{ "uniprot_canonical_ac": "A0JPL0-1", "sequence": { "header": "sp|A0JPL0-1|ZN382_RAT Isoform 1 of Zinc finger protein 382 OS=Rattus norvegicus OX=10116 GN=Znf382 PE=1 SV=1 CANONICAL=A0JPL0-1", "length": 549, "sequence": "MNCHSVPLQGPVSFKDVTVDFTQEEWQRLDPAQKALYRDVMLENYCHFISVGFHITKPDMIRKLEQGEELWTERMFPSQSYLEDEEVLVKFRDYQDKPPTSIVIINHKKLIKERNNVYEKTLGNNHIISKTLFEYKSDGKVLKNISDFISRDINPVMGTLGDSSEWEESVLTSEQEKTHPVPTLYKQIGRNLSSSLELAQHQKTQIPEQRFECDECDSSFLMTEVAFPHDRAHRGVRDFNCSKDEIAFFEKSDLGIHPHNLMEKKCSTYNKYGKLLCRKSVFVMHPRSQVDERPFQCPYCGNSFRRKSYLIEHQRIHTGEKPYICSQCGKAFRQKTALTLHEKTHTDGKPYLCVDCGKSFRQKATLTRHHKTHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCAECGKAFIQKTTLTVHQRTHTGEKPYMCSECGKSFCQKTTLTLHQRIHTGEKPYVCSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECHECGKFFSCKSNLVAHQKTHKAETVRFQ" }, "uniprot_id": "ZN382_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "zinc finger protein 382", "multiple zinc finger and krueppel-associated box protein KS1; KRAB/zinc finger suppressor protein 1 (KS1)" ], "uniprotkb": [ "Zinc finger protein 382", "zinc finger suppressor protein 1", "KS1", "Multiple zinc finger and krueppel-associated box protein KS1" ] }, "gene": { "refseq": [ "Zfp382", "Ks1", "Znf382" ], "uniprotkb": [ "Znf382", "Zfp382", "Ks1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Zinc finger protein 382; zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1." }, "publication": [ { "title": "Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11154279", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653350.1", "id": "NP_653350.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0JPL0/publications", "id": "A0JPL0", "database": "UniProtKB" } ], "authors": "Gebelein B, Urrutia R", "date": "2001", "pmid": "11154279" }, { "title": "KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9835615", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653350.1", "id": "NP_653350.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0JPL0/publications", "id": "A0JPL0", "database": "UniProtKB" } ], "authors": "Gebelein B, Fernandez-Zapico M, Imoto M, Urrutia R", "date": "1998", "pmid": "9835615" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0#A0JPL0-1", "isoform_ac": "A0JPL0-1", "locus": { "end_pos": 88586284, "start_pos": 88592012, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087931", "id": "ENSRNOT00000087931", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069192", "id": "ENSRNOP00000069192", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0JPL0-1|ZN382_RAT Isoform 1 of Zinc finger protein 382 OS=Rattus norvegicus OX=10116 GN=Znf382 PE=1 SV=1 CANONICAL=A0JPL0-1", "length": 549, "sequence": "MNCHSVPLQGPVSFKDVTVDFTQEEWQRLDPAQKALYRDVMLENYCHFISVGFHITKPDMIRKLEQGEELWTERMFPSQSYLEDEEVLVKFRDYQDKPPTSIVIINHKKLIKERNNVYEKTLGNNHIISKTLFEYKSDGKVLKNISDFISRDINPVMGTLGDSSEWEESVLTSEQEKTHPVPTLYKQIGRNLSSSLELAQHQKTQIPEQRFECDECDSSFLMTEVAFPHDRAHRGVRDFNCSKDEIAFFEKSDLGIHPHNLMEKKCSTYNKYGKLLCRKSVFVMHPRSQVDERPFQCPYCGNSFRRKSYLIEHQRIHTGEKPYICSQCGKAFRQKTALTLHEKTHTDGKPYLCVDCGKSFRQKATLTRHHKTHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCAECGKAFIQKTTLTVHQRTHTGEKPYMCSECGKSFCQKTTLTLHQRIHTGEKPYVCSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECHECGKFFSCKSNLVAHQKTHKAETVRFQ" } }, { "url": "https://www.uniprot.org/uniprot/A0JPL0#A0A0G2JSS4-1", "isoform_ac": "A0A0G2JSS4-1", "locus": { "end_pos": 