{ "uniprot_canonical_ac": "A0JPN1-1", "sequence": { "header": "sp|A0JPN1-1|HLX_RAT Isoform 1 of H2.0-like homeobox protein OS=Rattus norvegicus OX=10116 GN=Hlx PE=2 SV=1 CANONICAL=A0JPN1-1", "length": 476, "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHQHLPQQPPTQQQQPQQQPPPPPRAGSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPTGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSASGSSFSFSSSSSLGSSNGSAGSASSLGSNCSELLPSHQPSVTSGPQSPEIAQVPLAGL" }, "uniprot_id": "HLX_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "H2.0-like homeobox protein", "homeobox protein HLX1; H2.0-like homeo box 1" ], "uniprotkb": [ "H2.0-like homeobox protein", "Homeobox protein HLX1" ] }, "gene": { "refseq": [ "Hlx", "Hlx1" ], "uniprotkb": [ "Hlx", "Hlx1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "H2.0-like homeobox protein; Homeobox protein HLX1." }, "publication": [ { "title": "Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16424184", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071142.1", "id": "NP_001071142.1", "database": "RefSeq" } ], "authors": "Mikhalkevich N, Becknell B, Caligiuri MA, Bates MD, Harvey R, Zheng WP", "date": "2006", "pmid": "16424184" }, { "title": "Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8557196", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071142.1", "id": "NP_001071142.1", "database": "RefSeq" } ], "authors": "Hentsch B, Lyons I, Li R, Hartley L, Lints TJ, Adams JM, Harvey RP", "date": "1996", "pmid": "8557196" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1#A0JPN1-1", "isoform_ac": "A0JPN1-1", "locus": { "end_pos": 102638333, "start_pos": 102643054, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000003155", "id": "ENSRNOT00000003155", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000003155", "id": "ENSRNOP00000003155", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0JPN1-1|HLX_RAT Isoform 1 of H2.0-like homeobox protein OS=Rattus norvegicus OX=10116 GN=Hlx PE=2 SV=1 CANONICAL=A0JPN1-1", "length": 476, "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHQHLPQQPPTQQQQPQQQPPPPPRAGSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPTGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSASGSSFSFSSSSSLGSSNGSAGSASSLGSNCSELLPSHQPSVTSGPQSPEIAQVPLAGL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:364069", "resource": "KEGG Pathway", "id": "rno:364069", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1#function", "annotation": "Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1#function", "id": "A0JPN1", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q61670-1", "protein_name": "H2.0-like homeobox protein; Homeobox protein HLX1.", "sequence": { "length": 476, "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAFHQHLPQQSPTQQQQPQQQPPPPPRAVSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSTSGSSFSFSSTSSLGSGNTHVGSASSLGGNCSELPSAHQPSVTSSPQSPEIAQAPLAGL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0JPN1/", "id": "A0JPN1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/7363", "id": "7363", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q14774-1", "protein_name": "H2.0-like homeobox protein; Homeobox protein HLX1; Homeobox protein HB24.", "sequence": { "length": 488, "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGDLGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0JPN1/", "id": "A0JPN1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/7363", "id": "7363", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071142.1", "ac": "NP_001071142.1", "name": "H2.0-like homeobox protein; homeobox protein HLX1; H2.0-like homeo box 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048484", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "enteric nervous system development", "id": "GO:0048484" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "liver development", "id": "GO:0001889" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "positive regulation of cell population proliferation", "id": "GO:0008284" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "regulation of transcription, DNA-templated", "id": "GO:0006355" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046622", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "positive regulation of organ growth", "id": "GO:0046622" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045627", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "positive regulation of T-helper 1 cell differentiation", "id": "GO:0045627" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045629", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "negative regulation of T-helper 2 cell differentiation", "id": "GO:0045629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "skeletal muscle tissue development", "id": "GO:0007519" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048557", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "id": "A0JPN1", "database": "UniProtKB" } ], "name": "embryonic digestive tract morphogenesis", "id": "GO:0048557" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 15, "annotation": "n_glycosylation_sequon", "start_pos": 13 }, { "end_pos": 437, "annotation": "n_glycosylation_sequon", "start_pos": 435 }, { "end_pos": 449, "annotation": "n_glycosylation_sequon", "start_pos": 447 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071142.1", "id": "NP_001071142.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:364069", "id": "rno:364069", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002309", "id": "ENSRNOG00000002309", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/CSSTGPG/", "id": "CSSTGPG", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "id": "cd00086", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "id": "IPR001356", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "id": "IPR017970", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000047", "id": "IPR000047", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "id": "IPR020479", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00046", "id": "PF00046", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPN1", "id": "PR_A0JPN1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/364069", "id": "364069", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311961", "id": "1311961", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0JPN1", "disease": [], "mass": { "monoisotopic_mass": 50027.0, "chemical_mass": 50027.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPN1", "name": "Hlx; Hlx1.", "locus": { "end_pos": 102637769, "start_pos": 102643223, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000002309", "id": "ENSRNOG00000002309", "database": "Ensembl Gene" } ] } } ] }