{
    "uniprot_canonical_ac": "A0A1W2PR19-1", 
    "sequence": {
        "header": "sp|A0A1W2PR19-1|GSTT4_HUMAN Isoform 1 of Glutathione S-transferase theta-4  OS=Homo sapiens OX=9606 GN=GSTT4 PE=3 SV=1 CANONICAL=A0A1W2PR19-1", 
        "length": 241, 
        "sequence": "MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGHHHSKGYIDINPLRKLPSLKDGKFILSESAAILYYLCRKYSAPSHWCPPDPHARARVDEFVAWQHTAFQLPMKKIVWLKLLIPKITGEEVSAEKMEHAVEEVKNSLQLFEEYFLQDKMFITGNQISLADLVAVVEMMQPMAANYNVFLNSSKLAEWRMQVELNIGSGLFREAHDRLMQLADWDFSTLDSMVKENISELLKKSR"
    }, 
    "uniprot_id": "GSTT4_HUMAN", 
    "enzyme_annotation": [
        {
            "ec": "2.5.1.18", 
            "activity": "RX + glutathione = HX + R-S-glutathione."
        }, 
        {
            "ec": "2.5.1.18", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Glutathione S-transferase theta-4", 
                "2.5.1.18", 
                "Glutathione S-transferase theta pseudogene 1", 
                "GST class-theta-4"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "GSTT4", 
                "GSTTP1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR19", 
                    "id": "A0A1W2PR19", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Glutathione S-transferase theta-4; 2.5.1.18; Glutathione S-transferase theta pseudogene 1; GST class-theta-4."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR19#A0A1W2PR19-1", 
            "isoform_ac": "A0A1W2PR19-1", 
            "locus": {
                "end_pos": 23998545, 
                "start_pos": 24005356, 
                "chromosome": "22", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000621179", 
                        "id": "ENST00000621179", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000492273", 
                        "id": "ENSP00000492273", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A1W2PR19-1|GSTT4_HUMAN Isoform 1 of Glutathione S-transferase theta-4  OS=Homo sapiens OX=9606 GN=GSTT4 PE=3 SV=1 CANONICAL=A0A1W2PR19-1", 
                "length": 241, 
                "sequence": "MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGHHHSKGYIDINPLRKLPSLKDGKFILSESAAILYYLCRKYSAPSHWCPPDPHARARVDEFVAWQHTAFQLPMKKIVWLKLLIPKITGEEVSAEKMEHAVEEVKNSLQLFEEYFLQDKMFITGNQISLADLVAVVEMMQPMAANYNVFLNSSKLAEWRMQVELNIGSGLFREAHDRLMQLADWDFSTLDSMVKENISELLKKSR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR19#A0A1W2PP95-1", 
            "isoform_ac": "A0A1W2PP95-1", 
            "locus": {
                "end_pos": 24004309, 
                "start_pos": 24005356, 
                "chromosome": "22", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000617532", 
                        "id": "ENST00000617532", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000491048", 
                        "id": "ENSP00000491048", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A1W2PP95-1|GSTT4_HUMAN Computationally mapped isoform of Glutathione S-transferase theta-4  OS=Homo sapiens OX=9606 GN=GSTT4 PE=3 SV=1 CANONICAL=A0A1W2PR19-1", 
                "length": 42, 
                "sequence": "MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGSLLR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR19#A0A1W2PQM5-1", 
            "isoform_ac": "A0A1W2PQM5-1", 
            "locus": {
                "end_pos": 23998552, 
                "start_pos": 24005066, 
                "chromosome": "22", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000630463", 
                        "id": "ENST00000630463", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000491805", 
                        "id": "ENSP00000491805", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A1W2PQM5-1|GSTT4_HUMAN Computationally mapped isoform of Glutathione S-transferase theta-4  OS=Homo sapiens OX=9606 GN=GSTT4 PE=3 SV=1 CANONICAL=A0A1W2PR19-1", 
                "length": 241, 
                "sequence": "MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGHHHSKEYIDINPLRKLPSLKDGKFILSESAAILYYLCRKYSAPSHWCPPDLHARARVDEFVAWQHTAFQLPMKKIVWLKLLIPKITGEEVSAEKMEHAVEEVKNSLQLFEEYFLQDKMFITGNQISLADLVAVVEMMQPMAANYNVFLNSSKLAEWRMQVELNIGSGLFREAHDRLMQLADWDFSTLDSMVKENISELLKKSR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR19#A0A1W2PRF8-1", 
            "isoform_ac": "A0A1W2PRF8-1", 
            "locus": {
                "end_pos": 24000248, 
                "start_pos": 24005356, 
                "chromosome": "22", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000611600", 
                        "id": "ENST00000611600", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000492640", 
                        "id": "ENSP00000492640", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A1W2PRF8-1|GSTT4_HUMAN Computationally mapped isoform of Glutathione S-transferase theta-4  OS=Homo sapiens OX=9606 GN=GSTT4 PE=3 SV=1 CANONICAL=A0A1W2PR19-1", 
                "length": 68, 
                "sequence": "MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGHHHSKGYIDINPLRKLPSLKDGKFILSESC"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR19#function", 
            "annotation": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR19#function", 
                    "id": "A0A1W2PR19", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PR19", 
                                "id": "A0A1W2PR19", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glutathione transferase activity", 
                        "id": "GO:0004364"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PR19", 
                                "id": "A0A1W2PR19", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 189, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 187
        }, 
        {
            "end_pos": 234, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 232
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26930", 
            "id": "26930", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A1W2PR19", 
            "id": "NX_A0A1W2PR19", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=GSTT4", 
            "id": "GSTT4", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03183", 
            "id": "cd03183", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004045", 
            "id": "IPR004045", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010987", 
            "id": "IPR010987", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", 
            "id": "IPR036249", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004046", 
            "id": "IPR004046", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", 
            "id": "IPR036282", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040077", 
            "id": "IPR040077", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", 
            "id": "IPR040079", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00043", 
            "id": "PF00043", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13417", 
            "id": "PF13417", 
            "database": "Pfam"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A1W2PR19", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 27942.0, 
        "chemical_mass": 27942.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR19", 
            "name": "GSTT4; GSTTP1.", 
            "locus": {
                "end_pos": 23998401, 
                "start_pos": 24005453, 
                "chromosome": "22", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000276950", 
                        "id": "ENSG00000276950", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}