88586284, "start_pos": 88602821, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000028187", "id": "ENSRNOT00000028187", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000028187", "id": "ENSRNOP00000028187", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JSS4-1|ZN382_RAT Computationally mapped isoform of Zinc finger protein 382 OS=Rattus norvegicus OX=10116 GN=Znf382 PE=1 SV=1 CANONICAL=A0JPL0-1", "length": 566, "sequence": "MNCHSVPLQGPVSFKDVTVDFTQEEWQRLDPAQKALYRDVMLENYCHFISVGFHITKPDMIRKLEQGEELWTERMFPSQSYLEDEEVLVKFRDYQDKPPTSIVIINHKKLIKERNNVYEKTLGNNHIISKTLFEYKSDGKVLKNISDFISRDINPVMGTLGDSSEWEESVLTSEQEKTHPVPTLYKQIGRNLSSSLELAQHQKTQIPEQRFECDECDSSFLMTEVAFPHDRAHRGVRDFNCSKDEIAFFEKSDLGIHPHNLMEKKCSTYNKYGKLLCRKSVFVMHPRSQVDERPFQCPYCGNSFRRKSYLIEHQRIHTGEKPYICSQCGKAFRQKTALTLHEKTHTDGKPYLCVDCGKSFRQKATLTRHHKTHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCAECGKAFIQKTTLTVHQRTHTGEKPYMCSECGKSFCQKTTLTLHQRIHTGEKPYVCSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECHECGKFFSCKSNLVAHQKTHKAETVRFQRKMELKRAINEVEGTGR" } }, { "url": "https://www.uniprot.org/uniprot/A0JPL0#A0A0G2JYS5-1", "isoform_ac": "A0A0G2JYS5-1", "locus": { "end_pos": 88587106, "start_pos": 88602821, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000080555", "id": "ENSRNOT00000080555", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070772", "id": "ENSRNOP00000070772", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JYS5-1|ZN382_RAT Computationally mapped isoform of Zinc finger protein 382 OS=Rattus norvegicus OX=10116 GN=Znf382 PE=1 SV=1 CANONICAL=A0JPL0-1", "length": 507, "sequence": "MIRKLEQGEELWTERMFPSQSYLEDEEVLVKFRDYQDKPPTSIVIINHKKLIKERNNVYEKTLGNNHIISKTLFEYKSDGKVLKNISDFISRDINPVMGTLGDSSEWEESVLTSEQEKTHPVPTLYKQIGRNLSSSLELAQHQKTQIPEQRFECDECDSSFLMTEVAFPHDRAHRGVRDFNCSKDEIAFFEKSDLGIHPHNLMEKKCSTYNKYGKLLCRKSVFVMHPRSQVDERPFQCPYCGNSFRRKSYLIEHQRIHTGEKPYICSQCGKAFRQKTALTLHEKTHTDGKPYLCVDCGKSFRQKATLTRHHKTHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCAECGKAFIQKTTLTVHQRTHTGEKPYMCSECGKSFCQKTTLTLHQRIHTGEKPYVCSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECHECGKFFSCKSNLVAHQKTHKAETVRFQRKMELKRAINEVEGTGR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:246264", "resource": "KEGG Pathway", "id": "rno:246264", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-212436", "resource": "Reactome", "id": "R-RNO-212436", "name": "Generic Transcription Pathway" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0#function", "annotation": "Functions as a sequence-specific transcriptional repressor.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0#function", "id": "A0JPL0", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B2RXC5-1", "protein_name": "Zinc finger protein 382; zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1.", "sequence": { "length": 