{ "uniprot_canonical_ac": "A0A1W2Q656-1", "sequence": { "header": "tr|A0A1W2Q656-1|A0A1W2Q656_RAT Isoform 1 of Delta/notch-like EGF repeat-containing OS=Rattus norvegicus OX=10116 GN=Dner PE=1 SV=1 CANONICAL=A0A1W2Q656-1", "length": 746, "sequence": "MPPRRAQAPGAPLLPVLALLPLLLGAGPQSSCLASPVPAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAVDAEPGYSCTCPAGVSGTDCQFVADPCASNPCHHGNCSSSSSSSSSSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESMAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDATALLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLTLGPNHFIGFVNDSVAKSIVALRLTLVVKASTCVPGDGHSNDIECSGKGKCATKPSEATFSCTCEDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL" }, "uniprot_id": "A0A1W2Q656_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "delta and Notch-like epidermal growth factor-related receptor" ], "uniprotkb": [ "Delta/notch-like EGF repeat-containing", "RCG23980, isoform CRA_a" ] }, "gene": { "refseq": [ "Dner" ], "uniprotkb": [ "Dner", "rCG_23980" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Delta/notch-like EGF repeat-containing; RCG23980, isoform CRA_a." }, "publication": [ { "title": "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16641100", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656/publications", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "authors": "Wang G., Shen R.F., Knepper M.A., Shen R.-F., Hoffert J.D., Pisitkun T.", "date": "2006", "pmid": "16641100" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656#A0A1W2Q656-1", "isoform_ac": "A0A1W2Q656-1", "locus": { "end_pos": 91966797, "start_pos": 92290727, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000093357", "id": "ENSRNOT00000093357", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000076139", "id": "ENSRNOP00000076139", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2Q656-1|A0A1W2Q656_RAT Isoform 1 of Delta/notch-like EGF repeat-containing OS=Rattus norvegicus OX=10116 GN=Dner PE=1 SV=1 CANONICAL=A0A1W2Q656-1", "length": 746, "sequence": "MPPRRAQAPGAPLLPVLALLPLLLGAGPQSSCLASPVPAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAVDAEPGYSCTCPAGVSGTDCQFVADPCASNPCHHGNCSSSSSSSSSSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESMAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDATALLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLTLGPNHFIGFVNDSVAKSIVALRLTLVVKASTCVPGDGHSNDIECSGKGKCATKPSEATFSCTCEDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:316573", "resource": "KEGG Pathway", "id": "rno:316573", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8NFT8-1", "protein_name": "Delta and Notch-like epidermal growth factor-related receptor.", "sequence": { "length": 737, "sequence": "MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKPLVTLIKTKDL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/26722", "id": "26722", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8JZM4-1", "protein_name": "Delta and Notch-like epidermal growth factor-related receptor; Brain EGF repeat-containing transmembrane protein.", "sequence": { "length": 737, "sequence": "MPPRRAQAPGAPLLPVLALLPLLLGAGPQSGCLASPVSAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAADAEPRYSCTCPAGVSGTYCQFVADPCASNPCHHGNCSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESTAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDANSLLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLALGPNHFIGFVNDSVAKSIVALRLTLVVKASNCVPGDSHSNDLECSGKGKCATKPSEATFSCTCQDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLINGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/26722", "id": "26722", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452337.1", "ac": "XP_017452337.1", "name": "delta and Notch-like epidermal growth factor-related receptor.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005112", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "Notch binding", "id": "GO:0005112" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "early endosome", "id": "GO:0005769" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007220", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "Notch receptor processing", "id": "GO:0007220" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "central nervous system development", "id": "GO:0007417" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "skeletal muscle fiber development", "id": "GO:0048741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010001", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "id": "A0A1W2Q656", "database": "UniProtKB" } ], "name": "glial cell differentiation", "id": "GO:0010001" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 109, "annotation": "n_glycosylation_sequon", "start_pos": 107 }, { "end_pos": 215, "annotation": "n_glycosylation_sequon", "start_pos": 213 }, { "end_pos": 219, "annotation": "n_glycosylation_sequon", "start_pos": 217 }, { "end_pos": 234, "annotation": "n_glycosylation_sequon", "start_pos": 232 }, { "end_pos": 297, "annotation": "n_glycosylation_sequon", "start_pos": 295 }, { "end_pos": 386, "annotation": "n_glycosylation_sequon", "start_pos": 384 }, { "end_pos": 453, "annotation": "n_glycosylation_sequon", "start_pos": 451 }, { "end_pos": 560, "annotation": "n_glycosylation_sequon", "start_pos": 558 }, { "end_pos": 575, "annotation": "n_glycosylation_sequon", "start_pos": 573 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452337.1", "id": "XP_017452337.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:316573", "id": "rno:316573", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "id": "IPR000742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "id": "IPR013032", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "id": "IPR000152", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "id": "IPR001881", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "id": "IPR009030", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "id": "IPR018097", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00008", "id": "PF00008", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12661", "id": "PF12661", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/316573", "id": "316573", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359385", "id": "1359385", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A1W2Q656", "disease": [], "mass": { "monoisotopic_mass": 79427.0, "chemical_mass": 79427.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A1W2Q656", "name": "Dner; rCG_23980.", "locus": { "end_pos": 91965866, "start_pos": 92291220, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000016640", "id": "ENSRNOG00000016640", "database": "Ensembl Gene" } ] } } ] }