{ "uniprot_canonical_ac": "A0JPN6-1", "sequence": { "header": "sp|A0JPN6-1|MED22_RAT Isoform 1 of Mediator of RNA polymerase II transcription subunit 22 OS=Rattus norvegicus OX=10116 GN=Med22 PE=2 SV=1 CANONICAL=A0JPN6-1", "length": 200, "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT" }, "uniprot_id": "MED22_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "mediator of RNA polymerase II transcription subunit 22", "surfeit locus protein 5; surfeit 5" ], "uniprotkb": [ "Mediator of RNA polymerase II transcription subunit 22", "Mediator complex subunit 22", "Surfeit locus protein 5" ] }, "gene": { "refseq": [ "Med22", "RGD1564893", "Surf5" ], "uniprotkb": [ "Med22", "Surf5", "RGD1564893" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6", "id": "A0JPN6", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; Surfeit locus protein 5." }, "publication": [ { "title": "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14638676", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147.1", "id": "NP_001071147.1", "database": "RefSeq" } ], "authors": "Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW", "date": "2004", "pmid": "14638676" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6#A0JPN6-1", "isoform_ac": "A0JPN6-1", "locus": { "end_pos": 5454218, "start_pos": 5458567, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066193", "id": "ENSRNOT00000066193", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062301", "id": "ENSRNOP00000062301", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0JPN6-1|MED22_RAT Isoform 1 of Mediator of RNA polymerase II transcription subunit 22 OS=Rattus norvegicus OX=10116 GN=Med22 PE=2 SV=1 CANONICAL=A0JPN6-1", "length": 200, "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT" } }, { "url": "https://www.uniprot.org/uniprot/A0JPN6#A0JPN6-2", "isoform_ac": "A0JPN6-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A0JPN6-2|MED22_RAT Isoform 2 of Mediator of RNA polymerase II transcription subunit 22 OS=Rattus norvegicus OX=10116 GN=Med22 PE=2 SV=1 CANONICAL=A0JPN6-1", "length": 140, "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSRYK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:100911917", "resource": "KEGG Pathway", "id": "rno:100911917", "name": "" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:499762", "resource": "KEGG Pathway", "id": "rno:499762", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6#function", "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6#function", "id": "A0JPN6", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q15528-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22; Surfeit locus protein 5; Surf-5; Mediator complex subunit 22.", "sequence": { "length": 200, "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4913", "id": "4913", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q62276-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22; Surfeit locus protein 5; Surf-5; Mediator complex subunit 22.", "sequence": { "length": 200, "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDADSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4913", "id": "4913", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147.1", "ac": "NP_001071147.1", "name": "mediator of RNA polymerase II transcription subunit 22; surfeit locus protein 5; surfeit 5.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6", "id": "A0JPN6", "database": "UniProtKB" } ], "name": "transcription coregulator activity", "id": "GO:0003712" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6", "id": "A0JPN6", "database": "UniProtKB" } ], "name": "mediator complex", "id": "GO:0016592" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6", "id": "A0JPN6", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 34, "annotation": "n_glycosylation_sequon", "start_pos": 32 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147.1", "id": "NP_001071147.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:100911917", "id": "rno:100911917", "database": "KEGG Pathway" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:499762", "id": "rno:499762", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005059", "id": "ENSRNOG00000005059", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/KQAECDQ/", "id": "KQAECDQ", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009332", "id": "IPR009332", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038427", "id": "IPR038427", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF06179", "id": "PF06179", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12434", "id": "PTHR12434", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPN6", "id": "PR_A0JPN6", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/100911917", "id": "100911917", "database": "GeneID" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/499762", "id": "499762", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564893", "id": "1564893", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0JPN6", "disease": [], "mass": { "monoisotopic_mass": 22312.0, "chemical_mass": 22312.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPN6", "name": "Med22; Surf5; RGD1564893.", "locus": { "end_pos": 5453614, "start_pos": 5458782, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000049749", "id": "ENSRNOG00000049749", "database": "Ensembl Gene" } ] } } ] }