{ "uniprot_canonical_ac": "A0A5B9-1", "sequence": { "header": "sp|A0A5B9-1|TRBC2_HUMAN Isoform 1 of T cell receptor beta constant 2 OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1", "length": 178, "sequence": "DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG" }, "uniprot_id": "TRBC2_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "T cell receptor beta constant 2" ] }, "gene": { "refseq": [], "uniprotkb": [ "TRBC2", "TCRBC2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9", "id": "A0A5B9", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "T cell receptor beta constant 2." }, "publication": [ { "title": "Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27183389", "journal": "J. Clin. Invest.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Rossjohn J., Zhu C., Bulek A.M., Cole D.K., Dolton G., Fuller A., Jothikumar P., Miles J.J., Peakman M., Rittase W., Rizkallah P.J., Schauenberg A.J., Sewell A.K., Skowera A., Szomolay B., Trimby A., Wooldridge L.", "date": "2016", "pmid": "27183389" }, { "title": "A 'hotspot' for autoimmune T cells in type 1 diabetes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27183386", "journal": "J. Clin. 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U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Rossjohn J., Gras S., Miller A., Clemens E.B., Doherty P.C., Grant E.J., Josephs T.M., Kedzierska K., Nguyen T.H., Price D.A., Thomas P.G., Tong S.Y., Valkenburg S.A., Wang G.C.", "date": "2016", "pmid": "27036003" }, { "title": "Two common structural motifs for TCR recognition by staphylococcal enterotoxins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27180909", "journal": "Sci. Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Baker D., Ford A., Bahl C., Lindkvist-Petersson K., Regenthal P., Rodstrom K.E.", "date": "2016", "pmid": "27180909" }, { "title": "Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26875526", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Rossjohn J., Gras S., Godfrey D.I., Pellicci D.G., Uldrich A.P., Gherardin N.A., Howell A.R., Keshipeddy S., Le Nours J., Lim R.T., Praveena T., Richardson S.K., Besra G.S., Ross F.J.", "date": "2016", "pmid": "26875526" }, { "title": "A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26917722", "journal": "J. Biol. 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Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Li M., Wang J., Zhao M., Yuan W., Wen X., Zajonc D.M., Besra G.S., Illarionov P.A., Kronenberg M., Porcelli S.A., Girardi E., Khurana A., Birkholz A.M., Wingender G., Zahner S.", "date": "2015", "pmid": "26078271" }, { "title": "T cell antigen receptor recognition of antigen-presenting molecules.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25493333", "journal": "Annu. Rev. 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Med.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Li Y., Wang J., Zajonc D.M., Kronenberg M., Girardi E., Painter G.F., Yu E.D.", "date": "2010", "pmid": "20921281" }, { "title": "Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20452950", "journal": "Cold Spring Harb. Perspect. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Gagnon E., Wucherpfennig K.W., Call M.E., Call M.J., Huseby E.S.", "date": "2010", "pmid": "20452950" }, { "title": "A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16505140", "journal": "J. Exp. Med.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A5B9/publications", "id": "A0A5B9", "database": "UniProtKB" } ], "authors": "Rossjohn J., Clements C.S., Kjer-Nielsen L., McCluskey J., Godfrey D.I., Pellicci D.G., Beddoe T., Kostenko L., Reid H.H., Besra G.S., Bharadwaj M., Borg N.A., Smyth M.J., Williamson N.A.", "date": "2006", "pmid": "16505140" }, { "title": "The many important facets of T-cell repertoire diversity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15040585", "journal": "Nat. Rev. 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Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. 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