{ "uniprot_canonical_ac": "A0A1W2Q693-1", "sequence": { "header": "tr|A0A1W2Q693-1|A0A1W2Q693_RAT Isoform 1 of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1", "length": 862, "sequence": "MACGATERGPEPPAFQRHPEASAPRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRVLTHFHTTPEDYSVIFTAGSTAALRLVAETFPWVSRSPENSGSHFCYLTDNHTSVVGMRTVAATMNVTSTPVKPEDMWSAEGKGAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWIDEVKSGQRSPVRAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKRVAPLLRKGYFGGGTAAVYLAGEDFYIPRSSVAERFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDVQGPIINFNVLDDAGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSEEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPGGQPVPQASTSDTGVLSSKSDCQSPQEGPCADPAVSSGSYPDINTVDLDLSQSKASSIQPIPQEKVAGILNGDLGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPCIDLQQKVMVIKAEGMEPIQVPLEEDGERTQICQSRVCADRVNTYDCGENVSRWLSKFCGRPCHLIKQSPHFQRNAKKTPKQGHPPGTAVALSLVNEAQYLLVNTSSVLELQQQLNASDERGKEESFSVKDLISRFRANIITKGARAFEEEQWDEISIGSLHFQVLGPCHRCQMICIDQKTGQRNQDVFQKLSESRGRKVNFGVYLMHSSLDLSSPCFLSVGSEVLPVLKDCGVS" }, "uniprot_id": "A0A1W2Q693_RAT", "enzyme_annotation": [ { "ec": "2.8.1.9", "activity": "Molybdenum cofactor + L-cysteine + reduced acceptor + 2 H(+) = thio-molybdenum cofactor + L-alanine + H(2)O + oxidized acceptor." }, { "ec": "2.8.1.9", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "molybdenum cofactor sulfurase isoform X1" ], "uniprotkb": [ "Molybdenum cofactor sulfurase", "MOS", "2.8.1.9", "MCS", "MoCo sulfurase", "Molybdenum cofactor sulfurtransferase" ] }, "gene": { "refseq": [ "Mocos" ], "uniprotkb": [ "Mocos", "MOCOS" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Molybdenum cofactor sulfurase; MOS; 2.8.1.9; MCS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase.", "short": "MOS" }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#A0A1W2Q677-1", "isoform_ac": "A0A1W2Q677-1", "locus": { "end_pos": 16616937, "start_pos": 16635898, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000093641", "id": "ENSRNOT00000093641", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000076169", "id": "ENSRNOP00000076169", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2Q677-1|A0A1W2Q693_RAT Computationally mapped isoform of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1", "length": 124, "sequence": "XCLIQPCIDLQQKVMVIKAEGMEPIQVPLEEDGERTQICQSRVCADRVNTYDCGENVSRWLSKFCGRPCHLIKQSPHFQRNAKKTPKQGHPPGTAVALSLVNEAQYLLVNTSSVLELQQQLNAR" } }, { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#A0A1W2Q693-1", "isoform_ac": "A0A1W2Q693-1", "locus": { "end_pos": 16590638, "start_pos": 16636004, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000093715", "id": "ENSRNOT00000093715", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000076171", "id": "ENSRNOP00000076171", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2Q693-1|A0A1W2Q693_RAT Isoform 1 of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1", "length": 862, "sequence": "MACGATERGPEPPAFQRHPEASAPRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRVLTHFHTTPEDYSVIFTAGSTAALRLVAETFPWVSRSPENSGSHFCYLTDNHTSVVGMRTVAATMNVTSTPVKPEDMWSAEGKGAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWIDEVKSGQRSPVRAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKRVAPLLRKGYFGGGTAAVYLAGEDFYIPRSSVAERFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDVQGPIINFNVLDDAGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSEEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPGGQPVPQASTSDTGVLSSKSDCQSPQEGPCADPAVSSGSYPDINTVDLDLSQSKASSIQPIPQEKVAGILNGDLGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPCIDLQQKVMVIKAEGMEPIQVPLEEDGERTQICQSRVCADRVNTYDCGENVSRWLSKFCGRPCHLIKQSPHFQRNAKKTPKQGHPPGTAVALSLVNEAQYLLVNTSSVLELQQQLNASDERGKEESFSVKDLISRFRANIITKGARAFEEEQWDEISIGSLHFQVLGPCHRCQMICIDQKTGQRNQDVFQKLSESRGRKVNFGVYLMHSSLDLSSPCFLSVGSEVLPVLKDCGVS" } }, { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#A0A1W2Q6E8-1", "isoform_ac": "A0A1W2Q6E8-1", "locus": { "end_pos": 