{
    "uniprot_canonical_ac": "A0JPJ0-1", 
    "sequence": {
        "header": "tr|A0JPJ0-1|A0JPJ0_RAT Isoform 1 of Nicotinamide-nucleotide adenylyltransferase  OS=Rattus norvegicus OX=10116 GN=Nmnat1 PE=1 SV=1 CANONICAL=A0JPJ0-1", 
        "length": 285, 
        "sequence": "MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYLNATGEYKVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRHHQEKLATGSRSHPQSSPVLERPGRKRKWADQKQDSSPQKPQEPKPTGVPRVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICVTRAGSDAQKFIYESDVLWRHQSNIHLVTEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEEHDLYNSESEDRNAGVTLAPLQRNTSEAKHNHSTR"
    }, 
    "uniprot_id": "A0JPJ0_RAT", 
    "enzyme_annotation": [
        {
            "ec": "2.7.7.1", 
            "activity": "ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)."
        }, 
        {
            "ec": "2.7.7.18", 
            "activity": "ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)."
        }, 
        {
            "ec": "2.7.7.18", 
            "activity": ""
        }, 
        {
            "ec": "2.7.7.1", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1", 
                "nicotinamide mononucleotide adenylyl transferase 1"
            ], 
            "uniprotkb": [
                "Nicotinamide-nucleotide adenylyltransferase", 
                "2.7.7.1", 
                "2.7.7.18", 
                "Nicotinate-nucleotide adenylyltransferase"
            ]
        }, 
        "gene": {
            "refseq": [
                "Nmnat1"
            ], 
            "uniprotkb": [
                "Nmnat1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                    "id": "A0JPJ0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Nicotinamide-nucleotide adenylyltransferase; 2.7.7.1; 2.7.7.18; Nicotinate-nucleotide adenylyltransferase."
    }, 
    "publication": [
        {
            "title": "Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in Response to High Glucose Stress.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/27184051", 
            "journal": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhou RM, Shen Y, Yao J, Yang H, Shan K, Li XM, Jiang Q, Yan B", 
            "date": "2016", 
            "pmid": "27184051"
        }, 
        {
            "title": "ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/27257257", 
            "journal": "Science (New York, N.Y.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA, Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B, Beato M", 
            "date": "2016", 
            "pmid": "27257257"
        }, 
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPJ0/publications", 
                    "id": "A0JPJ0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012", 
            "pmid": "22673903"
        }, 
        {
            "title": "Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22365601", 
            "journal": "Chemistry & biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Cohen MS, Ghosh AK, Kim HJ, Jeon NL, Jaffrey SR", 
            "date": "2012", 
            "pmid": "22365601"
        }, 
        {
            "title": "Proteomic characterization of the human sperm nucleus.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21630459", 
            "journal": "Proteomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "de Mateo S, Castillo J, Estanyol JM, Ballesca JL, Oliva R", 
            "date": "2011", 
            "pmid": "21630459"
        }, 
        {
            "title": "Next-generation sequencing to generate interactome datasets.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21516116", 
            "journal": "Nature methods", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M", 
            "date": "2011", 
            "pmid": "21516116"
        }, 
        {
            "title": "Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16118205", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Berger F, Lau C, Dahlmann M, Ziegler M", 
            "date": "2005", 
            "pmid": "16118205"
        }, 
        {
            "title": "The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15381699", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Revollo JR, Grimm AA, Imai S", 
            "date": "2004", 
            "pmid": "15381699"
        }, 
        {
            "title": "Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11027696", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Emanuelli M, Carnevali F, Saccucci F, Pierella F, Amici A, Raffaelli N, Magni G", 
            "date": "2001", 
            "pmid": "11027696"
        }, 
        {
            "title": "Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11248244", 
            "journal": "FEBS letters", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Schweiger M, Hennig K, Lerner F, Niere M, Hirsch-Kauffmann M, Specht T, Weise C, Oei SL, Ziegler M", 
            "date": "2001", 
            "pmid": "11248244"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPJ0#A0JPJ0-1", 
            "isoform_ac": "A0JPJ0-1", 
            "locus": {
                "end_pos": 166410613, 
                "start_pos": 166419421, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000048914", 
                        "id": "ENSRNOT00000048914", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000041982", 
                        "id": "ENSRNOP00000041982", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0JPJ0-1|A0JPJ0_RAT Isoform 1 of Nicotinamide-nucleotide adenylyltransferase  OS=Rattus norvegicus OX=10116 GN=Nmnat1 PE=1 SV=1 CANONICAL=A0JPJ0-1", 
                "length": 285, 
                "sequence": "MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYLNATGEYKVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRHHQEKLATGSRSHPQSSPVLERPGRKRKWADQKQDSSPQKPQEPKPTGVPRVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICVTRAGSDAQKFIYESDVLWRHQSNIHLVTEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEEHDLYNSESEDRNAGVTLAPLQRNTSEAKHNHSTR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:298653", 
            "resource": "KEGG Pathway", 
            "id": "rno:298653", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-196807", 
            "resource": "Reactome", 
            "id": "R-RNO-196807", 
            "name": "Nicotinate metabolism"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
            "annotation": "Nmnat1 protects Retinal Ganglion Cells against high glucose-induced injury via p38-MAPK signaling pathway.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
            "annotation": "The axonal pool of Wld(S) is necessary for protection from axon degeneration.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
                    "id": "NP_001032645.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9HAN9-1", 
            "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; 2.7.7.1; 2.7.7.18; Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1.", 
            "sequence": {
                "length": 279, 
                "sequence": "MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTLERPGRKRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLYSSESEDRNAGVILAPLQRNTAEAKT"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/39074", 
                    "id": "39074", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q9EPA7-1", 
            "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; 2.7.7.1; 2.7.7.18; Nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1.", 
            "sequence": {
                "length": 285, 
                "sequence": "MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/39074", 
                    "id": "39074", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0JPJ0/", 
                    "id": "A0JPJ0", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
        "ac": "NP_001032645.2", 
        "name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; nicotinamide mononucleotide adenylyl transferase 1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004515", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nicotinate-nucleotide adenylyltransferase activity", 
                        "id": "GO:0004515"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000309", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nicotinamide-nucleotide adenylyltransferase activity", 
                        "id": "GO:0000309"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear body", 
                        "id": "GO:0016604"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of MAPK cascade", 
                        "id": "GO:0043410"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of neuron apoptotic process", 
                        "id": "GO:0043524"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009435", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "NAD biosynthetic process", 
                        "id": "GO:0009435"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902511", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of apoptotic DNA fragmentation", 
                        "id": "GO:1902511"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to wounding", 
                        "id": "GO:0009611"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990966", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
                                "id": "A0JPJ0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP generation from poly-ADP-D-ribose", 
                        "id": "GO:1990966"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 38, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 36
        }, 
        {
            "end_pos": 276, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 274
        }, 
        {
            "end_pos": 283, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 281
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032645.2", 
            "id": "NP_001032645.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-196807", 
            "id": "R-RNO-196807", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:298653", 
            "id": "rno:298653", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015962", 
            "id": "ENSRNOG00000015962", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PAHHRVI/", 
            "id": "PAHHRVI", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005248", 
            "id": "IPR005248", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004821", 
            "id": "IPR004821", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01467", 
            "id": "PF01467", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/298653", 
            "id": "298653", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310996", 
            "id": "1310996", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0JPJ0", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 32534.0, 
        "chemical_mass": 32534.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPJ0", 
            "name": "Nmnat1.", 
            "locus": {
                "end_pos": 166409461, 
                "start_pos": 166430254, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000015962", 
                        "id": "ENSRNOG00000015962", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}