{ "uniprot_canonical_ac": "A0A1C7CYV8-1", "sequence": { "header": "tr|A0A1C7CYV8-1|A0A1C7CYV8_HUMAN Isoform 1 of POU domain protein OS=Homo sapiens OX=9606 GN=POU6F1 PE=1 SV=1 CANONICAL=A0A1C7CYV8-1", "length": 611, "sequence": "MDPGAGSETSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESKGLEGVAAEGSQSGDPAEASQAAGEAGPDNLGSSAEATVKSPPGIPPSPATAIATFSQAPSQPQASQTLTPLAVQAAPQVLTQENLATVLTGVMVPAGAVTQPLLIPISIAGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGVFKPPLAGLQAAAVLNTALPAPVQAAAPVQASSTAQPRPPAQPQTLFQTQPLLQTTPAILPQPTAATAAAPTPKPVDTPPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITSAIPSMPGISSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP" }, "uniprot_id": "A0A1C7CYV8_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "POU domain, class 6, transcription factor 1 isoform 2", "POU domain, class 6, transcription factor 1; brain-5; mPOU homeobox protein; brain-specific homeobox/POU domain protein 5" ], "uniprotkb": [ "POU domain protein" ] }, "gene": { "refseq": [ "POU6F1", "BRN5", "MPOU", "TCFB1" ], "uniprotkb": [ "POU6F1", "BRN5", "MPOU", "TCFB1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8", "id": "A0A1C7CYV8", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "POU domain protein." }, "publication": [ { "title": "Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20134265", "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ], "authors": "Suzuki N, Yoshioka N, Uekawa A, Matsumura N, Tozawa A, Koike J, Konishi I, Kiguchi K, Ishizuka B", "date": "2010", "pmid": "20134265" }, { "title": "POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19874398", "journal": "Human cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ], "authors": "Yoshioka N, Suzuki N, Uekawa A, Kiguchi K, Ishizuka B", "date": "2009", "pmid": "19874398" }, { "title": "Structure of human Brn-5 transcription factor in complex with CRH gene promoter.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19450691", "journal": "Journal of structural biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ], "authors": "Pereira JH, Kim SH", "date": "2009", "pmid": "19450691" }, { "title": "Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18323601", "journal": "Acta crystallographica. Section F, Structural biology and crystallization communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ], "authors": "Pereira JH, Ha SC, Kim SH", "date": "2008", "pmid": "18323601" }, { "title": "Identification of novel DNA binding sites recognized by the transcription factor mPOU (POU6F1).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8645295", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ], "authors": "Wey E, Schafer BW", "date": "1996", "pmid": "8645295" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8#A0A1C7CYY7-1", "isoform_ac": "A0A1C7CYY7-1", "locus": { "end_pos": 51190250, "start_pos": 51206836, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000550824", "id": "ENST00000550824", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000448389", "id": "ENSP00000448389", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1C7CYY7-1|A0A1C7CYV8_HUMAN Computationally mapped isoform of POU domain protein OS=Homo sapiens OX=9606 GN=POU6F1 PE=1 SV=1 CANONICAL=A0A1C7CYV8-1", "length": 577, "sequence": "MDPGAGSETSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESKGLEGVAAEGSQSGDPAEASQAAGEAGPDNLGSSAEATVTPGDPSEPCHCHCHLQPSPKPASGIADPDATGCTSCPPGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGVFKPPLAGLQAAAVLNTALPAPVQAAAPVQASSTAQPRPPAQPQTLFQTQPLLQTTPAILPQPTAATAAAPTPKPVDTPPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITSAIPSMPGISSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP" } }, { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8#A0A1B0GU61-1", "isoform_ac": "A0A1B0GU61-1", "locus": { "end_pos": 51197783, "start_pos": 51206836, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000636728", "id": "ENST00000636728", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489978", "id": "ENSP00000489978", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1B0GU61-1|A0A1C7CYV8_HUMAN Computationally mapped isoform of POU domain protein OS=Homo sapiens OX=9606 GN=POU6F1 PE=1 SV=1 CANONICAL=A0A1C7CYV8-1", "length": 248, "sequence": "MDPGAGSETSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESKGLEGVAAEGSQSGDPAEASQAAGEAGPDNLGSSAEATVKSPPGIPPSPATAIATFSQAPSQPQASQTLTPLAVQAAPQYCRSSGWSAGAGRVDNSYSNCGCPPRTDRCFSYGGSVQATFSRSPSSCCAEHRSSGTGTSCRTSTGLLDGPTPATSPAPDAVPDPAAAADHTCHPPAAHCCHRCCPYPQASGHPPTDHRPACRLRI" } }, { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8#A0A1B0GVK9-1", "isoform_ac": "A0A1B0GVK9-1", "locus": { "end_pos": 51192390, "start_pos": 51198023, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000552305", "id": "ENST00000552305", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000490559", "id": "ENSP00000490559", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1B0GVK9-1|A0A1C7CYV8_HUMAN