16590638, "start_pos": 16609554, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000093441", "id": "ENSRNOT00000093441", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000076247", "id": "ENSRNOP00000076247", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2Q6E8-1|A0A1W2Q693_RAT Computationally mapped isoform of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1", "length": 171, "sequence": "MACGATERGPEPPAFQRHPEASAPRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDV" } }, { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#D4A1G3-1", "isoform_ac": "D4A1G3-1", "locus": { "end_pos": 16603367, "start_pos": 16636004, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066583", "id": "ENSRNOT00000066583", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000061024", "id": "ENSRNOP00000061024", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A1G3-1|A0A1W2Q693_RAT Computationally mapped isoform of Molybdenum cofactor sulfurase OS=Rattus norvegicus OX=10116 GN=Mocos PE=1 SV=1 CANONICAL=A0A1W2Q693-1", "length": 698, "sequence": "MNVTSTPVKPEDMWSAEGKGAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWIDEVKSGQRSPVRAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKRVAPLLRKGYFGGGTAAVYLAGEDFYIPRSSVAERFEDGTISFLDVIALKHGFDVLERLTGGMVNIQQHTFALLHFTHSALSSLRYPNGAPVVRIYGDSGFSSPDVQGPIINFNVLDDAGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSEEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPGGQPVPQASTSDTGVLSSKSDCQSPQEGPCADPAVSSGSYPDINTVDLDLSQSKASSIQPIPQEKVAGILNGDLGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPCIDLQQKVMVIKAEGMEPIQVPLEEDGERTQICQSRVCADRVNTYDCGENVSRWLSKFCGRPCHLIKQSPHFQRNAKKTPKQGHPPGTAVALSLVNEAQYLLVNTSSVLELQQQLNASDERGKEESFSVKDLISRFRANIITKGARAFEEEQWDEISIGSLHFQVLGPCHRCQMICIDQKTGQRNQDVFQKLSESRGRKVNFGVYLMHSSLDLSSPCFLSVGSEVLPVLKDCGVS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-947581", "resource": "Reactome", "id": "R-RNO-947581", "name": "Molybdenum cofactor biosynthesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#function", "annotation": "Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693#function", "id": "A0A1W2Q693", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q14CH1-1", "protein_name": "Molybdenum cofactor sulfurase; MOS; 2.8.1.9; MCS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase.", "sequence": { "length": 862, "sequence": "MACGAAERGPEPPAFQRHLEASTQRLAHGYGLRSMSELRDQEFGRLAGTVYLDHAGATLFPQSQLTNFTKDLMENVYGNPHSQNITSKLTHDTVEQVRYRILTHFHTTPEDYIVIFTAGSTAALRLVAEAFPWVSRSPENSGSHFCYLTDNHTSVVGMRKVAAAMSVTSIPVKPEDMWSAEGKDAGACDPDCQLPHLFCYPAQSNFSGTRYPLSWVEEVKSGRRSPVNAPGKWFVLLDAASYVSTSPLDLSAHQADFIPISFYKIFGLPTGLGALLVNKHVAPLLRKGYFGGGTAAAYLAGEDFYVPRSSVAERFEDGTISFLDVIALKHGFDALEHLTGGMVNIQQHTFALVQYTHSALSSLRYLNGAPVVRIYSDSEFSSPDVQGPIINFNVLDDGGKIIGYSQVDKMASLYNIHLRTGCFCNLGACQRHLGLSDEMVKKHFQAGHVCGDDVDIIDGRPTGSVRISFGYMSTLEDAQAFLRFISTIYLRSPSDQPVPQASISDAGALTSKSDCHSPQEGSCTDPSVCNGSYPDTNIMDLHPSLSKASSAQQTPQDKAAGILNGDPGSHIVTNIYLYPIKSCAAFEVTKWPVGSQGLLYDRSWMVVNHNGICMSQKQEPRLCLIQPFIDLQQRIMVIKAEGMEPIQVPLEEDGEQTQICQSRVCADRVNTYDCGENVSRWLSKFLGRLCHLIKQSPHFQRNARKTPKKGQPPGTTVALSLVNEAQYLLVNTSSILELQRQLNASDEHGKEESFSMKDLISRFRANIITKGARAFEEEKWDEISIGSLHFQVLGPCHRCQMICINQQTGQRNQDVFQTLSESRGRKVNFGVYLMHSYLDLSSPCFLSVGSEVLPVLKDCGVS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9931", "id": "9931", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96EN8-1", "protein_name": "Molybdenum cofactor sulfurase; MOS; 2.8.1.9; MCS; MoCo sulfurase; hMCS; Molybdenum cofactor sulfurtransferase.", "sequence": { "length": 