{ "uniprot_canonical_ac": "A0A2I3BR92-1", "sequence": { "header": "tr|A0A2I3BR92-1|A0A2I3BR92_MOUSE Isoform 1 of Mcf.2-transforming sequence OS=Mus musculus OX=10090 GN=Mcf2 PE=4 SV=1 CANONICAL=A0A2I3BR92-1", "length": 1111, "sequence": "MAEAGPPPARFPPARLPPAGSSRAGLPPTGSPPASTPALASQWLAVKRLPRAAAKAPNLQLNQDHCSFVPFTQAVPVQVDMAMALHRVRIAEKYGKNYLCLLQAVFLAETGLLLQLKDINHFLMQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLNYLTSIARQSGSDSRFTIILDRRLDTWASLKISLQKISASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKHVKKSWRQIHAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVLNELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGEDRTQMRHMSEVTF" }, "uniprot_id": "A0A2I3BR92_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "proto-oncogene DBL isoform 1" ], "uniprotkb": [ "Mcf.2-transforming sequence" ] }, "gene": { "refseq": [ "Mcf2", "B230117G22Rik", "Dbl", "Mcf-2" ], "uniprotkb": [ "Mcf2", "B230117G22Rik", "Dbl", "Mcf-2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Mcf.2-transforming sequence." }, "publication": [ { "title": "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28541439", "journal": "Genome biology and evolution", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ], "authors": "Fort P, Blangy A", "date": "2017", "pmid": "28541439" }, { "title": "Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24647000", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ], "authors": "Ramasamy SK, Kusumbe AP, Wang L, Adams RH", "date": "2014", "pmid": "24647000" }, { "title": "Identification of a novel mouse Dbl proto-oncogene splice variant: evidence that SEC14 domain is involved in GEF activity regulation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24412292", "journal": "Gene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ], "authors": "Ognibene M, Vanni C, Blengio F, Segalerba D, Mancini P, De Marco P, Torrisi MR, Bosco MC, Varesio L, Eva A", "date": "2014", "pmid": "24412292" }, { "title": "Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/13679059", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ], "authors": "Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S", "date": "2003", "pmid": "13679059" }, { "title": "Oncogene ect2 is related to regulators of small GTP-binding proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8464478", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ], "authors": "Miki T, Smith CL, Long JE, Eva A, Fleming TP", "date": "1993", "pmid": "8464478" }, { "title": "Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/1572654", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ], "authors": "Faust CJ, Verkerk AJ, Wilson PJ, Morris CP, Hopwood JJ, Oostra BA, Herman GE", "date": "1992", "pmid": "1572654" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92#Q8C067-1", "isoform_ac": "Q8C067-1", "locus": { "end_pos": 60056667, "start_pos": 60147524, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000101531", "id": "ENSMUST00000101531", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000099070", "id": "ENSMUSP00000099070", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8C067-1|A0A2I3BR92_MOUSE Computationally mapped isoform of Mcf.2-transforming sequence OS=Mus musculus OX=10090 GN=Mcf2 PE=4 SV=1 CANONICAL=A0A2I3BR92-1", "length": 928, "sequence": "MAEANPPRGKMRFRRNAASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKHVKKSWRQIHAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVLNELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGEDRTQMRHMSEVTF" } }, { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92#A0A2I3BR92-1", "isoform_ac": "A0A2I3BR92-1", "locus": { "end_pos": 60056667, "start_pos": 60178906, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000228150", "id": "ENSMUST00000228150", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000154494", "id": "ENSMUSP00000154494", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A2I3BR92-1|A0A2I3BR92_MOUSE Isoform 1 of Mcf.2-transforming sequence OS=Mus musculus OX=10090 GN=Mcf2 PE=4 SV=1 CANONICAL=A0A2I3BR92-1", "length": 1111, "sequence": "MAEAGPPPARFPPARLPPAGSSRAGLPPTGSPPASTPALASQWLAVKRLPRAAAKAPNLQLNQDHCSFVPFTQAVPVQVDMAMALHRVRIAEKYGKNYLCLLQAVFLAETGLLLQLKDINHFLMQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLNYLTSIARQSGSDSRFTIILDRRLDTWASLKISLQKISASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKHVKKSWRQIHAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVLNELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGEDRTQMRHMSEVTF" } }, { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92#A2AET8-1", "isoform_ac": "A2AET8-1", "locus": { "end_pos": 60056667, "start_pos": 60147524, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000033478", "id": "ENSMUST00000033478", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000033478", "id": "ENSMUSP00000033478", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AET8-1|A0A2I3BR92_MOUSE Computationally mapped isoform of Mcf.2-transforming sequence OS=Mus musculus OX=10090 GN=Mcf2 PE=4 SV=1 CANONICAL=A0A2I3BR92-1", "length": 