]
        }, 
        "gene": {
            "refseq": [
                "Spesp1", 
                "RGD1563468"
            ], 
            "uniprotkb": [
                "Spesp1", 
                "RGD1563468"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                    "id": "A0JPP4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Sperm equatorial segment protein 1."
    }, 
    "publication": [
        {
            "title": "Dynamic Changes in Equatorial Segment Protein 1 (SPESP1) Glycosylation During Mouse Spermiogenesis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/25761597", 
            "journal": "Biology of reproduction", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071150.1", 
                    "id": "NP_001071150.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Suryavathi V, Panneerdoss S, Wolkowicz MJ, Shetty J, Sherman NE, Flickinger CJ, Herr JC", 
            "date": "2015", 
            "pmid": "25761597"
        }, 
        {
            "title": "Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20375058", 
            "journal": "Journal of cell science", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071150.1", 
                    "id": "NP_001071150.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Fujihara Y, Murakami M, Inoue N, Satouh Y, Kaseda K, Ikawa M, Okabe M", 
            "date": "2010", 
            "pmid": "20375058"
        }
    ], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                    "id": "A0JPP4", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 132, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP4#A0JPP4-1", 
            "isoform_ac": "A0JPP4-1", 
            "locus": {
                "end_pos": 67217981, 
                "start_pos": 67232148, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000049441", 
                        "id": "ENSRNOT00000049441", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000043936", 
                        "id": "ENSRNOP00000043936", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0JPP4-1|SPESP_RAT Isoform 1 of Sperm equatorial segment protein 1  OS=Rattus norvegicus OX=10116 GN=Spesp1 PE=2 SV=1 CANONICAL=A0JPP4-1", 
                "length": 409, 
                "sequence": "MKPVVLVALLWLWPSSFLAYPTATVLPDEEQNLNHYVQILQNLIMSVPTKEQGFGRKFRSSRTVDGAEARSLSSEMLLTPGLVSAQEVTTPETEVMLTSMVEKTTFPSSGFTMESEKRRTHSKAFWSIQPNNVSIVLHTEEPYIEKEPEPEPELETEEESRRLATEPEPEPESESAPETETRQTAESEEEVETSTAQNKVRTGTSRMSTVITQTTNTQGTPNTVTVKTINNLDVSTESEDVPQLSGQSEILNVEDLPGHHSLSTRHENILRKISNINSQIHQGLLSDHSSPAYKEFIKASREHLKRSLALAAAAEHKLQQMYGSNVFLDGHTSDPDDDMEVIINMLYNSRSKLSDYFTINHVPSELREKATVVIAVLKKILCVDQVEMQSLIRKLLSNNMKILNILNVP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:501010", 
            "resource": "KEGG Pathway", 
            "id": "rno:501010", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP4#function", 
            "annotation": "Involved in fertilization ability of sperm.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP4#function", 
                    "id": "A0JPP4", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6UW49-1", 
            "protein_name": "Sperm equatorial segment protein 1; SP-ESP; Equatorial segment protein; ESP; 8.", 
            "sequence": {
                "length": 350, 
                "sequence": "MKPLVLLVALLLWPSSVPAYPSITVTPDEEQNLNHYIQVLENLVRSVPSGEPGREKKSNSPKHVYSIASKGSKFKELVTHGDASTENDVLTNPISEETTTFPTGGFTPEIGKKKHTESTPFWSIKPNNVSIVLHAEEPYIENEEPEPEPEPAAKQTEAPRMLPVVTESSTSPYVTSYKSPVTTLDKSTGIGISTESEDVPQLSGETAIEKPEEFGKHPESWNNDDILKKILDINSQVQQALLSDTSNPAYREDIEASKDHLKRSLALAAAAEHKLKTMYKSQLLPVGRTSNKIDDIETVINMLCNSRSKLYEYLDIKCVPPEMREKAATVFNTLKNMCRSRRVTALLKVY"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0JPP4/", 
                    "id": "A0JPP4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/49838", 
                    "id": "49838", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q9D5A0-1", 
            "protein_name": "Sperm equatorial segment protein 1.", 
            "sequence": {
                "length": 399, 
                "sequence": "MKLVVLVALWLWPSSLLAYPTITVLPDEEQNLNHYVHILQNLIMSVPTKEQDLGKKLSSSRTVDSAEPRSLASKVLLTPGLVSAQDVTPESDVLIRPVDETTNSRTRGFTLRRRRTQSTAFWSIRPNNISVVLRTEEPFIEKEPEPELESSRLPTEPEPELEPEPEPVAESRQMSEPEEELVTSTTPNKELTGTSRISSMATQPANTQATRITVTVKTTSTMDVSTDSEDVPQLSGQSEIPSAEDLPGRHSLNTRHEDILKKISNINAEIQQGLLGGNNSPEFKEFIKASREHLKRSLALAAAAEHKLEQMYGSNVFPEGRTSDPDNDMEMIINMLYNSRSKLSDYFNIKRVPSELREKASVVNAELRKILCVDQVEMQSLIKKLLSNNMKILNILNVP"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0JPP4/", 
                    "id": "A0JPP4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/49838", 
                    "id": "49838", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071150.1", 
        "ac": "NP_001071150.1", 
        "name": "sperm equatorial segment protein 1 precursor.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                                "id": "A0JPP4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "acrosomal vesicle", 
                        "id": "GO:0001669"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                                "id": "A0JPP4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "fusion of sperm to egg plasma membrane involved in single fertilization", 
                        "id": "GO:0007342"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                                "id": "A0JPP4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "acrosome reaction", 
                        "id": "GO:0007340"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035036", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                                "id": "A0JPP4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sperm-egg recognition", 
                        "id": "GO:0035036"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                                "id": "A0JPP4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "multicellular organism development", 
                        "id": "GO:0007275"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP4", 
                                "id": "A0JPP4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "fertilization", 
                        "id": "GO:0009566"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 134, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 132
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071150.1", 
            "id": "NP_001071150.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:501010", 
            "id": "rno:501010", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000025359", 
            "id": "ENSRNOG00000025359", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TAFWSIK/", 
            "id": "TAFWSIK", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026743", 
            "id": "IPR026743", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15754", 
            "id": "PF15754", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31667", 
            "id": "PTHR31667", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPP4", 
            "id": "PR_A0JPP4", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/501010", 
            "id": "501010", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563468", 
            "id": "1563468", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0JPP4", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 45880.0, 
        "chemical_mass": 45880.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP4", 
            "name": "Spesp1; RGD1563468.", 
            "locus": {
                "end_pos": 67217802, 
                "start_pos": 67232298, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000025359", 
                        "id": "ENSRNOG00000025359", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}