579, "sequence": "MGRPGRKPRGRARPGLFPFPKEELRQGGSSPANLNAMSKGPVSFKDVTVDFTQEEWQRLDPAQKALYRDVMLENYCHFISVGFHITKPDMIRKLEQGEELWTERIFPSQSYLEEEEVLVKFSDYQDKPPKSIVIIKHKKLIKERSSVYGEALGKNRVVSKTLFEYKSDGKVLKNISEFISRDINPAMGKLGGSKEWEGSILTSKQEKTHPASILHKQIGRALSSEWDLAQHQKTQIPEQRFEYNKCDSSFLMTGVEFPHGRAHRGGGNFNYSKDDITLFEKSDLGIHPHDLMEKKCSSYNKYGELLCRKSVFVMHPSSQMDERPFQCPYCGNSFRRKSYLIEHERIHTGEKPYICCQCGRAFRQKTALTLHEKTHTEGKPYLCVDCGKSFRQKATLTRHHKAHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCTECGKAFIQKTTLTVHQRTHTGEKPYICSECGKSFCQKTTLTLHQRIHTGEKPYICSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKIHTGEKPYECQECGKFFSCKSNLITHQKTHKTETMRFQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32798", "id": "32798", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96SR6-1", "protein_name": "Zinc finger protein 382; zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1.", "sequence": { "length": 550, "sequence": "MPLQGSVSFKDVTVDFTQEEWQQLDPAQKALYRDVMLENYCHFVSVGFHMAKPDMIRKLEQGEELWTQRIFPSYSYLEEDGKTEDVLVKFKEYQDRHSRPLIFINHKKLIKERSNIYGKTFTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIKEKFGDSTGWEKSLLNTKHEKIHPAVNLHKQTERVLSGKQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGERTFEYNKDGIAFIEKSSLSVHPSNLMEKKPSAYNKYGKFLCRKPVFIMPQRPQTEEKPFHCPYCGNNFRRKSYLIEHQRIHTGEKPYVCNQCGKAFRQKTALTLHEKTHIEGKPFICIDCGKSFRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKAFIQKTTLTVHQRTHTGEKPYICNECGKSFCQKTTLTLHQRIHTGEKPYICNECGKSFRQKAILTVHHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECKQCGKFFSCKSNLIVHQKTHKVETTGIQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32798", "id": "32798", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653350.1", "ac": "NP_653350.1", "name": "zinc finger protein 382; multiple zinc finger and krueppel-associated box protein KS1; KRAB/zinc finger suppressor protein 1 (KS1).", "summary": "inhibits Ha-ras, Galpha12, and Galpha13 induced transformation [RGD, Feb 2006]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001558", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "id": "A0JPL0", "database": "UniProtKB" } ], "name": "regulation of cell growth", "id": "GO:0001558" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 146, "annotation": "n_glycosylation_sequon", "start_pos": 144 }, { "end_pos": 193, "annotation": "n_glycosylation_sequon", "start_pos": 191 }, { "end_pos": 242, "annotation": "n_glycosylation_sequon", "start_pos": 240 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653350.1", "id": "NP_653350.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-212436", "id": "R-RNO-212436", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:246264", "id": "rno:246264", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020777", "id": "ENSRNOG00000020777", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "id": "cd07765", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "id": "IPR001909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "id": "IPR036051", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01352", "id": "PF01352", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPL0", "id": "PR_A0JPL0", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/246264", "id": "246264", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=708385", "id": "708385", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0JPL0", "disease": [], "mass": { "monoisotopic_mass": 63563.0, "chemical_mass": 63563.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPL0", "name": "Znf382; Zfp382; Ks1.", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "0", "evidence": [] } } ] }