{ "uniprot_canonical_ac": "A0JNU3-1", "sequence": { "header": "sp|A0JNU3-1|LPP60_MOUSE Isoform 1 of 60 kDa lysophospholipase OS=Mus musculus OX=10090 GN=Aspg PE=1 SV=1 CANONICAL=A0JNU3-1", "length": 564, "sequence": "MARAMGPERRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLKTLHMFHDEEYAQAHSLPEDTLVLPPASPDQRIIYTVLECQPLFDSSDMTITEWVQIAQTIERHYAQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVVLTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKACGKSHLVVHSSMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLLQELRVAAEQGLIIVNCTHCLQGAVTSDYASGMAMAGAGIVSGFDMTSEAALAKLSYVLGQPGLSLNDRKKLLAKDLRGEMTLPATDVLLQDGMLGCRVAWLLSMNGSQEADTMKDVLLPGLALAAAHAGDLDTLQAFVELDRDLNLKDYSGQTPLHVAARRGHAAVVTMLLQRGADVDARNEDGQSPLLLAVRGRHQSVIGLLRAAGARLSPQELEDVGTELCRLASRGDSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSFKDSVCAQPQPH" }, "uniprot_id": "LPP60_MOUSE", "enzyme_annotation": [ { "ec": "3.5.1.1", "activity": "L-asparagine + H(2)O = L-aspartate + NH(3)." }, { "ec": "3.1.1.47", "activity": "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." }, { "ec": "3.1.1.5", "activity": "2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate." }, { "ec": "3.1.1.5", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "60 kDa lysophospholipase", "60 kDa lysophospholipase [Includes: L-asparaginase; asparaginase homolog; lysophospholipase-transacylase" ], "uniprotkb": [ "60 kDa lysophospholipase", "3.1.1.5", "Lysophospholipase-transacylase", "L-asparagine amidohydrolase", "Platelet-activating factor acetylhydrolase", "PAF acetylhydrolase" ] }, "gene": { "refseq": [ "Aspg", "A530050D06Rik", "AI429460", "Gm690" ], "uniprotkb": [ "Aspg", "A530050D06Rik", "AI429460", "Gm690" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "60 kDa lysophospholipase; 3.1.1.5; Lysophospholipase-transacylase; L-asparagine amidohydrolase; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3#A0JNU3-1", "isoform_ac": "A0JNU3-1", "locus": { "end_pos": 112106892, "start_pos": 112126742, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000079400", "id": "ENSMUST00000079400", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000078369", "id": "ENSMUSP00000078369", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0JNU3-1|LPP60_MOUSE Isoform 1 of 60 kDa lysophospholipase OS=Mus musculus OX=10090 GN=Aspg PE=1 SV=1 CANONICAL=A0JNU3-1", "length": 564, "sequence": "MARAMGPERRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLKTLHMFHDEEYAQAHSLPEDTLVLPPASPDQRIIYTVLECQPLFDSSDMTITEWVQIAQTIERHYAQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVVLTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKACGKSHLVVHSSMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLLQELRVAAEQGLIIVNCTHCLQGAVTSDYASGMAMAGAGIVSGFDMTSEAALAKLSYVLGQPGLSLNDRKKLLAKDLRGEMTLPATDVLLQDGMLGCRVAWLLSMNGSQEADTMKDVLLPGLALAAAHAGDLDTLQAFVELDRDLNLKDYSGQTPLHVAARRGHAAVVTMLLQRGADVDARNEDGQSPLLLAVRGRHQSVIGLLRAAGARLSPQELEDVGTELCRLASRGDSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSFKDSVCAQPQPH" } }, { "url": "https://www.uniprot.org/uniprot/A0JNU3#A0A1Y7VLT0-1", "isoform_ac": "A0A1Y7VLT0-1", "locus": { "end_pos": 112106911, "start_pos": 112114063, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000220719", "id": "ENSMUST00000220719", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152630", "id": "ENSMUSP00000152630", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VLT0-1|LPP60_MOUSE Computationally mapped isoform of 60 kDa lysophospholipase OS=Mus musculus OX=10090 GN=Aspg PE=1 SV=1 CANONICAL=A0JNU3-1", "length": 68, "sequence": "XERRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLKTLHMFHDEEYAQAHSLPEDTLVLPHTSGQHATRK" } }, { "url": "https://www.uniprot.org/uniprot/A0JNU3#A0A1Y7VK88-1", "isoform_ac": "A0A1Y7VK88-1", "locus": { "end_pos": 112121152, "start_pos": 112126367, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000222970", "id": "ENSMUST00000222970", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152762", "id": "ENSMUSP00000152762", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VK88-1|LPP60_MOUSE Computationally mapped isoform of 60 kDa lysophospholipase OS=Mus musculus OX=10090 GN=Aspg PE=1 SV=1 CANONICAL=A0JNU3-1", "length": 156, "sequence": "XAMAGAGIVSGFDMTSEAALAKLSYVLGQPGLSLNDRKKLLAKDLRGEMTLPATDVLLQDGMLGCRVAWLLSMNGSQEADTMKDVLLPGLALAAAHAGDLDTLQAFVELASECHWAAESCWGPPVSPGAGGRWDRAVQAGIKGRQRRPAGMVAGWG" } }, { "url": "https://www.uniprot.org/uniprot/A0JNU3#A0A1Y7VK61-1", "isoform_ac": "A0A1Y7VK61-1", "locus": { "end_pos": 112112940, "start_pos": 112116500, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000223184", "id": "ENSMUST00000223184", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152728", "id": "ENSMUSP00000152728", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VK61-1|LPP60_MOUSE Computationally mapped isoform of 60 kDa lysophospholipase OS=Mus musculus OX=10090 GN=Aspg PE=1 SV=1 CANONICAL=A0JNU3-1", "length": 103, "sequence": "RRKAEWETGSASCSPASPDQRIIYTVLECQPLFDSSDMTITEYLSTHCGVTAVRTCWGLCSWLANTSSLRSACSSRISSSGAIGQPRWTLGGLPPSAPLTCPL" } }, { "url": "https://www.uniprot.org/uniprot/A0JNU3#A0A1Y7VIV3-1", "isoform_ac": "A0A1Y7VIV3-1", "locus": { "end_pos": 112106869, "start_pos": 112116527, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000223412", "id": "ENSMUST00000223412", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152155", "id": "ENSMUSP00000152155", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VIV3-1|LPP60_MOUSE Computationally mapped isoform of 60 kDa lysophospholipase OS=Mus musculus OX=10090 GN=Aspg PE=1 SV=1 CANONICAL=A0JNU3-1", "length": 179, "sequence": "XEEPAVSAMARAMGPERRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLKTLHMFHDEEYAQAHSLPEDTLVLPPASPDQRIIYTVLECQPLFDSSDMTITEWVQIAQTIEVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:104816", "resource": "KEGG Pathway", "id": "mmu:104816", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8963693", "resource": "Reactome", "id": "R-MMU-8963693", "name": "Aspartate