944, "sequence": "MAEANPPRGKMRFRRNAASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKHVGIGYSFFQACRIFLKVKKSWRQIHAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVLNELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGEDRTQMRHMSEVTF" } }, { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92#Q8BLE2-1", "isoform_ac": "Q8BLE2-1", "locus": { "end_pos": 60056667, "start_pos": 60178666, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000063507", "id": "ENSMUST00000063507", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000067075", "id": "ENSMUSP00000067075", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8BLE2-1|A0A2I3BR92_MOUSE Computationally mapped isoform of Mcf.2-transforming sequence OS=Mus musculus OX=10090 GN=Mcf2 PE=4 SV=1 CANONICAL=A0A2I3BR92-1", "length": 1031, "sequence": "MAMALHRVRIAEKYGKNYLCLLQAVFLAETGLLLQLKDINHFLMQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLNYLTSIARQSGSDSRFTIILDRRLDTWASLKISLQKISASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKHVKKSWRQIHAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVLNELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGEDRTQMRHMSEVTF" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-194840", "resource": "Reactome", "id": "R-MMU-194840", "name": "Rho GTPase cycle" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193648", "resource": "Reactome", "id": "R-MMU-193648", "name": "NRAGE signals death through JNK" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "resource": "Reactome", "id": "R-MMU-416482", "name": "G alpha (12/13) signalling events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193634", "resource": "Reactome", "id": "R-MMU-193634", "name": "Axonal growth inhibition (RHOA activation)" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "annotation": "Msf2 variant molecule containing an altered SEC14 protein module displays enhanced translocation to the plasma membrane and cell transforming potential.Msf2 expression of this variant in mouse brain suggests that it can be implicated in brain development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "annotation": "Provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P10911-1", "protein_name": "Proto-oncogene DBL; Proto-oncogene MCF-2.", "sequence": { "length": 925, "sequence": "MAEANPRRGKMRFRRNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3917", "id": "3917", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "ac": "NP_001276660.1", "name": "proto-oncogene DBL isoform 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005089", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "Rho guanyl-nucleotide exchange factor activity", "id": "GO:0005089" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016358", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "dendrite development", "id": "GO:0016358" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990830", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "cellular response to leukemia inhibitory factor", "id": "GO:1990830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "id": "A0A2I3BR92", "database": "UniProtKB" } ], "name": "regulation of Rho protein signal transduction", "id": "GO:0035023" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 857, "annotation": "n_glycosylation_sequon", "start_pos": 855 }, { "end_pos": 1038, "annotation": "n_glycosylation_sequon", "start_pos": 1036 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276660.1", "id": "NP_001276660.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-194840", "id": "R-MMU-194840", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193648", "id": "R-MMU-193648", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "id": "R-MMU-416482", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193634", "id": "R-MMU-193634", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "id": "cd00160", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "id": "cd00170", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "id": "IPR000219", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", "id": "IPR001331", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "id": "IPR035899", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "id": "IPR001251", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00169", "id": "PF00169", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00621", "id": "PF00621", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13716", "id": "PF13716", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/109904", "id": "109904", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:96932", "id": "96932", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A0A2I3BR92", "disease": [], "mass": { "monoisotopic_mass": 127170.0, "chemical_mass": 127170.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A2I3BR92", "name": "Mcf2; B230117G22Rik; Dbl; Mcf-2.", "locus": { "end_pos": 60055956, "start_pos": 60179089, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000031139", "id": "ENSMUSG00000031139", "database": "Ensembl Gene" } ] } } ] }