888, "sequence": "MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVISTPVRPEDLWSAEERSASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEEVKSGRLHPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNRAAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTFTLAQYTYVALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9931", "id": "9931", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254528.1", "ac": "XP_006254528.1", "name": "molybdenum cofactor sulfurase isoform X1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030151", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "molybdenum ion binding", "id": "GO:0030151" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "pyridoxal phosphate binding", "id": "GO:0030170" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "lyase activity", "id": "GO:0016829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008265", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "Mo-molybdopterin cofactor sulfurase activity", "id": "GO:0008265" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102867", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "molybdenum cofactor sulfurtransferase activity", "id": "GO:0102867" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006777", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "id": "A0A1W2Q693", "database": "UniProtKB" } ], "name": "Mo-molybdopterin cofactor biosynthetic process", "id": "GO:0006777" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 69, "annotation": "n_glycosylation_sequon", "start_pos": 67 }, { "end_pos": 86, "annotation": "n_glycosylation_sequon", "start_pos": 84 }, { "end_pos": 153, "annotation": "n_glycosylation_sequon", "start_pos": 151 }, { "end_pos": 168, "annotation": "n_glycosylation_sequon", "start_pos": 166 }, { "end_pos": 207, "annotation": "n_glycosylation_sequon", "start_pos": 205 }, { "end_pos": 679, "annotation": "n_glycosylation_sequon", "start_pos": 677 }, { "end_pos": 733, "annotation": "n_glycosylation_sequon", "start_pos": 731 }, { "end_pos": 745, "annotation": "n_glycosylation_sequon", "start_pos": 743 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254528.1", "id": "XP_006254528.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-947581", "id": "R-RNO-947581", "database": "Reactome" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005302", "id": "IPR005302", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011037", "id": "IPR011037", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "id": "IPR015421", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "id": "IPR015422", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "id": "IPR015424", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000192", "id": "IPR000192", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005303", "id": "IPR005303", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028886", "id": "IPR028886", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03473", "id": "PF03473", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00266", "id": "PF00266", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF03476", "id": "PF03476", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/361300", "id": "361300", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308496", "id": "1308496", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A1W2Q693", "disease": [], "mass": { "monoisotopic_mass": 94600.0, "chemical_mass": 94600.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q693", "name": "Mocos; MOCOS.", "locus": { "end_pos": 16636084, "start_pos": 16590197, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015113", "id": "ENSRNOG00000015113", "database": "Ensembl Gene" } ] } } ] }