Computationally mapped isoform of POU domain protein OS=Homo sapiens OX=9606 GN=POU6F1 PE=1 SV=1 CANONICAL=A0A1C7CYV8-1", "length": 180, "sequence": "XAAVLNTALPAPVQAAAPVQASSTAQPRPPAQPQTLFQTQPLLQTTPAILPQPTAATAAAPTPKPVDTPPQITVQPAGFAFSPGIVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPS" } }, { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8#A0A1C7CYV8-1", "isoform_ac": "A0A1C7CYV8-1", "locus": { "end_pos": 51190250, "start_pos": 51206836, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000333640", "id": "ENST00000333640", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000330190", "id": "ENSP00000330190", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1C7CYV8-1|A0A1C7CYV8_HUMAN Isoform 1 of POU domain protein OS=Homo sapiens OX=9606 GN=POU6F1 PE=1 SV=1 CANONICAL=A0A1C7CYV8-1", "length": 611, "sequence": "MDPGAGSETSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESKGLEGVAAEGSQSGDPAEASQAAGEAGPDNLGSSAEATVKSPPGIPPSPATAIATFSQAPSQPQASQTLTPLAVQAAPQVLTQENLATVLTGVMVPAGAVTQPLLIPISIAGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGVFKPPLAGLQAAAVLNTALPAPVQAAAPVQASSTAQPRPPAQPQTLFQTQPLLQTTPAILPQPTAATAAAPTPKPVDTPPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITSAIPSMPGISSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:5463", "resource": "KEGG Pathway", "id": "hsa:5463", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "annotation": "POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "annotation": "Is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "annotation": "The crystal structure of human Brn-5 transcription factor in complex with corticotropin-releasing hormone gene promoter reveals an unexpected recognition mode of the protein to its cognate DNA", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "annotation": "Crystallization and preliminary X-ray analysis", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q07916-1", "protein_name": "POU domain, class 6, transcription factor 1; Octamer-binding transcription factor EMB; Transcription regulatory protein MCP-1.", "sequence": { "length": 301, "sequence": "MPGISSQILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/7703", "id": "7703", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "P56223-1", "protein_name": "POU domain, class 6, transcription factor 1; POU domain protein 5; Brain-5; Brn-5.", "sequence": { "length": 301, "sequence": "MPGISSPILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPSTPESPAKSEVQPIQPTQAVPPPAVILTSPAPALKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/7703", "id": "7703", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "ac": "NP_001317351.1", "name": "POU domain, class 6, transcription factor 1 isoform 2; POU domain, class 6, transcription factor 1; brain-5; mPOU homeobox protein; brain-specific homeobox/POU domain protein 5.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8", "id": "A0A1C7CYV8", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8", "id": "A0A1C7CYV8", "database": "UniProtKB" } ], "name": "RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:0000977" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8", "id": "A0A1C7CYV8", "database": "UniProtKB" } ], "name": "actin cytoskeleton", "id": "GO:0015629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8", "id": "A0A1C7CYV8", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" } ], "total": 2, "name": "Cellular Component" } ] }, "site_annotation": [ { "end_pos": 603, "annotation": "n_glycosylation_sequon", "start_pos": 601 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317351.1", "id": "NP_001317351.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:5463", "id": "hsa:5463", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/HCHLQPS/", "id": "HCHLQPS", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "id": "cd00086", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "id": "IPR001356", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010982", "id": "IPR010982", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013847", "id": "IPR013847", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000327", "id": "IPR000327", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00046", "id": "PF00046", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00157", "id": "PF00157", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/5463", "id": "5463", "database": "GeneID" } ], "expression_disease": [], "uniprot_ac": "A0A1C7CYV8", "disease": [], "mass": { "monoisotopic_mass": 63068.0, "chemical_mass": 63068.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A1C7CYV8", "name": "POU6F1; BRN5; MPOU; TCFB1.", "locus": { "end_pos": 51186936, "start_pos": 51217708, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000184271", "id": "ENSG00000184271", "database": "Ensembl Gene" } ] } } ] }