and asparagine metabolism" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3#function", "annotation": "Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3#function", "id": "A0JNU3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q86U10-1", "protein_name": "60 kDa lysophospholipase; LysoLP; 3.1.1.5; L-asparagine amidohydrolase; Lysophospholipase-transacylase; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase.", "sequence": { "length": 573, "sequence": "MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDTLVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMAFAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGLLRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCLQGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEVLPGV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0JNU3/", "id": "A0JNU3", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/113390", "id": "113390", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "O88202-1", "protein_name": "60 kDa lysophospholipase; 3.1.1.5; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; Lysophospholipase-transacylase; L-asparagine amidohydrolase.", "sequence": { "length": 564, "sequence": "MARATGPEQRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLRTLHMLHDEEYARAHSLPEDTLVLPPASSDQRIIYKVLECQPLFDSSDMTITEWVQIAQTIERHYTQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVILTGAQVPIHELWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKASWKSHLVVHSNMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLIQELRAAAERGLIIVNCTHCLQGAVTSDYAPGMAMAGAGIISGFDMTSEAALAKLSYVLGQPGLSLSDRKKLLAKDLRGEMTLPTTDDLLGDDMLGCRATWLLSMNGSQDADAMKDVLLPGLALAAAHAGDLDTLQAFVELGRDLNLKDYSGQTPLHVAARRGHASVVAMLLQKGVDVDACNEDGQSPLLLAVRGRHQSVIRLLRAAGAHLSPQELEDVGTELCRLASRADSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSLEDRVSAQPQPH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/113390", "id": "113390", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074638.1", "ac": "NP_001074638.1", "name": "60 kDa lysophospholipase; 60 kDa lysophospholipase [Includes: L-asparaginase; asparaginase homolog; lysophospholipase-transacylase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "lysophospholipase activity", "id": "GO:0004622" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004067", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "asparaginase activity", "id": "GO:0004067" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016747", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "transferase activity, transferring acyl groups other than amino-acyl groups", "id": "GO:0016747" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003847", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "id": "GO:0003847" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006528", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "asparagine metabolic process", "id": "GO:0006528" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "lipid catabolic process", "id": "GO:0016042" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006644", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "id": "A0JNU3", "database": "UniProtKB" } ], "name": "phospholipid metabolic process", "id": "GO:0006644" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 186, "annotation": "n_glycosylation_sequon", "start_pos": 184 }, { "end_pos": 297, "annotation": "n_glycosylation_sequon", "start_pos": 295 }, { "end_pos": 387, "annotation": "n_glycosylation_sequon", "start_pos": 385 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074638.1", "id": "NP_001074638.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8963693", "id": "R-MMU-8963693", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:104816", "id": "mmu:104816", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037686", "id": "ENSMUSG00000037686", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/QYGADLC/", "id": "QYGADLC", "database": "OMA" }, { "url": "N/A", "id": "3.1.1.47", "database": "BRENDA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08963", "id": "cd08963", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "id": "IPR002110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", "id": "IPR020683", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "id": "IPR036770", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006033", "id": "IPR006033", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027473", "id": "IPR027473", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006034", "id": "IPR006034", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027474", "id": "IPR027474", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027475", "id": "IPR027475", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036152", "id": "IPR036152", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037152", "id": "IPR037152", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040919", "id": "IPR040919", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041725", "id": "IPR041725", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00710", "id": "PF00710", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17763", "id": "PF17763", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JNU3", "id": "PR_A0JNU3", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/104816", "id": "104816", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2144822", "id": "2144822", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A0JNU3", "disease": [], "mass": { "monoisotopic_mass": 60595.0, "chemical_mass": 60595.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JNU3", "name": "Aspg; A530050D06Rik; AI429460; Gm690.", "locus": { "end_pos": 112127559, "start_pos": 112106679, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000037686", "id": "ENSMUSG00000037686", "database": "Ensembl Gene" } ] } } ] }